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Age differences in biochemical and hematological measures during middle age

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Abstract

Biochemical and hematological measures possibly associated with ageing were measured on a single occasion in 3402 male and 2152 female London Civil Servants aged from 35 to 59 years of age. These included erythrocyte sedimentation rate (ESR), blood hemoglobin and serum albumin, calcium, bilirubin, creatinine, urea, urate, high density lipoprotein (HDL), and total cholesterol. Independently and positively related to age were ESR with an estimated 47% ‘increase’ in men over the 15 years between ages 40 to 55 and a 40% increase in women; serum urea had a 6%/15- year increase in men and 20% in women; total cholesterol had a 6% /15- year increase in men and 18% in women; serum creatinine ‘increased’ by 2% /15- years in men and 5% in women. In women, urate, HDL cholesterol and hemoglobin increased with age group. Negatively related to age was serum bilirubin in both sexes (8% and 6% ‘fall’/15- years in men and women respectively). Serum albumin and calcium fell with age group in men. The sexes differed in their relationship to aging for total cholesterol and HDL cholesterol (greater increase in women), serum calcium (small decrease in men and small increase in women), urate and hemoglobin (increases in women but not men). Urea increased more in women than men, and albumin decreased more in men than women (p<0.001 for all comparisons with the exception of HDL cholesterol, p<0.01). Changes during the menopause were thought to explain some of these findings. (Aging Clin. Exp. Res. 6: 359–367, 1994)

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References

  1. Markowe H.L.J., Marmot M.G., Shipley M.J., Bulpitt C.J., Meade T.W., Stirling Y., Vickers M.V., Semmence A.: Fibrinogen: a possible link between social class and coronary heart disease. Br. Med. J. 2 ed. 291: 1312–1314, 1984.

    Article  Google Scholar 

  2. Bulpitt C.J., Broughton P.M.G., Markowe H.L.J., Marmot M.G., Rose G., Semmence A., Shipley M.J.: The relationship between both sodium and potassium intake and blood pressure in London Civil Servants: a report from the Whitehall Department of Environment Study. J. Chron. Dis. 39: 211–219, 1986.

    Article  PubMed  CAS  Google Scholar 

  3. Staessen J., Yeoman W.B., Fletcher A.E., Markowe H.L.J., Marmot M.G., Rose G., Semmence A., Shipley M.J., Bulpitt C.J.: Blood lead concentration, renal function, and blood pressure in London civil servants. Br. J. Ind. Med. 47: 442–447, 1990.

    PubMed  CAS  Google Scholar 

  4. Staessen J., Yeoman W.B., Fletcher A.E., Markowe H.L.J., Marmot M.G., Rose G., Semmence A., Shipley M.J., Bulpitt C.J.: Blood cadmium in London Civil Servants. Int. J. Epidemiol 19: 362–366, 1990.

    Article  PubMed  CAS  Google Scholar 

  5. Staessen J., Broughton P.M.G., Fletcher A.E., Markowe H.L.J., Marmot M.G., Rose G., Semmence A., Shipley M.J., Bulpitt C.J.: The assessment of the relationship between blood pressure and sodium intake using whole-day daytime and overnight urine collections. J. Hypertens. 9: 1035–1040, 1991.

    Article  PubMed  CAS  Google Scholar 

  6. Bulpitt C.J., Shipley M.J., Broughton P.M.G., Fletcher A.E., Markowe H.L.J., Marmot M.G., Semmence A., Rose G.: The assessment of biological age. A report from the Department of Environment Study. Aging Clin. Exp. Res. 6: 181–191, 1994.

    Article  CAS  Google Scholar 

  7. Rose G.A., Blackburn H.: Cardiovascular survey methods, WHO Monograph Series, No. 56. World Health Organisation, Geneva, 1986.

    Google Scholar 

  8. Bulpitt C.J., Rowntree R.K., Semmence A.: A randomised controlled trial of the effects of screening for ulcer-type dyspepsia. J. Epidemiol. Comm. Health 36: 172–175, 1982.

    Article  CAS  Google Scholar 

  9. Bulpitt C.J., Shipley M.J., Semmence A.: The contribution of a moderate intake of alcohol to the presence of hypertension. J. Hypertens. 5: 85–91, 1987.

    Article  PubMed  CAS  Google Scholar 

  10. Walton K.W.: Atherosclerosis and Ageing. In: Brocklehurst J.C. (Ed.), Textbook of Geriatric Medicine and Gerontology, ed. 3. Publ. Churchill Livingstone, Edinburgh, 1985, pp. 171–200.

    Google Scholar 

  11. Keys A.: The age trend of serum concentrations of cholesterol and of Sf 10-20 (“G”) substrates in adults. J. Gerontol. 7: 201–206, 1952.

