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Clinical efficacy of lower dose flutamide 125 mg/day in the treatment of hirsutism

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Abstract

Thirty-four patients with moderate-severe hirsutism were enrolled in this study. The patients received 125 mg/day flutamide for a period of 6 months. Hirsutism score and hormone parameters including FSH, LH, T, free T, androste-nedione (A), DHEAS, PRL and sex hormone-binding globulin (SHBG) levels were evaluated in all patients before treatment and repeated at every three-monthly intervals. Hirsutism greatly improved during flutamide therapy, and the hirsutism score significantly decreased at month 3 and 6 from a mean (±SD) of 17.19±4.55 to 10.75±3.84 (p<0.001) and 17.19±4.55 to 5.91±2.53 (p<0.001), respectively. A significant reduction in hirsutism score (mean%±SD) as compared to baseline was observed at 3 months (37.78±13.30, p<0.001) and at 6 months (65.47±13.49, p<0.001). No significant changes in the levels of hormone and no serious side effects were observed in the patients. The lower dose flutamide, 125 mg/day, is a safe and cost-effective drug in the treatment of hirsutism. Lower dose flutamide may be used in place of high dose flutamide, 250 to 750 mg/day.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Erciyes University, Faculty of Medicine, 38039, Kayseri, Turkey

    I. I. Müderris M.D.

  2. Department of Endocrinology, Erciyes University, Faculty of Medicine, Kayseri, Turkey

    F. Bayram

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  1. I. I. Müderris M.D.
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  2. F. Bayram
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Müderris, I.I., Bayram, F. Clinical efficacy of lower dose flutamide 125 mg/day in the treatment of hirsutism. J Endocrinol Invest 22, 165–168 (1999). https://doi.org/10.1007/BF03343536

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