Skip to main content
Log in

Is there a role for real life observational studies in integrating knowledge provided by randomized clinical trials?

  • Point of View
  • Published:
Aging Clinical and Experimental Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Dowd R, Recker RR, Heaney RP. Study subjects and ordinary patients. Osteoporos Int 2000; 11: 533–6.

    Article  PubMed  CAS  Google Scholar 

  2. Hulley S, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 1998; 280: 605–13.

    Article  PubMed  CAS  Google Scholar 

  3. Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000; 342: 154–60.

    Article  PubMed  CAS  Google Scholar 

  4. Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 2000; 342: 1887–92.

    Article  PubMed  CAS  Google Scholar 

  5. Benson K, Hartz AJ. A comparison of observational studies and randomized, controlled trials. N Engl J Med 2000; 342: 1878–86.

    Article  PubMed  CAS  Google Scholar 

  6. Ioannidis JP, Haidich AB, Pappa M, et al. Comparison of evidence of treatment effects in randomized and nonrandomized studies. JAMA 2001; 286: 821–30.

    Article  PubMed  CAS  Google Scholar 

  7. Motheral BR, Fairman KA. The use of claims databases for outcomes research: rationale, challenges, and strategies. Clin Ther 1997; 19: 346–66.

    Article  PubMed  CAS  Google Scholar 

  8. Sacks H, Chalmers TC, Smith H Jr. Randomized versus historical controls for clinical trials. Am J Med 1982; 72: 233–40.

    Article  PubMed  CAS  Google Scholar 

  9. Langlois JA, Maggi S, Crepaldi G. Report of the Workshop on Hip Fracture Registries in Europe. Aging Clin Exp Res 2000; 12: 398–401.

    CAS  Google Scholar 

  10. Ayanian JZ. Using administrative data to assess health outcomes. Eur Heart J 1999; 20: 1689–91.

    Article  PubMed  CAS  Google Scholar 

  11. Gdalevich M, Cohen D, Yosef D, Tauber C. Morbidity and mortality after hip fracture: the impact of operative delay. Arch Orthop Trauma Surg 2004; 124: 334–40.

    Article  PubMed  Google Scholar 

  12. Huybrechts KF, Ishak KJ, Caro JJ. Assessment of compliance with osteoporosis treatment and its consequences in a managed care population. Bone 2006; 38: 922–8.

    Article  PubMed  Google Scholar 

  13. Watts NB, Worley K, Solis A, et al. Comparison of Risedronate to Alendronate and Calcitonin for early reduction of nonvertebral fracture risk: results from a managed care administrative claims database. JMCP 2004; 10: 142–51.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Maggi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Maggi, S., Scafato, E. Is there a role for real life observational studies in integrating knowledge provided by randomized clinical trials?. Aging Clin Exp Res 18, 274–276 (2006). https://doi.org/10.1007/BF03324661

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03324661

Key words

Navigation