Abstract
The aqueous solubility of the pesticide 2,4-D was improved by inclusion complexation with α-CD. The formation of such inclusion compounds was studied via the phase-solubility diagram (solution state) and by DSC and HSM (solid state). 2,4-D presented a typical Bs Higuchi solubility curve, coprecipitating a 1:2 pesticide-α-CD complex. In order to obtain solid complexes, three processing methods were checked: kneading, coprecipitation and spray-drying. DSC and HSM showed that only the last two of these yielded true inclusion compounds. Chemical analysis also revealed that the stoichiometry of such solid complexes corresponds to a 2,4-D-α-CD ratio of 1:2.
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Pérez-Martínez, J.I., Arias, M.J., Ginés, J.M. et al. 2,4-D-α-Cyclodextrin Complexes. Journal of Thermal Analysis 51, 965–972 (1998). https://doi.org/10.1007/BF03341476
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DOI: https://doi.org/10.1007/BF03341476