Venlafaxine versus fluoxetine in the treatment of atypical anorectic outpatients: A preliminary study

  • V. Ricca
  • E. Mannucci
  • A. Paionni
  • M. Di Bernardo
  • M. Cellini
  • P. L. Cabras
  • C. M. Rotella
Brief Report


The efficacy of venlafaxine and fluoxetine in the treatment of atypical anorexia nervosa (AN) was compared in a controlled trial. A consecutive series of 24 atypical anorectic females was assigned to either venlafaxine (75 mg/day) or fluoxetine (40 mg/day) plus cognitive-behavioural therapy (CBT). Eating Disorder Examination (EDE12.0D), Beck Depression Inventory (BDI) and State and Trait Anxiety Inventory (STAI) scores were compared before and after 6 months of treatment. Venlafaxine and fluoxetine determined an increase of body mass index (BMI) and a significant reduction of EDE12.0D and BDI scores venlafaxine alone reduced STAI scores. It would seem that venlafaxine is as effective as fluoxetine when combined with CBT in the treatment of atypical AN.

Key words

Venlafaxine fluoxetine atypical anorexia nervosa cognitive-behavioural therapy psychiatric comorbidity 


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Copyright information

© Editrice Kurtis 1999

Authors and Affiliations

  • V. Ricca
    • 1
  • E. Mannucci
    • 2
  • A. Paionni
    • 1
  • M. Di Bernardo
    • 1
  • M. Cellini
    • 1
  • P. L. Cabras
    • 1
  • C. M. Rotella
    • 2
  1. 1.Psychiatric Unit, Department of Neurologic and Psychiatric SciencesUniversity of FirenzeItaly
  2. 2.Section of Metabolic Diseases and Diabetology, Unit of Endocrinology Department of Clinical PathophysiologyUniversity of FirenzeFirenzeItaly

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