References
Effros R.B., Walford R.L.T.: Cell cultures and the Hayflick Limit. Human Immunol. 9: 49–65, 1984.
Perillo N.L., Walford R.L., Newman M.A., Effros R.B.: Human T lymphocytes possess a limited in vitro life span. Exp. Gerontol. 24: 177–187, 1989.
Gruebeck-Loebenstein B., Lechner H., Treib K.: Long-term in vitro growth of human T cell clones: Can post-mitotic ‘senescent’ cell populations be defined? Int. Arch. Immunol. 104: 232–239, 1994.
Perillo N.L., Naeim F., Walford R.L., Effros R.B.: The in vitro senescence of human T lymphocytes: failure to divide is not associated with a loss of cytolytic activity or memory T cell phenotype. Mech. Ageing Dev. 67: 173–185, 1993.
Effros R.B., Boucher N., Porter V., Zhu X., Spaulding C., Walford R.L., Kronenberg M., Cohen D., Schachter F.: Decline in CD28+ T cells in centenarians and in long-term T cell cultures a possible cause for both in vivo and in vitro immunosenescence. Exp. Gerontol. 29: 601–609, 1994.
Effros R.B., Zhu X., Walford R.L.: Stress response of senescent T lymphocytes: reduced hsp70 is independent of the proliferative block. J. Gerontol. 49: B65–B70, 1994.
Vaziri H., Schachter F., Uchida I., Wei L., Zhu X., Effros R., Cohen D., Harley C.: Loss of telomeric DNA during aging of normal and trisomy 21 human lympocytes. Am. J. Hum. Genet. 52: 661–667, 1993.
Harley C.B.: Telomere loss: mitotic clock or genetic time-bomb. Mutat. Res. 256: 271, 1991.
Miller R.A.: Aging and the immune response. In: Schneider E.L., Rowe J.W. (Eds.), Handbook of the biology of aging, ed. 3. Academic Press, New York, 1990, pp. 157–180.
Effros R.B., Allsopp R., Chiu C-P., Wang L., Hirji K., Villeponteau B., West M., Giorgi J.: Lymphocyte replicative senescence in AIDS: telomere loss in the expanded CD28− CD8+ subset. (submitted for publication).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Effros, R.B. Replicative senescence of T lymphocytes: Effect on immune function. Aging Clin Exp Res 7, 464–466 (1995). https://doi.org/10.1007/BF03324366
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03324366