    Article  PubMed  CAS  Google Scholar 

  12. Damon A.: Predicting age from body measurements and observations. Int. J. Aging Hum. Dev. 3: 169–174, 1972.

    Article  Google Scholar 

  13. Rose C.L.: The measurement of social age. Int. J. Aging Hum. Dev. 3: 153–168, 1972.

    Article  Google Scholar 

  14. Costa P.T. Jr, McCrae R.R.: Functional Age: Conceptual and Empirical Critique. In: Haynes S.G., Feinleib M. (Eds.), Second Conference on the Epidemiology of Aging, Washington DC, U. S. Government Printing Office, pp. 23–50, 1980.

    Google Scholar 

  15. National Center for Health Statistics. Vital and Health Statistics. Series II, Number 242. U.S. Department of Health and Human Services. Pub. No. (PHS) 93-1692. U.S. Government Printing Office, March 1993.

  16. Leask R.G.S., Andrews G.R., Caird F.I.: Normal values for sixteen blood constituents in the elderly. Age Ageing 2: 14–23, 1976.

    Article  Google Scholar 

  17. National Center for Health Statistics. Haematological and Nutritional Biochemistry. Reference Data for Persons 6 months-74 years of Age: United States, 1976–80. Vital and Health Statistics. Series II, Number 232. U.S. Government Printing Office, December 1982.

  18. Borkan G.A., Norris A.H.: Assessment of biological age using a profile of physical parameters. J. Gerontol. 35: 177–184, 1980.

    Article  PubMed  CAS  Google Scholar 

  19. Hodkinson H.M.: Serum calcium in a geriatric inpatient population. Age Ageing 2: 157–162, 1973.

    Article  PubMed  CAS  Google Scholar 

  20. MacLennan W.J., Martin P., Mason B.J.: Protein intake and serum albumin levels in the elderly. Gerontology 23: 360–367, 1977.

    Article  PubMed  CAS  Google Scholar 

  21. Gersovitz M., Munro H.N., Udall Y., Young V.R.: Albumin synthesis in young and elderly subjects using a new stable isotope methodology response to level of protein intake. Metabolism 29: 1075–1086, 1980.

    Article  PubMed  CAS  Google Scholar 

  22. Banerjee A.K., Brocklehurst J.C., Swidell R.: Protein status in long-stay geriatric in-patients. Gerontology 27: 161–166, 1981.

    Article  PubMed  CAS  Google Scholar 

  23. Wilding P., Rollason J.G., Robinson D.: Patterns of change for various biochemical constituents detected in well population screening. Clin. Chim. Acta 41: 375–387, 1972.

    Article  PubMed  CAS  Google Scholar 

  24. Roberts L.B.: The normal ranges, with statistical analysis for seventeen blood constituents. Clin. Chim. Acta 16: 69–78, 1967.

    Article  PubMed  CAS  Google Scholar 

  25. Keating F.R., Jones J.D., Elveback L.R., Randall R.V.: The relation of age and sex to distribution in healthy adults of serum calcium, inorganic phosphorous, magnesium, alkaline phosphatase, total proteins, albumin and blood urea. J. Lab. Clin. Med. 73: 825–834, 1969.

    PubMed  CAS  Google Scholar 

  26. Reed A.H., Cannon D.C., Winkelman J.W., Bhasin Y.P., Henry R.J., Pileggi V.J.: Estimation of normal ranges from a controlled sample survey: sex and age related influence on SMA 12/60 group of tests. Clin. Chem. 18: 57–66, 1972.

    PubMed  CAS  Google Scholar 

  27. Hodkinson H.M.: Calcium, phosphate and the investigation of metabolic bone disease. In: Hodkinson H.M. (Ed.), Clinical Biochemistry of the Elderly. Publ. Churchill Livingstone, Edinburgh, 1984, pp. 139–152.

    Google Scholar 

  28. Sharland D.E.: Serum alkaline phosphatase: the levels and patterns of isolated enzymes in the non-hospitalised elderly. Age Ageing I: 168–176, 1972.

    Article  Google Scholar 

  29. Kampmann J.P., Sinding J., Moller-Jorgensen I.: Effect of age on liver function. Geriatrics 30: 91–95, 1975.

    PubMed  CAS  Google Scholar 

  30. Chan-Yeung M., Ferreira P., Frohlich J., Schulzer M., Tan F.: The effect of age, smoking and alcohol on routine laboratory tests. Am. J. Clin. Pathol. 75: 320–326, 1981.

