Skip to main content
SpringerLink
Log in

Longitudinal study of the hematocrit of ad libitum fed and dietary restricted male F344 rats

  • Original Article
  • Published:
Aging Clinical and Experimental Research Aims and scope Submit manuscript

Abstract

A longitudinal study of age- change in the hematocrit (Hct) was conducted with ad libitum fed and dietary restricted male F344 rats. A progressive fall in Hct occurred over the age range of 3 to 20 months. The magnitude of this decrease in Hct was similar in ad libitum fed and dietary restricted rats. Whether this age- associated decline in Hct continues after 20 months of age cannot be answered with certainty because of the occurrence of diseases at advanced ages which can mask or exacerbate the effects of the aging processes on the Hct. Studies of similar design with males and females of other strains of rats are needed to establish that a decreasing Hct is characteristic of aging in this species. (Aging Clin. Exp. Res. 6: 287–292, 1994)

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Boggs S.S., Patrene K.D., Austin C.A., Vecchini F., Tollerud D.J.: Latent deficiency of the hematopoietic microenvironment of aged mice as revealed in W/Wv mice given +/+ cells. Exp. Hematol. 19: 683–687, 1991.

    PubMed  CAS  Google Scholar 

  2. Finch C.E., Foster J.R.: Hematologic and serum electrolyte values of the C57BL/6J male mouse in maturity and senescence. Lab. Anim. Sci. 23: 339–349, 1973.

    PubMed  CAS  Google Scholar 

  3. Silini C., Andreozzi U.: Haematologic changes in the ageing mouse. Exp. Gerontol. 9: 99–108, 1974.

    Article  PubMed  CAS  Google Scholar 

  4. Talbot R.B., Abel M.B., Davison F.C.: Age changes in blood parameters of C57BL mice. Lab. Anim. Care 15: 392–396, 1965.

    Google Scholar 

  5. Williams L.H., Udupa K. B., Lipschitz D.A: Evaluation of the effect of age on hematopoiesis in the C57 BL/6 mouse. Exp. Hematol. 14: 827–832, 1986.

    PubMed  CAS  Google Scholar 

  6. Boggs D.R., Patrene K.D.: Hematopoiesis and aging. III. Anemia and a blunted erythropoietic response to hemorrhage in aged mice. Am. J. HematoL 19: 327–338, 1985.

    CAS  Google Scholar 

  7. Boggs D.R., Patrene K.: Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice. Exp. Aging Res. 12: 131–134, 1986.

    CAS  Google Scholar 

  8. Ewing K.L., Tauber O.E.: Hematological changes in aging male C57BL/6 JAX mice. J. Gerontol. 19: 165–167, 1964.

    Article  PubMed  CAS  Google Scholar 

  9. Helman N., Rubenstein L.S.: The effects of age, sex, and smoking on erythrocytes and leukocytes. Am. J. Clin. Pathol. 63: 35–44, 1975.

    PubMed  CAS  Google Scholar 

  10. Olbrich O.: Blood changes in the aged. Edinburgh Med. J. 54: 306–332, 1947.

    CAS  Google Scholar 

  11. Zauber N.P., Zauber A.G.: Hematologic data of healthy very old people. JAMA 257: 2181–2184, 1987.

    Article  PubMed  CAS  Google Scholar 

  12. Timeras M., Brownstein H.: Prevalence of anemia and correlation of hemoglobin with age in geriatric screening clinic population. J. Am. Geriatr. Soc. 35: 639–643, 1987.

    Google Scholar 

  13. Kelley A., Munan L.: Hematologic profile of natural populations: Red cell parameters. Br. J. Haematol. 35: 153–160, 1977.

    Article  Google Scholar 

  14. Grunt J.A., Berry R.J., Knisely W.H.: Effects of castration and/or hormonal therapy upon the hematocrit in aged male rats. J. Gerontol. 13: 359–366, 1958.

    Article  PubMed  CAS  Google Scholar 

  15. Grant W.C., LeGrande A.M.: The influence of age and erythropoiesis in the rat. J. Gerontol. 19: 505–509, 1964.

    Article  PubMed  CAS  Google Scholar 

  16. Ring G.C., Kurabatov B.A., Hernandez G.G.: Changes in erythrocytes related to the aging of rats. J. Gerontol. 19: 352–356, 1964.

    Article  PubMed  CAS  Google Scholar 

  17. Smith D., Bronson R.: Clinical chemistry and hematology profile of the aging rat. Lab. Anim. 21: 32–46, 1992.

    CAS  Google Scholar 

  18. Masoro E.J.: Dietary restriction and aging. J. Am. Geriatr. Soc. 41: 994–999, 1993.

    PubMed  CAS  Google Scholar 

  19. Yu B.P., Masoro E.J., McMahan C.A.: Nutritional influences on aging of Fischer 344 rats. I. Physical, metabolic and longevity characteristics. J. Gerontol. 40: 657–670, 1985.

    CAS  Google Scholar 

  20. Bertrand H.A., Lynd F.T., Masoro E.J., Yu B.P.: Changes in adipose mass and cellularity through the adult life of rats fed ad libitum or a life-prolonging restricted diet. J. Gerontol. 35: 827–835, 1980.

    Article  PubMed  CAS  Google Scholar 

  21. Keith L.D., Winslow J.R., Reynolds R.W.: A general procedure for estimation of corticosteroid response in individual rats. Steroids 31: 523–531, 1978.

    Article  PubMed  CAS  Google Scholar 

  22. Iwasaki K., Gleiser C.A., Masoro E.J., McMahan CA., Seo E., Yu B.P.: The influence of dietary protein source on longevity and age-related disease processes of Fischer 344 rats. J. Gerontol. 43: B5–B12, 1988.

    Article  PubMed  CAS  Google Scholar 

  23. Yu B.P., Masoro E.J., Murata L., Bertrand H.A., Lynd FT.: Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: Longevity, growth, lean body mass and disease. J. Gerontol. 37: 130–141, 1982.

    Article  PubMed  CAS  Google Scholar 

  24. Maeda H., Gleiser C.A., Masoro E.J., Murata I., McMahan CA., Yu B.P.: Nutritional influences on aging of Fischer 344 rats: II. Pathology. J. Gerontol. 40: 671–688, 1985.

    Article  CAS  Google Scholar 

  25. Shimokawa I., Higami Y., Hubbard G.B., McMahan CA., Masoro E.J., Yu B.P.: Diet and the suitability of the male Fischer 344 rat as a model for aging research. J. Gerontol. 48: B27–B32, 1993.

    Article  PubMed  CAS  Google Scholar 

  26. Winer B.J.: Statistical principles in experimental design. McGraw Hill, New York, 1971.

    Google Scholar 

  27. Weindruch R., Walford R.: The retardation of aging and disease by dietary restriction. Charles C Thomas, Springfield, IL, 1988.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas, 78284-7756, USA

    Edward J. Masoro Ph.D. & B. R. Yu

  2. Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

    C. A. McMahan

  3. First Department of Pathology, Nagasaki University School of Medicine, Nagasaki, Japan

    I. Shimokawa & Y. Higami

Authors
  1. Edward J. Masoro Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. A. McMahan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. Shimokawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y. Higami
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. R. Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Masoro, E.J., McMahan, C.A., Shimokawa, I. et al. Longitudinal study of the hematocrit of ad libitum fed and dietary restricted male F344 rats. Aging Clin Exp Res 6, 287–292 (1994). https://doi.org/10.1007/BF03324254

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03324254

Keywords

Search

Navigation