References
Wallace D.C.: Diseases of the mitochondrial DNA. Ann. Rev. Biochem. 61: 1175–1212, 1992.
Lestienne P.: Mitochondrial DNA mutations in human diseases: a review. Biochimie 74: 123–130, 1992.
Müller-Höcker J.: Cytochrome c oxidase deficient cardiomyocytes in the human heart. An age-related phenomenon. Am. J. Pathol. 134: 1167–1171, 1989.
Müller-Höcker J.: Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration. J. Neurol. Sci. 100: 14–21, 1990.
Müller-Höcker J., Schneiderbanger K., Stefani F.H., Kadenbach S.: Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing — a cytochemical-immunochemical study. Mutation Res. 275: 115–124, 1992.
Linnane A.W., Marzuki S., Ozawa T., Tanaka M.: Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet I: 642–645, 1989.
Kadenbach B., Müller-Höcker J.: Mutations of mitochondrial DNA and human death. Naturwissch. 77: 221–225, 1990.
Miquel J., Economos A.C., Fleming J., Johnson J.E.: Mitochondrial role in cell ageing. Exper. Gerontol. 15: 575–591, 1980.
Harman A.: Free radical theory of ageing: Consequences of mithocondrial ageing. Age 6: 86–94, 1983.
Nohl H.: The biochemical mechanism of the formation of reactive oxygen species in heart mithocondria. In: Caldarera C.M., Harris P. (Eds.), Advances in Studies on Heart Metabolism. Clueb, Bologna, 1982, pp. 413–421.
Wallace D.C., Singh G., Lott M., Hodge T.G., Lezza A.M.J., Elsas I.I.L.J., Nikoskelainen E.K.: Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy. Science 242: 1427–1430, 1988.
Shoffner J.M., Lott M.T., Lezza A.M.S., Seibel P., Ballinger S.W., Wallace D.C.: Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mithocondrial DNA tRNALys mutation. Cell 61: 931–937, 1990.
Seibel P., Degoul F., Bonne G., Romero N., François D., Paturneau-Jouas M., Ziegler F., Eymard B., Fardeau M., Marsac C., Kadenbach B.: Genetic, biochemical and pathophysiological characterization of a familial mithocondrial encephalomyopathy (MERRF). J. Neurol. Sci. 105: 217–224, 1991.
Goto Y., Nonaka I., Horai S.: A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature 348: 651–653, 1990.
Kobayashi Y., Momoi M.Y., Tominaga K., Momoi T., Nihei K., Yanagishawa M., Kagawa Y., Ohta S.: A point mutation in the mitochondrial tRNALeu(UUR)su gene in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes). Biochem. Biophys. Res. Comm. 173: 816–822, 1990.
Holt I.J., Harding A.E., Morgan-Hughes J.A.: Deletions of muscles mitochondrial DNA in patients with mitochondrial myopathies. Nature 331: 717–719, 1988.
Moraes C.T., DiMauro S., Zeviani M., Lombes A., Shanske S., Miranda F., Nakase H., Bonilla E., Werneck L.C., Servidei S., Nonaka L, Koga Y., Spiro A., Brownell K.W., Schmidt K.W., Schotland D.L., Zupanc M., deVivo D.C., Schon E.A., Rowland L.P.: Mitochondrial DNA deletions in progressive external opthalmoplegia and Kearns-Sayre-Syndrome. N. Engl. J. Med. 320: 1293–1299, 1989.
Lauber J., Marsac C., Kadenbach B., Seibel P.: Mutations in mitochondrial tRNA genes: a frequent cause of neuromuscular diseases. Nucleic Acids Res. 19: 1393–1397, 1991.
Cortopassi G.A., Arnheim N.: Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res. 18: 6927–6933, 1990.
Ikebe S., Tanaka M., Ohno K., Sato W., Hattori K., Kondo T., Mizuno Y., Ozawa T.: Increase of deleted mitochondrial DNA in the striatum in Parkinson’s disease and senescence. Biochem. Biophys. Res. Commun. 170: 1044–1048, 1990.
Linnane A.W., Baumer A., Maxwell R.J., Preston H., Zhang C., Marzuki S.: Mitochondrial gene mutation: The ageing process and degenerative disease. Biochem. 22: 1067–1076, 1990.
Sugiyama S., Hattori K., Hayakawa M., Ozawa T.: Quantitative analysis of age associated accumulation of mitochondrial DNA with deletion in human hearts. Biochem. Biophys. Res. Commun. 180: 894–899, 1991.
Yen Tch., Su J.H., King K.L., Wei Y.H.: Ageing associated 5kb deletion in human liver mitochondrial DNA. Biochem. Biophys. Res. Commun. 178: 124–131, 1991.
Münscher C., Rieger T., Müller-Höcker J., Kadenbach B.: The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different age. FEBS Lett., 1993 (in press).
Van den Ouweland J., Bruining G.J., Lindhout D., Wit J.-M., Veldhuyzen B.F.E., Maassen J.A.: Mutations in mitochondrial tRNA genes: non-linkage with syndromes of Wolfram and chronic external opthalmoplegia. Nucleic Acids Res. 20: 679–682, 1992.
Osiewacz H.D., Hermanns J.: The role of mitochondrial DNA rearrangements in aging and human disease. Aging Clin. Exp. Res. 4: 273–286, 1992.
Linnane A.W.: Mitochondria and aging: The universality of bioenergetic disease. Aging Clin. Exp. Res. 4: 267–271, 1992.
Seibel P., Mell O., Hannemann A., Müller-Höcker J., Kadenbach B.: A method for quantitative analysis of deleted mitochondrial DNA by PCR in small tissue samples. Meth. Mol. Biol. 2: 147–153, 1991.
Johnson M.A., Kadenbach B., Droste M., Old S.L., Turnbull D.M., Sherratt H.S.A.: Immunocytochemical studies of cytochrome c oxidase subunits in skeletal muscle of patients with partial cytochrome oxidase deficiences. J. Neurol. Sci. 87: 75–90, 1988.
Menzies R.A., Gold P.H.: The turnover of mitochondria in a variety of tissues of young adult and aged rats. J. Biol. Chem. 246: 2425–2429, 1971.
Bresolin N., Moggio M., Bet L., Gallanti A., Prelle A., Nobile-Orazio E., Adobbati L., Ferrante C., Pellegrini G., Scarlato G.: Progressive cytochrome c oxidase deficiency in a case of Kearns-Sayre Syndrome: morphological, immunological and biochemical studies in muscle biopsies and autopsy tissues. Ann. Neurol. 21: 564–572, 1987.
Hayashi J.I., Ohta S., Kikuchi A., Takemitsu M, Goto Y., Nonaka I.: Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proc. Natl. Acad. Sci. USA 88: 10614–10618, 1991.
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Kadenbach, B., Münscher, C. & Müller-Höcker, J. Mutations of mitochondrial DNA support human aging. Aging Clin Exp Res 5, 73–75 (1993). https://doi.org/10.1007/BF03324129
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DOI: https://doi.org/10.1007/BF03324129