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“On the suggestion of Dr. Alzheimer I examined the following four cases.” Dedicated to Gaetano Perusini

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Abstract

Gaetano Perusini merits a great deal more credit for his work on the elaboration of the concepts regarding what is now called Alzheimer’s disease (AD). Perusini’s work in Alzheimer’s laboratory and his subsequent studies have been, if not neglected, largely unmentioned. This article is an attempt to report a fascinating piece of medical history in order to redress the balance. Surely, Perusini’s work deserves to be reexamined. The same applies to Fischer’s investigation. Some of the puzzles discussed by Perusini are still unresolved. (Aging Clin. Exp. Res. 5: 135- 139, 1993)

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References

  1. Fischer O.: Miliare Nekrosen mit drusigen Wucherungen der Neurofibrillen, eine regelmaessige Veraenderung der Hirnrinde bei soniler Demenz. Monatsschrift fuer Psych, und Neuroi Bd. XXII: 361–372, 1907.

    Google Scholar 

  2. Krapelin E.: Lehrbuch der Psychiatrie, II Band, I Teil. Verlag von Johann Ambrosius Barth, Leipzig, 1910, pp.619–627.

    Google Scholar 

  3. Amaducci L., Rocca W.A., Schoenberg B.S.: Origin of the distinction between Alzheimer’s disease and senile dementia: How history can clarify nosology. Neurology 36: 1497–1499, 1986.

    Article  PubMed  CAS  Google Scholar 

  4. Alzheimer A.: Über eine eigenartige Erkrankung der Hirnrinde. Allgemeine Zeitschrift für Psychiatrie und Psychisch-Gerichtliche Medizin LXIV: 146–148, 1907.

    Google Scholar 

  5. Bonfiglio F.: Di speciali reperti in un caso di probabile sifilide cerebrale. Riuista Sperimentale di Freniatha e Medicina Legale delle Alienazioni Mentali XXXIV: 196–206, 1908.

    Google Scholar 

  6. Perusini G.: Sul valore nosografico di alcuni reperti istopatologici caratteristici per la senilità. Riuista italiana di Neuropatologia, Psichiatria e Elettroterapia, Vol. IV: 145–151, 1911.

    Google Scholar 

  7. Alzheimer A.: Ueber eigenartige Krankheitsfaelle des spaeteren Alters. Zeitschr. fuer die gesamte Neurologie und Psychiatrie, Bd. IV, Heft, 3, 1911.

    Google Scholar 

  8. Alzheimer A.: On certain peculiar diseases of old age. In: History of Psychiatry. Translated and with an introduction by H. Förstl and R. Levy. Alpha Academic, London, ii, 1991, 71–101.

    Google Scholar 

  9. Alzheimer A.: Über eine eigenaratige Erkrankung der Hirnrinde. XXXVII Verammlung südwestdeutscher Irrenärzte in Tübingen am 3 and 4 Nov 1906. Neurologisches Centralblatt, 1134, 1906.

  10. Blocq P., Marinesco G.: Sur les lésions et la pathogénie de l’épilepsie dite essentielle. Semaine Medical November 1892, 12, 445–446.

    Google Scholar 

  11. Redlich E.: Ueber miliare Sklerose der Hirnrinde bei seniler Atrophie. Jahrbucher für Psychiatrie und Neurologie. Bd. XVII: 361–372, 1898.

    Google Scholar 

  12. Perusini G.: Ueber ein Fall von Sclerosis tuberosa hypertrophica, Tabes dorsalis, Taboparalyse oder myelitis? Monatschrift für psychiatrie und Neurologie. Bd. XX, H.6, 1906.

    Google Scholar 

  13. Perusini G.: Über die Veraenderungen des Achsenzylinders und der Markscheide im Rueckenmarck bei der Formolfixierung. Zeitschrift fuer Heilkunde. Bd. XXVII, H. 7, 1906.

    Google Scholar 

  14. Perusini G.: Two cases of familial heredo-spinal atrophy (Friedreich’s type) with one autopsy and one case of so called abortive form of Friedreich’s disease. Journal of Mental Pathology, Vol. VI, N.l-2, 3–4 and 5, 1904.

    Google Scholar 

  15. Perusini G.: Il problema antropometrico del cretinismo endemico. Riv. Sperim. di Freniatria, Vol. XXXII, Fasc. III-IV, 1906; A cretin dog and its Thyroid apparatus. The J. Mental Pathology, Vol.VII, N.5, 1906; La ghiandola tiroide nei fanciulli delle scuole di Roma e dei paesi ad endemia gozzo-cretinica. Rendiconti della Reale Accademia dei Lincei, Vol. XV, 2° num., Serie 5.a, Fasc. 4°e 5°, 1907.

  16. Perusini G.: Ueber klinisch und histologisch eigenartige psychische Erkrankung des spaeteren Lebensalters. In: Nissl F., Alzheimer A. (Eds.), Histologische und Histopathologische Arbeiten.: Bd. III, H 2:197–351, 1910.

    Google Scholar 

  17. Vogels O.J.M., Broere C.A.J., Ter Laak H.J., Ten Donkelaar H.J., Nieuwenhuys R., Schulte B.P.M.: Cell loss and shrinkage in the nucleous basalis Meynert complex in Alzheimer’s disease. Neurobiol. Aging 11: 3–13, 1990.

    Article  PubMed  CAS  Google Scholar 

  18. Pardrige W.M.: Amyloid Angiopathy: Future Treatment Strategies. In: Cummings J.L., Miller B.L. (Eds.), Alzheimer’s Disease. Marcel Dekker, Inc. New York, 1990, pp. 339–351.

    Google Scholar 

  19. Glenner G.G., Wong C.W.: Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120: 885–890, 1984.

    Article  PubMed  CAS  Google Scholar 

  20. Wong C.W., Quaranta V., Glenner G.G.: Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related. P.N.A.S. 82: 8729–8732, 1984.

    Article  Google Scholar 

  21. McMenemey W.H.: Alois Alzheimer and his disease. In: Wolstenholme G.E., O’Connor M. (Eds.), Alzheimer’s disease. Ciba Fundation. J. & A. Churchill, London, 1970, pp.5–9.

    Google Scholar 

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  1. Biochemistry Department, Catholic University, School of Medicine, Largo F. Vito 1, 00168, Roma, Italy

    M. Pomponi & M. Marta

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  1. M. Pomponi
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  2. M. Marta
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Pomponi, M., Marta, M. “On the suggestion of Dr. Alzheimer I examined the following four cases.” Dedicated to Gaetano Perusini. Aging Clin Exp Res 5, 135–139 (1993). https://doi.org/10.1007/BF03324140

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