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Ventricular function in the elderly

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References

  1. Gerstenblith G., Lakatta E.G., Weisfeldt M.L.: Age changes in myocardial function and exercise response. Prog. Cardiovasc. Dis. 19: 1–21, 1976.

    Article  PubMed  CAS  Google Scholar 

  2. Harman D.: The aging process. Proc. Natl. Acad. Sci. USA 78: 7124–7160, 1981.

    Article  PubMed  CAS  Google Scholar 

  3. Raven P.B., Mitchell J.: The effect of aging on the cardiovascular response to dynamic and static exercise. In: Weisfeldt M.L. (Ed.), Aging Series Vol. 12, The Aging Heart: its function and response to stress. Raven Press, New York, 1980, pp, 269–296.

    Google Scholar 

  4. Port S., Cobb F.R., Coleman E., Jones R.: Effect of age on the response of the left ventricular ejection fraction to exercise. N. Engl. J. Med. 303: 1133–1137, 1980.

    Article  PubMed  CAS  Google Scholar 

  5. Kennedy R.D., Andrews G.R., Caird F.I.: Ischemic heart disease in the elderly. Br. Heart J. 39: 1121–1127, 1977.

    Article  PubMed  CAS  Google Scholar 

  6. White N.K., Ewards J.E., Dry T.J.: The relationship of the degree of coronary atherosclerosis with age. Circulation 1: 645–654, 1950.

    Article  Google Scholar 

  7. Gerstenblith G., Fleg J.L., Vahtosh A., Becker L., Kallman C., Andres R., Weisfeldt M.L., Lakatta E.G.: Stress testing redefines the prevalence of coronary artery disease in epidemiologic studies (abstract). Circulation 62: 308, 1980.

    Google Scholar 

  8. Saltin B., Blomqvist G., Mitchell J.H., Johnson R.L. Jr, Wildenthal K., Chapman C.B.: Response to exercise after bed rest and after training. A longitudinal study of adaptive changes in oxygen transport and body composition. Circulation 38 (Suppl. 7): VII–1–78, 1968.

    Google Scholar 

  9. Lakatta E.G., Yin F.C.P.: Myocardial aging: functional alterations and related cellular mechanisms. Am. J. Physiol. 242: H927–941, 1982.

    PubMed  CAS  Google Scholar 

  10. Anversa P., Puntillo E., Nikitin P., Olivetti G., Capasso J.M., Sonnenblick E.H.: Effects of age on mechanical and structural properties of myocardium of Fisher 344 rats. Am. J. Physiol. 256: H1440–1449, 1989.

    PubMed  CAS  Google Scholar 

  11. Wei J.Y., Spurgeon H.A., Lakatta E.G.: Excitation-contraction in rat myocardium. Alterations with adult aging. Am. J. Physiol. 246: H784–H791, 1984.

    PubMed  CAS  Google Scholar 

  12. Lakatta E.G., Gerstenblith G., Angell C.S., Shock N.W., Weisfeldt M.L.: Prolonged contraction duration in aged myocardium. J. Clin. Invest. 55: 61–68, 1975.

    Article  PubMed  CAS  Google Scholar 

  13. Fabiato A.: Calcium release in skinned cardiac cells: variations with species, tissues, and development. Fed. Proc. 41: 2238–2249, 1982.

    PubMed  CAS  Google Scholar 

  14. Bhatnagar G.M., Walford G.D., Beard E.S., Humphreys S.H., Lakatta E.G.: ATPase activity and force production in myofibrils and twitch characteristics in intact muscle from neonatal, adult and senescent rat myocardium. J. Mol. Cell. Cardiol. 16: 203–211, 1984.

    Article  PubMed  CAS  Google Scholar 

  15. Gerstenblith G., Spurgeon J.P., Froehlich J.P., Weisfeldt M.L., Lakatta E.G.: Diminished inotropic responsiveness to ouabain in aged rat myocardium. Circ. Res. 44: 517–523, 1979.

