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Telomerase expression in human cells and tissues

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References

  1. Greider C.W., Blackburn E.: A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331–337, 1989.

    Article  PubMed  CAS  Google Scholar 

  2. Morin G.B.: The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59: 521–529, 1989.

    Article  PubMed  CAS  Google Scholar 

  3. Watson J.: Origin of concatemeric T7 DNA. Nature New Biol. 239: 197–201, 1972.

    Article  PubMed  CAS  Google Scholar 

  4. Olovnikov A.: A theory of marginotomy: the incomplete copying of template margin in enzymatic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol. 41: 181–190, 1973.

    Article  PubMed  CAS  Google Scholar 

  5. Levy M.Z., Allsopp R.C., Futcher A.B., Greider C.W., Harley C.H.: Telomere end-replication problem and cell aging. J. Mol. Biol. 225: 951–960, 1992.

    Article  PubMed  CAS  Google Scholar 

  6. Harley C.B., Futcher A.B., Greider C.W.: Telomeres shorten during ageing of human fibroblasts. Nature 345: 458–460, 1990.

    Article  PubMed  CAS  Google Scholar 

  7. Counter C.M., Avilion A.A., LeFeuvre C.E., Stewart N.G., Greider C.W., Harley C.B., Bacchetti S.: Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11: 1921–1929, 1992.

    PubMed  CAS  Google Scholar 

  8. Counter C.M., Hirte H.W., Bacchetti S., Harley C.B.: Telomerase activity in human ovarian carcinoma. Proc. Natl. Acad. Sci. USA 91: 2900–2904, 1994.

    Article  PubMed  CAS  Google Scholar 

  9. Kim N.W., Piatyszek M.A., Prowse K.R., Harley C.B., West M.D., Ho P.L.C., Coviello G.M., Wright W.E., Weinrich S.L., Shay J.W.: Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011–2015, 1994.

    Article  PubMed  CAS  Google Scholar 

  10. Lansdorp P.M., Dragowska W.: Long-term erythropoiesis from constant numbers of CD34+ cells in serum-free cultures initiated with highly purified progenitor cells from human bone marrow. J. Exp. Med. 175: 1501–1509, 1992.

    Article  PubMed  CAS  Google Scholar 

  11. Vaziri H., Dragowska W., Allsopp R.C., Thomas T.E., Harley C.B., Lansdorp P.M.: Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc. Natl. Acad. Sci. USA 91: 9857–9860, 1994.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Research Geron Corporation, Menlo Park, California, USA

    C. P. Chiu, N. W. Kim, K. R. Prowse & C. B. Harley

  2. The Terry Fox Laboratory, Vancouver, British Columbia, Canada

    W. H. Dragowska, T. E. Thomas & P. Lansdorp

Authors
  1. C. P. Chiu
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  2. N. W. Kim
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  3. K. R. Prowse
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  4. W. H. Dragowska
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  5. T. E. Thomas
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  6. P. Lansdorp
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  7. C. B. Harley
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Chiu, C.P., Kim, N.W., Prowse, K.R. et al. Telomerase expression in human cells and tissues. Aging Clin Exp Res 7, 460–461 (1995). https://doi.org/10.1007/BF03324363

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