Aging Clinical and Experimental Research

, Volume 8, Issue 6, pp 370–378 | Cite as

Effects of energy imbalance on energy expenditure and respiratory quotient in young and older men: A summary of data from two metabolic studies

  • E. Saltzman
  • S. B. Roberts
Original Article

Abstract

The roles of energy expenditure and substrate oxidation in energy regulation, and the effects of factors such as aging on these parameters, remain uncertain. A re-analysis of data from two studies involving overfeeding or underfeeding in young men (22.7±0.6 [SEM] years) and older men (68.0±1.50 years) was conducted to further evaluate the adaptive capacity of energy expenditure and respiratory quotient to an increase or a decrease in energy intake. Changes in total energy expenditure (TEE) and resting energy expenditure (REE) and respiratory quotient (RQ) in response to energy imbalance were compared between subjects undergoing overfeeding by 4.1MJ/day for 21 days, or underfeeding by 3.2 MJ/day for 21 days. Comparing responses to overfeeding or underfeeding, there was a significant TEE response to energy imbalance averaging 1.39 MJ/day and equivalent to 19% of the alteration in energy intake (p<0.05). There was also a significant REE response to energy imbalance averaging 0.45 MJ/day (p<0.001), and a significant RQ response in both fasting and fed states (p<0.01). There was no significant difference between young and older men in their TEE, energy deposition or RQ responses to energy imbalance, but older men did have significantly diminished REE response to energy imbalance (p<0.05) and a significantly delayed thermic response to a standard meal (p<0.05). These data indicate that energy expenditure plays a significant role in attenuating the effects of alterations in energy intake on body energy stores and that, based on some measures of energy expenditure, aging is associated with a reduction in the adaptive capacity of energy expenditure to participate in energy regulation.