    Article  PubMed  CAS  Google Scholar 

  16. Lakatta E.G., Gerstenblith G., Angell C.S., Shock N.W., Weisfeldt M.L.: Diminished inotropic response of aged myocardium to catecholamines. Circ. Res. 36: 262–269, 1975.

    Article  PubMed  CAS  Google Scholar 

  17. Avolio A.P., Chen S., Wang R.P., Zhang C.L., Li M.F., O’Rourke M.F.: Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation 68: 50–58, 1983.

    Article  PubMed  CAS  Google Scholar 

  18. Linzbach A.J., Akuamoa-Boateng E.: Dis alernsuer-sanderungen des wenschlichen berzens. Das berz-genwicht in alter. Klin. Wochenschr. 51: 156463, 1973.

    Google Scholar 

  19. Unverferth D.V., Fetter J.K., Unverferth B.J., Leier C.V., Magorien R.D., Arn A., Baker P.B.: Human myocardial histologie characteristics in congestive heart failure. Circulation 68: 1194–1200, 1983.

    Article  PubMed  CAS  Google Scholar 

  20. Sjogren A.L.: Left ventricular wall thickness in patients with circulatory overload of the left ventricle. Ann. Clin. Res. 4: 310–318, 1972.

    PubMed  CAS  Google Scholar 

  21. Gerstenblith G., Fredderiksen J., Yin F.C.P., Fortuin N.J., Lakatta E.G., Weisfeldt M.L.: Echocardiographic assessment of a normal adult aging population. Circulation 56: 273–278, 1977.

    Article  PubMed  CAS  Google Scholar 

  22. Fleg J.L., Kennedy H.L.: Cardiac arrhythmias in a healthy elderly population. Detection by 24-hour ambulatory electrocardiography. Chest 81: 302–307, 1982.

    Article  PubMed  CAS  Google Scholar 

  23. Levy D., Savage D.D., Garrison R.J., Balkus A., Anderson K.M., Kannel W.B., Catelli W.P.: The association of left ventricular hypertrophy and ventricular arrhythmias, the Framingham heart study. Circulation 72: (Suppl. Ill) 72,1985 (abstract).

    Google Scholar 

  24. Ferrara N., Furgi G., Coltorti F., Nicolino A., Rossi M., Guerra N., Canonico V., Abete P., Rengo F.: Relationship among age, left ventricular mass and ventricular arrhythmias in hypertension. XIV International Congress of Gerontology, Acapulco, June 18–23, 1989 (abstract).

  25. Lakatta E.G.: Do hypertension and aging similary affect the myocardium? Circulation 75 (Suppl. I): 69–77, 1987.

    Google Scholar 

  26. Spurgeon H.A., Steinbach M.F., Lakatta E.G.: Chronic exercise prevents characteristic age-related changes in rat cardiac contractions. Am. J. Physiol. 244: H513–518, 1983.

    PubMed  CAS  Google Scholar 

  27. Brandfonbrener M., Landowne M., Shock N.W.: Changes in cardiac output with age. Circulation 12: 557–566, 1955.

    Article  PubMed  CAS  Google Scholar 

  28. Strandell T.: Circulatory studies on healthy old men. Acta Med. Scand. 176: 205–218, 1964.

    Article  PubMed  CAS  Google Scholar 

  29. Julius S., Avery A., Whitlock L.S., Conway J.: Influence of age on the hemodynamic response to exercise. Circulation 36: 222–230, 1967.

    Article  PubMed  CAS  Google Scholar 

  30. Conway J., Wheeler R., Hammerstedt R.: Sympathetic nervous activity during exercise in relation to age. Cardiovasc. Res. 5: 577–581, 1971.

    Article  PubMed  CAS  Google Scholar 

  31. Rodeheffer R.J., Gerstenblith G., Becker L.C., Fleg J.L., Weifeidt M.L., Lakatta E.G.: Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate. Circulation 69: 203–213, 1984.

