Abstract
This study focused in the treatment of two major Prader-Willi symptoms: hyper phagia and self-injurious behavior (SIB). Four patients participated in a four-year study with monthly follow-ups. Patients lived in a behaviorally structured environment, and were treated with selective serotonin reuptake blockers and phenothiazines. Psychopharmacological inter vention improved SIB symptoms, but was ineffective to control appetite satiation.
Similar content being viewed by others
References
Pettigrew A.L., Gollin S.M., Greenberg F., Riccardi V.M., Ledbetter D.H., Duplication of proximal 15q as a cause of Prader-Willi syndrome. Am. J. Med. Genet., 28, 791–802, 1987.
Ledbetter H., Greenberg F., Holm V.A., Cassidy S.B., Conference report: second annual Prader-Willi syndrome scientific conference. Am. J. Med. Genet., 28, 779–790, 1987.
Holm V.A., The diagnosis of Prader-Willi syndrome. In: Holm V.A., Sulzbacher S.J., Pipes P. (Eds.), Prader Willi Syndrome. Baltimore, University Park Press, 1981, pp. 27–44.
Yaryura-Tobias J.A., Neziroglu F., Obsessive-compulsive disorder spectrum: Pathogenesis, diagnosis, and treatment. Washington, D.C., American Psychiatric Press, Inc., 1997.
Curfs L.M.G., Verhulst F.C., Fryns J.P., Behavioral and emotional problems in youngsters with Prader-Willi syndrome. Genet. Couns., 2, 33–41, 1990.
Gabel S., Tarter R.E., Gavaler J., Golden W.L., Hegedus A.M., Maier B., Neuropsychological capacity of Prader-Willi children: General and specific aspects of impairment. Applied Research in Mental Retardation, 7, 459–466, 1986.
Bartolucci G., Younger J., Tentative classification of neuropsychiatrie disturbances in Prader-Willi syndrome. J. Intellect. Disabil. Res., 38, 621–629, 1994.
Benjamin E., Buot-Smith T., Naltrexone and fluoxetine in Prader-Willi syndrome. J. Am. Acad. Child Adolesc. Psychiatry, 32, 870–873, 1993.
Borghgraef M., Fryns J.P., Van Den Berghe H., Psychological profile and behavioral characteristics in 12 patients with Prader-Willi syndrome. Genet. Couns., 38, 141–150, 1990.
Eichelmann B., Catecholamines and aggressive behavior. In: Usdin E. (Ed.), Neuroregulators and Psychiatric disorders. New York, Oxford, 1977.
Insel T.R., Zohar J., Benkelfat C: Serotonin in obsessions, compulsions, and the control of aggressive impulses. In: Whitaker-Azmita P.M., Peroutka SJ. (Eds.), The neuropharmacology of serotonin, New York, New York Academy of Sciences, 1990, pp. 574–586.
Jimersen D.C., Lesem M.D., Hegg A.P: Serotonin in human eating disorders. In: Whitaker-Azmita P.M., Peroutka S.J., (Eds.), The neuropharmacology of serotonin, New York, New York Academy of Sciences, 1990, pp. 532–544.
Stein DJ., Keatings J., Zar H., Hollander E., A survey of the phenomenology and pharmacotherapy of compulsive and compulsive-aggressive symptoms in Prader-Willi syndrome. J. Neuropsychiatry Clin. Neurosci., 6, 23–29, 1994.
Hellings J.S., Warnock J.K.: Self-injurious behavior and serotonin Prader-Willi syndrome. Psychopharmacol. Bull., 30, 245–250, 1994.
Tu J.B., Hartridge C., Izawa J., Psycho-pharmacogenetic aspects of Prader Willi syndrome. J. Acad. Child Adolesc. Psychiatry, 31, 1137–1140, 1992.
Ballard C.G., Mohan R.N., McGibben L., Kurian M., The phenomena of “bingeing”. Ir. J. Psychol. Med., 9, 61–62, 1992.
Yaryura-Tobias JA., Neziroglu F., Kaplan S., Self-mutilation, anorexia, and dysmenorrhea in obsessive compulsive disorder. Int. J. Eating Disord., 10, 47–57, 1995.
Yaryura-Tobias J.A., Gilles de la Tourette syndrome: Interactions with other neuropsychiatrie disorders. Acta Psychiatr. Scand. 59, 9–16, 1979.
Aman M.G., White A.J: Thioridazine dose effects with reference to stereotypic behavior in mentally retarded residents. J. Autism Dev. Disord., 18, 3, 1988.
Singh N.N., Millichamp C.J., Pharmacological treatment of self-injurious behavior in mentally retarded persons. J. Autism Dev. Disord., 15, 257–267, 1985.
Singh N.N., Winton A.S., Behavioral monitoring of pharmacological interventions for self injury. Applied Research in Mental Retardation, 5, 161–170, 1984.
Bodfish J.W., Madison J.T., Diagnosis and fluoxetine treatment of compulsive behavior disorder of adults with mental retardation. Am. J. Ment. Retard., 98, 360–367, 1993.
Elftheriou B.E., Psychopharmacogenetics. New York, Plenum Press, 1975, pp 1–10.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yaryura-Tobias, J.A., Grunes, M.S., Bayles, M.E. et al. Hyperphagia and self-mutilation in Prader-Willi syndrome: Psychopharmacological issues. Eat Weight Disord 3, 163–167 (1998). https://doi.org/10.1007/BF03340005
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03340005