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Cross-sectional microhardness of bovine enamel subjected to three paediatric liquid oral medicines: an in vitro study

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Abstract

AIM: This study aimed to investigate the in vitro effects of three paediatric liquid oral medicines on bovine dental enamel subsurfaces under pH cycling conditions. METHODS: Bovine enamel blocks were evaluated for surface hardness at baseline for sample selection. 52 intact bovine enamel blocks (16mm2) were randomly divided into four groups (n=13) according to the immersion treatments: G1: antibiotic (Klaricid®), G2: antihistamine (Claritin®), G3: antihistamine (Dimetapp®) and G4: control (de-ionised water). The blocks were submitted to pH cycling treatments twice a day for 12 days. The medicines were evaluated for pH, viscosity, and concentration of calcium, phosphate and fluoride. After the treatment period, cross-sectional microhardness (CSMH) measurements of the enamel blocks were taken and the data, expressed in Knoop hardness number (kg/mm2) was used to calculate the ΔS. STATISTICS: ANOVA followed by the Tukey test were used for statistical analyses (p<0.05). RESULTS: The antibiotic Klaricid® showed the highest concentration of fluoride, calcium and phosphate. Considering pH and viscosity, the following pattern was observed according to the treatment group: G4>G1>G2>G3 and G1>G2>G3>G4 respectively. Regarding the demineralisation pattern, the following results were observed: G4>G3>G2>G1. Compared to the control, the antibiotic and both the anti-histamines provoked less demineralisation of the enamel blocks (p<0.05). CONCLUSIONS: Antibiotic G1 (Klaricid ®sented an in vitro protective effect against acid attacks probably due to its mineral content and viscosity.

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Authors and Affiliations

  1. Department of Paediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Cidade Universitária — CCS, Caixa Postal 68066, Rio de Janeiro, Brazil

    D. N. Soares, A. C. Valinoti, A. G. Antonio &  L. C. Maia

  2. Department of Paediatric Dentistry, School of Dentistry, Universidade Salgado de Oliveira, Brazil

    V. S. S. Pierro

  3. Department of PostGraduation, School of Dentistry, Universidade Veiga de Almeida, Brazil

    A. G. Antonio

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  1. D. N. Soares
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  2. A. C. Valinoti
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  3. V. S. S. Pierro
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  4. A. G. Antonio
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  5. L. C. Maia
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Correspondence to L. C. Maia.

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Soares, D.N., Valinoti, A.C., Pierro, V.S.S. et al. Cross-sectional microhardness of bovine enamel subjected to three paediatric liquid oral medicines: an in vitro study. Eur Arch Paediatr Dent 13, 261–265 (2012). https://doi.org/10.1007/BF03262882

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