    PubMed  CAS  Google Scholar 

  31. Rowe J.W., Andres R., Tobin J.D., Norrish A.H., Shock N.W.: The effect of age on creatinine clearance in men — a cross-sectional and longitudinal study. J. Gerontol. 31: 157–163, 1976.

    Google Scholar 

  32. Kafetz K.: Uraemia in congestive cardiac failure; the response to diuresis and relationship to liver function. J. Clin. Exp. Gerontol. 4: 257–265, 1982.

    Google Scholar 

  33. Denham M.J., Hodkinson H.M., Fisher M.: Glomerular filtration rate in the sick elderly in-patients. Age Ageing 4: 32–36, 1975.

    Article  PubMed  CAS  Google Scholar 

  34. Goodman L.S., Gilman A.: The Pharmacological Basis of Therapeutics, ed. 5. Macmillan, New York, 1975, p. 568.

    Google Scholar 

  35. Cheraskin E., Ringdorf W.M., Medford B.S.: The eating habits of smokers and non smokers. J. Int. Acad. Press. Med. 2: 9–17, 1975.

    Google Scholar 

  36. Hodkinson H.M.: Biochemical diagnosis of the elderly. Chapman & Hall, London, 1977.

    Google Scholar 

  37. Freeman H., Cox M.L.: Plasma proteins. In: Hodkinson M. (Ed.), Clinical Biochemistry of the Elderly. Publ. Churchill Livingstone, Edinburgh, 1984, pp. 46–74.

    Google Scholar 

  38. Bulpitt C.J.: Serum uric acid in hypertensive patients. Br. Heart J. 37: 2120–2126, 1975.

    Article  Google Scholar 

  39. Sharland D.E.: Erythrocyte sedimentation rate; the normal range in the elderly. J. Am. Geriatr. Soc. 28: 346–348, 1980.

    PubMed  CAS  Google Scholar 

  40. Gilbertson V.A.: Erythrocyte sedimentation rates in older patients: a study of 4341 cases. Postgrad. Med. J. 38: A44–52, 1965.

    Google Scholar 

  41. Hayes G.S., Stinson I.N.: Erythrocyte sedimentation rate and age. Arch. Ophthalmol. 94: 939–940, 1976.

    Article  PubMed  CAS  Google Scholar 

  42. Sparrow D., Rowe J.W., Gilbert J.E.: Cross-sectional and longitudinal changes in the erythrocyte sedimentation rate in men. J. Gerontol. 36: 180–184, 1981.

    Article  PubMed  CAS  Google Scholar 

  43. Shearn M.A., Kang I.Y.: Effect of age and sex on the Erythrocyte Sedimentation Rate. J. Rheumatol. 13: 297–298, 1986.

    PubMed  CAS  Google Scholar 

  44. Hawkins W.W., Speck E., Leonard V.G.: Variation of the haemoglobin level with age and sex. Blood 9: 999–1007, 1954.

    PubMed  CAS  Google Scholar 

  45. Elwood P.C.: Epidemiological aspects of iron deficiency in the elderly. Gerontologia Clinica 13: 2–11, 1971.

    Article  PubMed  CAS  Google Scholar 

  46. Milne J.S., Williamson J.: Haemoglobin, haematocrit-reading, leucocyte count and blood grouping in a random sample of older people. Geriatrics 27: 118–126, 1972.

    PubMed  CAS  Google Scholar 

  47. Brunning R.: Differential diagnosis of anaemia. Geriatrics 29: 52–60, 1974.

    PubMed  CAS  Google Scholar 

  48. Semmence A.: Anaemia in the Elderly. Br. Med. J. II: 1153–1154, 1959.

    Article  Google Scholar 

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Authors and Affiliations

  1. Division of Geriatric Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London, W12 ONN, UK

    C. J. Bulpitt

  2. Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, London

    M. J. Shipley, A. E. Fletcher, H. L. J. Markowe & M. G. Marmot

  3. Wolfson Research Laboratories, Queen Elizabeth Medical Centre, Birmingham

    P. M. G. Broughton

  4. Cabinet Office (Office of the Minister for the Civil Service), Medical Advisory Service, Edinburgh

    A. Semmence

  5. Department of Epidemiology and Public Health, University College, London, United Kingdom

    M. J. Shipley, H. L. J. Markowe & M. G. Marmot

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  1. C. J. Bulpitt
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  2. M. J. Shipley
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  4. A. E. Fletcher
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  6. M. G. Marmot
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  7. A. Semmence
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Bulpitt, C.J., Shipley, M.J., Broughton, P.M.G. et al. Age differences in biochemical and hematological measures during middle age. Aging Clin Exp Res 6, 359–367 (1994). https://doi.org/10.1007/BF03324266

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  • DOI: https://doi.org/10.1007/BF03324266

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