    Article  PubMed  CAS  Google Scholar 

  32. Gardin J.M., Henry W.L., Savage D.D., Ware J.H., Burn C., Borer J.S.: Echocardiographic measurements in normal subjects: evaluation of an adult population without clinically apparent heart disease. J. Clin. Ultrasound 7: 439–447, 1979.

    Article  PubMed  CAS  Google Scholar 

  33. Miyatake K., Okamoto J., Kimoshita N., Owa M., Nakasawe I., Sokakivara H., Nimura Y.: Augmentation of atrial contribution to left ventricular flow with aging as assessed by intracardial doppler flowmetry. Am. J. Cardiol. 53: 586–589, 1984.

    Article  PubMed  CAS  Google Scholar 

  34. Nicolino A., Zoccofillo N., Coltorti F., Furgi G., Guerra N., Rossi M., Longobardi G., Ferrara N., Rengo F.: Influenza dell’età sulla funzione diastolica ventricolare sinistra nei soggetti normali. XLIX Congr. Naz. Soc. It. Cardiol., Roma. 13–16 Dicembre 1988 (abstract).

  35. Bonow R.O., Vitale D., Bacharach S.L., Maron B.J., Green M.V.: Effects of aging on asynchronous left ventricular filling in normal human subjects. J. Am. Coll. Cardiol. 11: 50–58, 1988.

    Article  PubMed  CAS  Google Scholar 

  36. Myreng Y., Nitter-Hauge S.: Age-dependency of left ventricular filling dynamics and relaxation as assessed by pulsed Doppler echocardiography. Clin. Physiol. 9: 99–106, 1989.

    Article  PubMed  CAS  Google Scholar 

  37. Spirito P., Maron B.J.: Influence of aging on Doppler echocardiographic indices of left ventricular diastolic function. Br. Heart J. 59: 672–679, 1988.

    Article  PubMed  CAS  Google Scholar 

  38. Ferrara N., Leosco D., Abete P., Longobardi G., Ilardi C., De Caprio L., Vigorito C., Rengo F.: Use of isometric exercise in diagnosis of critical coronary artery stenosis: a two-dimensional echocardiographic study. J. Cardiovasc. Ultrason. 6: 207–211, 1987.

    Google Scholar 

  39. Ferrara N., Vigorito C., Leosco D., Giordano A., Abete P., Longobardi G., Rengo F.: Regional left ventricular mechanical function during isometric exercise in patients with coronary artery disease: correlation with regional coronary blood flow changes. J. Am. Coll. Cardiol. 12: 1215–1221, 1988.

    Article  PubMed  CAS  Google Scholar 

  40. Mitamura H., Ogawa S., Hori S., Yamazaki H., Handa S., Nakamura Y.: Two-dimensional echocardiographic analysis of wall motion abnormalities during handgrip exercise in patients with coronary artery disease. Am. J. Cardiol. 48: 711–719, 1981.

    Article  PubMed  CAS  Google Scholar 

  41. Yin F.C.P., Raizes G.S., Guarneri T., Spurgeon H.A., Lakatta E.G., Fortuin N.S., Weisfeldt M.L.: Age-associated decrease in ventricular response to hemodynamic stress during beta-adrenergic blockade. Br. Heart J. 40: 1349–1355, 1978.

    Article  PubMed  CAS  Google Scholar 

  42. Leosco D., Ferrara N., Abete P., Caccese P., Sederino S., Landino P., Rengo F.: Valutazione ecocardiografica della funzione ventricolare sinistra nel soggetto anziano in condizioni basali e di aumentato post-carico. 34° Congresso Nazionale della Società Italiana di Gerontologia e Geriatria, Padova, ottobre 1989 (abstract).

  43. Van Tosh A., Lakatta E.G., Fleg J.L., Weiss J., Kall-man C., Weisfeldt M.L., Gerstenblith G.: Ventricular dimensional changes during submaximal exercise: effects of aging in normal men. Circulation 62: 111–129, 1980.

