Skip to main content
SpringerLink
Log in

Evaluation of hormone replacement therapy which may have an adrenomedullin-mediated protective effect on cardiovascular disorders

  • Original Articles
  • Published:
Aging Clinical and Experimental Research Aims and scope Submit manuscript

Abstract

Background and aims: This study aimed to determine whether there is an adrenomedullin (AM)-mediated protective effect of postmenopausal estrogen/progestin therapy (HRT) against cardiovascular disorders. Methods: A total of 22 postmenopausal women without hysterectomy undergoing postmenopausal symptoms (aged 43–52) were treated with conjugated equine estrogen (0.625 mg/die) plus medroxyprogesterone acetate (2.5 mg/die) for six months. The flow velocity of the right middle cerebral artery [measured as resistance index (RI) and pulsatility index (PI)], plasma levels of adrenomedullin and endothelin-1 (ET-1), mean baseline ratio of AM to ET-1, and lipid profiles were assessed before and after HRT. Results: A statistically significant difference was found for triglycerides, total cholesterol, AM/ET-1 ratio and right middle cerebral artery PI (p<0.05), without any significant differences in HDL, LDL, AM, ET-1, systolic blood pressure, diastolic blood pressure, a right middle cerebral artery RI (p>0.05) between pre- and post- HRT. Conclusions: Adrenomedullin may be added to other vasoactive peptides as a new potential candidate for HRT-mediated vascular protection. The ratio of AM/ET-1 vs AM or ET-1 alone may be a useful biological marker of this protection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kitamura K, Kangawa K, Kuwasako M, et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993; 194: 720–5.

    Article  PubMed  CAS  Google Scholar 

  2. Sugo S, Minamino N, Kangawa K, et al. Endothelial cells activity synthesize and secrete adrenomedullin. Biochem Biophys Res Commun 1994; 201: 1160–6.

    Article  PubMed  CAS  Google Scholar 

  3. Nussdorfer GG. Proadrenomedullin-derived peptides in the paracrine control of the hypothalamo-pituitary adrenal axis. Int Rev Cytol 2001; 206: 249–84.

    Article  PubMed  CAS  Google Scholar 

  4. Samson VK. Adrenomedullin and the control of fluid and electrolyte homeostasis. Ann Rev Phsiol 1999; 61: 363–89.

    Article  CAS  Google Scholar 

  5. Eto T. A review of the biological properties and clinical implications of adrenomedullin and proadrenomedullin n-terminal 20 peptide (PAMP), hypotensive and vasodilating peptides. Peptides 2001; 22: 1693–711.

    Article  PubMed  CAS  Google Scholar 

  6. Mikkola T, Viinikka L, Ylikorkala O. Estrogen and postmenopausal estrogen/progestin therapy: effect on endothelium-dependent prostacyclin, nitric oxide and endothelin-1 production. Eur J Obstet Gynecol Reprod Biol 1998; 79: 75–82.

    Article  PubMed  CAS  Google Scholar 

  7. Thompson RS, Stevens RJ. Mathematical model for interpretation of Doppler velocity waveform indices. Med Biol Eng Comput 1989; 27: 269–76.

    Article  PubMed  CAS  Google Scholar 

  8. Speroff L, Glass RH, Kase NG. Clinical Gynecologic Endocrinology and Infertility. 6th ed. Lippincott William&Wilkins, USA, 1999: 643–724.

    Google Scholar 

  9. Mikkola T, Ranta V, Orpana A, Viinikka L, Ylikorkala O. Hormone replacement therapy modifies the capacity of plasma and serum to regulate prostacyclin and endothelin-1 production in human vascular endothelial cells. Fertil Steril 1996; 66: 389–93.

    PubMed  CAS  Google Scholar 

  10. Ylikorkala O, Cacciatore B, Paakkari I, Tikkanen MJ, Viinikka L, Toivonen J. The long-term effects of oral and transdermal post-menopausal hormone replacement therapy on nitric oxide, endothelin-1, prostacyclin, and thromboxane. Fertil Steril 1998; 69: 883–8.

    Article  PubMed  CAS  Google Scholar 

  11. Evans JJ, Youssef AH, Abbas MM, Schwartz J. GnRH and oxytocin have nonidentical effects on the cellular LH response by gonadotrophs at pro-oestrus. J Endocrinol 1999; 163: 345–51.

    Article  PubMed  CAS  Google Scholar 

  12. Hirata Y, Hayakawa H, Suzuki Y, et al. Mechanisms of adrenomedullin-induced vasodilation in the rat kidney. Hypertension 1995; 25: 790–5.

    Article  PubMed  CAS  Google Scholar 

  13. Kohno M, Kano H, Horio T, Yokokawa K, Yasunari K, Takeda T. Inhibition of endothelin production by adrenomedullin in vascular smooth muscle cells. Hypertension 1995; 25: 1185–90.