Key words

Aging carbohydrate energy metabolism fat 

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References

  1. 1.
    Saltzman E., Roberts S.B.: The role of energy expenditure in energy regulation: findings from a decade of research. Nutr. Rev. 53: 209–220, 1995.PubMedCrossRefGoogle Scholar
  2. 2.
    Schoeller D.A.: Measurement of energy expenditure in freeliving humans using doubly labeled water. J. Nutr. 118: 1278–1289, 1988.PubMedGoogle Scholar
  3. 3.
    Roberts S.B.: Use of the doubly labeled water method for measurement of energy expenditure, total body water, water intake, and metabolizable energy intake in humans and small animals. Can. J. Physiol. Pharm. 67: 1191–1198, 1989.Google Scholar
  4. 4.
    Roberts S.B., Young V.R., Fuss P., Fiatarone M.A., Richard B., Rasmussen H., Wagner D., Joseph L., Holehouse E., Evans W.J.: Energy expenditure and subsequent nutrient intakes in overfed young men. Am. J. Physiol. 259: R461–R469, 1990.PubMedGoogle Scholar
  5. 5.
    Diaz E.O., Prentice A.M., Goldberg G.R., Murgatroyd P.R., Coward W.A.: Metabolic response to experimental overfeeding in lean and overweight healthy volunteers. Am. J. Clin. Nutr. 56: 641–655, 1992.PubMedGoogle Scholar
  6. 6.
    Heyman M., Young V.R., Fuss P., Tsay R., Joseph L., Roberts S.B.: Underfeeding and body weight regulation in normal weight young men. Am. J. Physiol. 263: R250–R257, 1992.PubMedGoogle Scholar
  7. 7.
    Klein S., Goran M.: Energy metabolism in response to overfeeding in young adult men. Metabolism 42: 1201–1205, 1993.PubMedCrossRefGoogle Scholar
  8. 8.
    Goran M.I., Calles-Escandon J., Poehlman E.T., O’Connell M., Danforth E.: Effects of increased energy intake and/or physical activity on energy expenditure in young healthy men. J. Appl. Physiol. 77: 366–372, 1994.PubMedGoogle Scholar
  9. 9.
    Racette S.B., Schoeller D.A., Kushner R.F., Neil K.M., Herling-Iaffaldano K.: Effects of aerobic exercise and dietary carbohydrate on energy expenditure and body composition during weight reduction in obese women. Am. J. Clin. Nutr. 61: 486–494, 1995.PubMedGoogle Scholar
  10. 10.
    Roberts S.B., Fuss P., Dallal G.E., Atkinson A., Evans W.J., Joseph L., Fiatarone M.A., Greenberg A.S., Young V.R.: Effects of age on energy expenditure and substrate oxidation during experimental overfeeding in healthy men. J. Gerontol., 1996 (in press).Google Scholar
  11. 11.
    Roberts S.B., Fuss P., Heyman M.B., Dallal G.E., Young V.R.: Effects of age on energy expenditure and substrate oxidation during experimental underfeeding in healthy men. J. Gerontol., 1996 (in press).Google Scholar
  12. 12.
    Roberts S.B., Heyman M.B., Evans W.J., Fuss P., Tsay R., Young V.R.: Dietary energy requirements of young adult men, determined by using the doubly labeled water method. Am. J. Clin. Nutr. 54: 499–505, 1991.PubMedGoogle Scholar
  13. 13.
    Roberts S.B., Young V.R., Fuss P., Heyman M.B., Fiatarone M.A., Dallal G.E., Evans W.J.: What are the dietary energy needs of elderly adults? Int. J. Obesity 16: 969–976, 1992.Google Scholar
  14. 14.
    Roberts S.B., Fuss P., Heyman M.B., Evans W.J., Tsay R., Rasmussen H., Fiatarone M., Cortiella J., Dallal G.E., Young V.R.: Control of food intake in older men. JAMA 272: 1601–1606, 1994.PubMedCrossRefGoogle Scholar
  15. 15.
    Roberts S.B., Fuss P., Heyman M.B., Young V.R.: Influence of age on energy requirements. Am. J. Clin. Nutr. 62 (Suppl.): 1053S–1058S, 1995.PubMedGoogle Scholar
  16. 16.
    Committee on Diet and Health, Food and Nutrition Board, Commission on Life, National Research Council.: Diet and health: Implications for reducing chronic disease. National Academy Press, Washington, DC, 1989.Google Scholar
  17. 17.
    Weir J.B.de V.: New method for calculating metabolic rate with special reference to protein metabolism. J. Physiol. 109: 1–9, 1949.PubMedGoogle Scholar
  18. 18.
    Dallal G.E., Roberts S.B.: DLW: a computer program for the calculation of total energy expenditure in doubly labeled water (2H2 18O) studies. Comp. Biomed. Res. 24: 143–151, 1991.CrossRefGoogle Scholar
  19. 19.
    Halliday D., Miller A.G.: Precise measurement of total body water using trace quantities of deuterium oxide. Biomed. Mass. Spectrom. 4: 82–87, 1977.PubMedCrossRefGoogle Scholar
  20. 20.
    Racette S.B., Schoeller D.A., Luke A.H., Shay K., Hnilicka J., Kushner R.F.: Relative dilution spaces of 2H and 180 labeled water in humans. Am. J. Physiol. 267: E585–E590, 1994.PubMedGoogle Scholar
  21. 21.
    Schoeller D.A., Ravussin E., Schutz Y., Acheson K.J., Baertschi P., Jequier E.: Energy expenditure by doubly labeled water: validation in humans and proposed calculation. Am. J. Physiol. 250: R823–R830, 1986.PubMedGoogle Scholar
  22. 22.
    Pace N., Rathburn E.N.: Studies on body composition. III. The body water and chemically combined nitrogen content in relation to fat content. J. Biol. Chem. 158: 685–691, 1945.Google Scholar
  23. 23.
    Garrow J.S.: Energy balance and obesity in man. North Holland Publishing Co., Amsterdam, 1974.Google Scholar
  24. 24.
    Gulick, A.: A study of weight regulation in the adult human body during over-nutrition. Am. J. Physiol. 60: 371–395, 1922.Google Scholar
  25. 25.
    Ashworth N., Creedy S., Hunt J.N., Mahon S., Newland P.: Effect of nightly food supplements on food intake in man. Lancet II: 685–687, 1962.CrossRefGoogle Scholar
  26. 26.
    Miller D.S., Mumford P.: Gluttony 1.: An experimental study of overeating low- or high-protein diets. Am. J. Clin. Nutr. 20: 1212–1222, 1967.PubMedGoogle Scholar
  27. 27.
    Welle S., Matthews D.E., Campbell R.G., Nair K.S.: Stimulation of protein turnover by carbohydrate overfeeding in men. Am. J. Physiol. 257: E413–E417, 1989.PubMedGoogle Scholar
  28. 28.
    Tzankoff S.P., Norris A.H.: Longitudinal changes in basal metabolic rate in man. J. Appl. Physiol. 33: 536–539, 1978.Google Scholar
  29. 29.
    Poehlman E.T., McAuliffe T.L., Van Houten D.R., Danforth E.J.: Influence of age and endurance training on metabolic rate and hormones in healthy men. Am. J. Physiol. 259: E66–E72, 1990.PubMedGoogle Scholar
  30. 30.
    Vaughan L., Zurlo F., Ravussin E.: Aging and energy expenditure. Am. J. Clin. Nutr. 53: 821–825, 1991.PubMedGoogle Scholar
  31. 31.
    Goran M.I., Poehlman E.T.: Total energy expenditure and energy requirements in healthy elderly persons. Metabolism 41: 744–753, 1992.PubMedCrossRefGoogle Scholar
  32. 32.
    Bonadonna R.C., Groop L.C., Simonson D.C., DeFronzo R.A.: Free fatty acid and glucose metabolism in human aging: evidence for operation of the Randle cycle. Am. J. Physiol. 266: E501–E509, 1994.PubMedGoogle Scholar
  33. 33.
    Calles-Escandon J., Arciero P.J., Gardner A.W., Bauman C., Poehlman E.T: Basal fat oxidation decreases with aging in women. J. Appl. Physiol. 78: 266–271, 1995.PubMedGoogle Scholar
  34. 34.
    Kohrt W.M., Spina R.J., Ehsani A.A., Cryer P.E., Holloszy J.O.: Effects of age, adiposity, and fitness level on plasma catecholamine responses to standing and exercise. J. Appl. Physiol. 75: 1828–1835, 1993.PubMedGoogle Scholar

Copyright information

© Springer Internal Publishing Switzerland 1996

Authors and Affiliations

  • E. Saltzman
    • 1
  • S. B. Roberts
    • 1
  1. 1.Energy Metabolism Laboratory, The Jean Mayer U.S.D.A. Human Nutrition Research Center on AgingTufts UniversityBostonUSA

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