Abstract
The aim of this study was to ascertain if the hemorheological profiles in 35 elderly and 20 young to middle-aged patients returned to normal after bacterial infection. Eryth-rocyte sedimentation rates, fibrinogen levels, plasma viscosity, hematocrit, white blood cell count and filterability rates (through 5 μ diameter pore filters, using a low shear positive pressure Nuclepore filtration system) of red blood cells and unfractionated leucocytes were determined at the onset of acute bacterial infection, after 3 weeks at full clinical recovery, and again 2 weeks later at the end of convalescence. Our data confirm that rheological impairments exist at the onset of bacterial infection, and persist up to clinical recovery. At the end of convalescence the unfractioned leucocyte filterability rate was still significantly higher in the elderly patients, compared not only to our normal standard, but also to average values in the younger group. (Aging 3: 57-62, 1991)
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Puniyani R.R., Agashe V.S., Annapurna V., Daga S.R.: Hemorheological profile in cases of chronic infections. Clin. Hemorheol 8: 595–602, 1988.
Harkness j.: The viscosity of human blood plasma; its measurement in health and disease. Biorheology 8: 171–193,1971.
Lowe G.D.O.: Blood rheology in vitro and in vivo. Bailliere’s Clin. Hematol. 1: 597–563, 1987.
Lowe G.D.O.: Blood rheology in general medicine and surgery. Bailliere’s Clin. Hematol 1: 827–861, 1987.
Stuart J, Lewis S.M.: Monitoring the acute phase response. Br. Med. J. 297: 1143–1144, 1988.
Dinarieilo C.: The acute phase response; Root R.K.: The compromised host. In: Wyngaarden J.B., Lloyd H., Smith J.R. (Eds.), Cecil. Textbook of Medicine, ed. 18. WB Sounders Company, Philadelphia, 1988, Chaps. 257, 258, pp. 1527–1538.
Ciuffetti G., Mercuri M., Lombardini R., Paltriccia R., Ott C.: Human leucocyte rheology after acute infection. Haematologica 75: 94–95, 1990.
Mancini G., Carbonara A.D., Haremans J.F.: Immunochemical quantification of antigens by single radial immunodiffusion. Immunochemistry 2: 235–240, 1965.
Mikita J., Nash G.B., Dormandy J.: A simple method of preparing white blood cells for filterability testing. Clin. Hemorheol. 6: 635–639, 1986.
Lennie S.E., Lowe G.D.O., Barbenel J.C., Forbes C.D., Foulds W.S.: Filterability of white blood cell subpopulations, separated by an improved method. Clin. Hemorheol. 7: 811–816, 1987.
Nash G.B., Jones J.G., Mikita J., Christopher B., Dormandy J.A.: Effects of preparative procedures and of cell activation on flow of white cells through micropore filters. Er. J. Haematol. 70: 171–176, 1988.
Ciuffetti G., Balendra R., Lennie S.E., Anderson J., Lowe G.D.O.: Impaired filterability of white cells in acute cerebral infarction. Er. Med. J. 298: 930–931, 1989.
Syrjanen J., Valtonen V.V., Iivanainen N., Kaste M., Huttunen J.K.: Preceding infection as an important risk factor for ischaemic brain infarction in young and middle aged patients. Er. Med. J. 296: 1156–1160, 1988.
Röwlatt C., Franks L.M.; Aging in tissues and cells. In: Brocklehurst J.C. (Ed.), Textbook of Geriatric Medicine and Gerontology. Churchill Livingstone, Edinburgh, 1987, pp. 3–13.
Ernst E., Hammerschmidt D.E., Bagge U., Matrai A., Dormandy J.: Leucocytes and the risk of ischaemic disease. JAMA 257: 2318–2324, 1987.
Nash G.B., Thomas P.R.S., Dormandy J.A.: Abnormal flow properties of white blood cells in patients with severe ischaemia of the leg. Br. Med. J. 296: 1699–1701, 1988.
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Ciuffetti, G., Mercuri, M., Lombardini, R. et al. Blood rheology during bacterial infection in the elderly and early middle-aged. Aging Clin Exp Res 3, 57–62 (1991). https://doi.org/10.1007/BF03323979
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DOI: https://doi.org/10.1007/BF03323979