    Article  PubMed  CAS  Google Scholar 

  14. Miura K, Ebara T, Okumura M, et al. Attenuation of adrenomedullin-induced renal vasodilatation by NG-nitro L-arginine but not glibenclamide. Br J Pharmacol 1995; 115: 917–24.

    Article  PubMed  CAS  Google Scholar 

  15. Barker S, Corder R. Adrenomedullin acts as a local mediator of vascular homeostasis through interactions which lead to reduced endothelin-1 synthesis and secretion. J Hum Hypertens 1997; 11: 605–6.

    Article  PubMed  CAS  Google Scholar 

  16. Hillier C, Petrie MC, Love MP, Johnston F, Maclean MR, Mc-Murray JJ. Effect of adrenomedullin on the production of endothelin-1 and on its vasoconstrictor action in resistance arteries: evidence for a receptor-specific functional interaction in patients with heart failure. Clin Sci 2001; 101: 45–51.

    Article  PubMed  CAS  Google Scholar 

  17. Eguchi S, Hirata Y, Imai T, Marumo F. C-type natriuretic peptide upregulates vascular endothelin type B receptors. Hypertension 1994; 23: 936–40.

    Article  PubMed  CAS  Google Scholar 

  18. Vigne P, Lund L, Frelin C. Cross-talk among cyclic AMP, cyclic GMP, and Ca(2+)-dependent intracellular signaling mechanisms in brain capillary endothelial cells. J Neurochem 1994; 62: 2269–74.

    Article  PubMed  CAS  Google Scholar 

  19. Fixler R, Hasin Y, Eilam Y, Zhang DF, Nir A. Opposing effects of endothelin-1 on C-type natriuretic peptide actions in rat cardiomyocytes. Eur J Pharmacol 2001; 423: 95–8.

    Article  PubMed  CAS  Google Scholar 

  20. Sugo S, Itoh H, Komatsu Y, et al. Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cell- evidence for CNP as a novel autocrine/paracrine regulator from endothelial cells. Endocrinol 1993; 133: 3038–41.

    Article  Google Scholar 

  21. Ishihara T, Kato J, Kitamura K, et al. Production of adrenomedullin in human vascular endothelial cells. Life Sci 1997; 60: 1763–9.

    Article  PubMed  CAS  Google Scholar 

  22. Pham I, Sediame S, Maistre G, et al. Renal and vascular effects of C-type and atrial natriuretic peptides in humans. Am J Physiol 1997; 273: 1457–64.

    Google Scholar 

  23. Kurita A, Matsui T, Ishizuka T, Takase B, Satomura K. Significance of plasma nitric oxide/endothelial-1 for prediction of coronary artery disease. Angiology 2005; 56: 259–64.

    Article  PubMed  Google Scholar 

  24. Shimada N, Saka S, Sekizuka K, et al. Increased endothelin:nitric oxide ratio is associated with erythropoietin-induced hypertension in hemodialysis patients. Ren Fail 2003; 25: 569–78.

    Article  PubMed  CAS  Google Scholar 

  25. Slopien R, Junik R, Meczekalski B, et al. Influence of hormonal replacement therapy on the regional cerebral blood flow in post-menopausal women. Maturitas 2003; 46: 255–62.

    Article  PubMed  CAS  Google Scholar 

  26. Ungersböck K, Heimann A, Kempski O. Monitoring of cortical blood flow: Clinical relevance of experimental laser Doppler studies. Neurol Res 1996; 18: 273–6.

    PubMed  Google Scholar 

  27. Czosnyka M, Richards HK, Whitehouse HE, Pichard JD. Relationship between transcranial Doppler-determined pulsatility index and cerebrovascular resistance: an experimental study. J Neurosurg 1996; 84: 79–84.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Kirikkale University, Kirikkale

    Merih Bayram

  2. Department of General Surgery, Faculty of Medicine, Gazi University, Ankara

    Orhan Bayram

  3. Department of Radiology, Turkey

    M. Yasemin Karadeniz Bilgili

  4. Department of Biochemistry, Faculty of Medicine, Kirikkale University, Kirikkale

    Osman Caglayan

  5. Gazi University, Department of Public Health, Faculty of Medicine, Ankara, Turkey

    Mustafa N. Ilhan

Authors
  1. Merih Bayram
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Orhan Bayram
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Yasemin Karadeniz Bilgili
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Osman Caglayan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mustafa N. Ilhan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Merih Bayram.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bayram, M., Bayram, O., Bilgili, M.Y.K. et al. Evaluation of hormone replacement therapy which may have an adrenomedullin-mediated protective effect on cardiovascular disorders. Aging Clin Exp Res 19, 224–227 (2007). https://doi.org/10.1007/BF03324694

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03324694

Keywords

Search

Navigation