    Google Scholar 

  44. Granath A., Jonsson B., Strandell T.: Circulation in/ healthy old men studies by right heart catheterization at rest and during exercise in supine and sitting positions. Acta Med. Scand. 176: 425–446, 1964.

    Article  PubMed  CAS  Google Scholar 

  45. Weisfeldt M.L., Wright J.R., Shreiner D.P., Lakatta E.G., Shock N.W.: Coronary flow and oxygen extraction in perfused hearts of senescent male rats. J. Appl. Physiol. 30: 44–49, 1971.

    PubMed  CAS  Google Scholar 

  46. Tomanek R.J.: Coronary vasculature of the aging heart. In: Weisfeldt (Ed.), Aging Series Vol. 12, The Aging Heart: its function and response to stress. Raven Press, New York, 1980, pp. 115–135.

    Google Scholar 

  47. Vigorito C., Giordano A., Casaburi E., Ferraro P., Maurelli B., Rumolo S., Silvestri P., Rengo F.: Coronary vascular reserve in elderly subjects. Bibl. Cardiol. 44: 40–46, 1989.

    PubMed  Google Scholar 

  48. Lakatta E.G.: Alterations in the cardiovascular system that occur in advanced age. Fed. Proc. 38: 163–167, 1979.

    PubMed  CAS  Google Scholar 

  49. Kuramoto K., Watsushita S., Mifrene J., Saka M, Mirakami M.: Electrocardiographic and hemodynamic evaluation of isoproterenol test in elderly subjects. Jpn. Circ. J. 42: 955–960, 1978.

    Article  PubMed  CAS  Google Scholar 

  50. Palmer G.J., Ziegler M.G., Lake C.R.: Response of Norepinephrine and blood pressure to stress increase with age. J. Gerontol 33: 482–487, 1978.

    Article  PubMed  CAS  Google Scholar 

  51. Fleg J.L., Tzankoff S.P., Lakatta E.G.: Age-related augmentation of plasma catecholamines during dynamic exercise in healthy males. J. Appl. Physiol 59: 120–127, 1985.

    Google Scholar 

  52. De Caprio L, Ferro G., Cuomo S., Volpe M., Artiaco D., De Luca N., Ricciardelli B.: QT/QS2 ratio as an index of autonomic tone changes. Am. J. Cardiol 53: 818–822, 1984.

    Article  PubMed  Google Scholar 

  53. De Caprio L, Papa M., Acanfora D., Gallucci F., Cicatiello M., Canonico V., Rengo F.: Effects of aging and beta-adrenergic blockade on QT/QS2 changes induced by isometric exercise. J. Appl Cardiol. 3: 101–109, 1988.

    Google Scholar 

  54. De Caprio L, Papa M., Acanfora D., Cuomo S. Vigorito C., Canonico V., Gallucci F., Rengo F.: Effect of aging and beta-adrenergic blockade on standing-induced QT/QS2 changes. J. Gerontol 44: M3–7, 1989.

    Article  PubMed  Google Scholar 

  55. Renlund D., Gerstenblith G., Rodeheffer R.J., Fleg J.L., Lakatta E.G.: Potency of the Frank Starling reserve in normal man. J. Am. Coll Cardiol 5: 514–518, 1985.

    Google Scholar 

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Authors and Affiliations

  1. Istituto di Medicina Interna, Cardiologia e Chirurgia Cardiovascolare, Cattedra di Geriatria, II Facoltà di Medicina e Chirurgia di Napoli, Via Sergio Pansini 5, 80131, Napoli, Italy

    Franco Rengo & D. Leosco

  2. Fondazione Clinica del Lavoro, Centro Medico di Campoli MT (IRCCS), Benevento, Italy

    N. Ferrara

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  1. Franco Rengo
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  2. N. Ferrara
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  3. D. Leosco
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Rengo, F., Ferrara, N. & Leosco, D. Ventricular function in the elderly. Aging Clin Exp Res 3, 9–17 (1991). https://doi.org/10.1007/BF03323966

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