Skip to main content
Log in

Replicative senescence of T lymphocytes: Effect on immune function

  • Symposiums Report
  • Lectures
  • Published:
Aging Clinical and Experimental Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Effros R.B., Walford R.L.T.: Cell cultures and the Hayflick Limit. Human Immunol. 9: 49–65, 1984.

    Article  CAS  Google Scholar 

  2. Perillo N.L., Walford R.L., Newman M.A., Effros R.B.: Human T lymphocytes possess a limited in vitro life span. Exp. Gerontol. 24: 177–187, 1989.

    Article  PubMed  CAS  Google Scholar 

  3. Gruebeck-Loebenstein B., Lechner H., Treib K.: Long-term in vitro growth of human T cell clones: Can post-mitotic ‘senescent’ cell populations be defined? Int. Arch. Immunol. 104: 232–239, 1994.

    Article  Google Scholar 

  4. Perillo N.L., Naeim F., Walford R.L., Effros R.B.: The in vitro senescence of human T lymphocytes: failure to divide is not associated with a loss of cytolytic activity or memory T cell phenotype. Mech. Ageing Dev. 67: 173–185, 1993.

    Article  PubMed  CAS  Google Scholar 

  5. Effros R.B., Boucher N., Porter V., Zhu X., Spaulding C., Walford R.L., Kronenberg M., Cohen D., Schachter F.: Decline in CD28+ T cells in centenarians and in long-term T cell cultures a possible cause for both in vivo and in vitro immunosenescence. Exp. Gerontol. 29: 601–609, 1994.

    Article  PubMed  CAS  Google Scholar 

  6. Effros R.B., Zhu X., Walford R.L.: Stress response of senescent T lymphocytes: reduced hsp70 is independent of the proliferative block. J. Gerontol. 49: B65–B70, 1994.

    Article  PubMed  CAS  Google Scholar 

  7. Vaziri H., Schachter F., Uchida I., Wei L., Zhu X., Effros R., Cohen D., Harley C.: Loss of telomeric DNA during aging of normal and trisomy 21 human lympocytes. Am. J. Hum. Genet. 52: 661–667, 1993.

    PubMed  CAS  Google Scholar 

  8. Harley C.B.: Telomere loss: mitotic clock or genetic time-bomb. Mutat. Res. 256: 271, 1991.

    Article  PubMed  CAS  Google Scholar 

  9. Miller R.A.: Aging and the immune response. In: Schneider E.L., Rowe J.W. (Eds.), Handbook of the biology of aging, ed. 3. Academic Press, New York, 1990, pp. 157–180.

    Chapter  Google Scholar 

  10. Effros R.B., Allsopp R., Chiu C-P., Wang L., Hirji K., Villeponteau B., West M., Giorgi J.: Lymphocyte replicative senescence in AIDS: telomere loss in the expanded CD28 CD8+ subset. (submitted for publication).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Effros, R.B. Replicative senescence of T lymphocytes: Effect on immune function. Aging Clin Exp Res 7, 464–466 (1995). https://doi.org/10.1007/BF03324366

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03324366

Keywords

Navigation