European Archives of Paediatric Dentistry

, Volume 9, Issue 4, pp 166–171 | Cite as

Nothing new under the heavens: MIH in the past?

  • A. R. OgdenEmail author
  • R. Pinhasi
  • W. J. White


Aim: This was to study an archaeological population of sub-adult teeth in 17th and 18th century skeletal material from a London (England) cemetery for enamel defects including molar-incisor-hypomineralisation (MIH). Methods: Dentitions of 45 sub-adults were examined using standard macroscopic methods and systematically recorded. A total of 557 teeth were examined with a *5 lens and photographed. Ages of the individuals were estimated from their dental crown and root development stages and not from charts that combine tooth eruption with development stages. The dental age of the individual and the approximate age of onset of enamel defects was then calculated on the basis of the chronological sequence of incremental deposition and calcification of the enamel matrix. Affected enamel was graded macroscopically as: — Mild: <30% of the tooth’s enamel surface area visibly disrupted (this encompasses the entire range reported in most other studies), Moderate: 31–49% of the tooth’s enamel surface area visibly disrupted and Severe: >50% of the tooth’s enamel surface area visibly disrupted. Results: Of the total number of individuals 41 (93.2%) showed signs of enamel developmental dysplasia or MIH, 28 of them showing moderate or severe lesions of molars, primary or permanent (63.6% of the sample). Incisors and canines, though surviving much less often, showed episodes of linear hypoplasia. Conclusion: The extensive lesions seen on many of the molars displayed cuspal enamel hypoplasia (CEH). Many of these teeth also exhibited Molar Incisal Hypomineralisation (MIH).

Key words

molar-incisor-hypomineralisation archaeology 


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  1. Alaluusua S, Lukinmaa PL, Koskimies M, et al. Developmental dental defects associated with long breastfeeding. Eur J Oral Sci 1996;104:493–7.PubMedCrossRefGoogle Scholar
  2. Alvarez JA. Nutrition, tooth development, and dental caries. Am J Clin Nutr 1995;61 supp: 410S–416S.PubMedGoogle Scholar
  3. Beentjes VE, Weerheim KL, Groen HJ. Factors involved in the aetiology of molar-incisor hypomineralisation (MIH). Eur J Paediatr Dent 2003;3: 9–13.Google Scholar
  4. Bogin B. Social and economic class. In: Ulijaszek, SJ, Johnston, FE, Preece, MA, editors. The Cambridge encyclopaedia of human growth and development. Cambridge, Cambridge University Press. 1998. p 399–401.Google Scholar
  5. David, L. Common Vitamin D-Deficiency Rickets. In: Glorieux FH. editor. Rickets. Nestlé Nutrition Workshop Series, Vol 21. New York: Raven Press. 1991. p 107–122.Google Scholar
  6. Dummer PM, Kingdon A, Kingdon R. Distribution of developmental defects of tooth enamel by tooth type in 11–12 year-old children in South Wales. Comm Dent Oral Epidemiol 1986;14: 341–344.CrossRefGoogle Scholar
  7. Ensor BE, Irish JD. Hypoplastic area method for analysing dental enamel hypoplasia. Am J Phys Anthropol 1995;98: 507–517.PubMedCrossRefGoogle Scholar
  8. Fagrell GF, Lingstrom P, Olsson S, Steininger F, Noren, JG. Bacterial invasion of dentinal tubules beneath apparently intact but hypomineralised enamel in molar teeth with molar-incisor-hypomineralisation. Int J Paediatr Dent 2008;18: 333–340.PubMedCrossRefGoogle Scholar
  9. Fédération Dentaire International. 1 A review of the developmental defects of enamel index (DDE Index). Commission on Oral Health, Research & Epidemiology: Report of an FDI Working Group. Int Dent J 1992;42: 411–26.Google Scholar
  10. Finlay R. Population and metropolis: the demography of London 1580–1650. Cambridge: Cambridge University Press. 1981.CrossRefGoogle Scholar
  11. FitzGerald CM. Do enamel microstructures have regular time dependency? Conclusions from the literature and a large-scale study. J Hum Evol 1998;35:371–86.PubMedCrossRefGoogle Scholar
  12. Floud R., Wachter K. Poverty and physical stature: evidence on the standard of living in London boys, 1770–1870. Soc Sci Hist 1982;6: 422–452.CrossRefGoogle Scholar
  13. Gautelli-Steinberg D, Lukacs JR. Interpreting sex differences in enamel hypoplasia in human and non-human primates: Developmental, environmental, and cultural considerations. Yrbk Phys Anthropol 1999;42: 78–126.Google Scholar
  14. Goodman AH, Rose JC. Assessment of systemic physiological perturbations from dental enamel hypoplasias and associated histological structures. Yrbk Phys Anthropol 1990;33: 59–110.CrossRefGoogle Scholar
  15. Harding V. The dead and the living in Paris and London 1500–1670. Cambridge: Cambridge University Press., 2002.Google Scholar
  16. Hargreaves JA, Cleaton-Jones PE, Williams SD. Hypocalcification and hypoplasia in permanent teeth of children from different ethnic groups in South Africa assessed with a new index. Adv Dent Res 1989;3:126–31.PubMedGoogle Scholar
  17. Hillson S. Studies of growth in dental tissues. In: Lukacs, JR, editor. Culture, Ecology and Dental Anthropology. Journal of Human Ecology, Special Issue 2. Delhi, Kamla-Ray Enterprises, 1992, pp. 7–23.Google Scholar
  18. Hillson S. Teeth. 2nd edition. Cambridge: Cambridge University Press. 2005., p 169–176.CrossRefGoogle Scholar
  19. Hillson S, Bond S. Relationship of enamel hypoplasia to the pattern of tooth crown growth: A discussion. Am J Phys Anthropol 1997;104:89–103.PubMedCrossRefGoogle Scholar
  20. Hillson S, Grigson C, Bond S. Dental defects of congenital syphilis. Am J Phys Anthropol 1998;107: 25–40.PubMedCrossRefGoogle Scholar
  21. Inwood S. A history of London.: Macmillan, London., 1998.Google Scholar
  22. Jälevik B, and Norén JG. Enamel hypomineralisation of permanent first molars: a morphological study and survey of possible aetiological factors. Int J Paediatr Dent 2000;10:278–89.PubMedCrossRefGoogle Scholar
  23. Jälevik B, Klingberg G, Barregard L, Norén JG. The prevalence of demarcated opacities in permanent first molars in a group of Swedish children. Acta Odontol Scand 2001;59:255–60.PubMedCrossRefGoogle Scholar
  24. Jälevik B, Dietz W, Norén JG. Scanning electron micrograph analysis of hypomineralised enamel in permanent first molars. Int J Paediatr Dent 2002;15: 233–240.CrossRefGoogle Scholar
  25. Jenkins GN. The physiology and biochemistry of the mouth. Oxford, Blackwell., 1978.Google Scholar
  26. King T, Humphrey LT, Hillson S. Linear enamel hypoplasias as indicators of systemic physiological stress: evidence from two known age-at-death and sex populations from postmedieval London. Am J Phys Anthropol 2005;128:547–59.PubMedCrossRefGoogle Scholar
  27. Kunzel W. Hypomineralisation of molars and incisors. (German) Zahnärztl Mitt 2003;93:1626–9.Google Scholar
  28. Larsen CS. Bioarchaeological interpretations of subsistence economy and behavior from human skeletal remains. Adv Archaeol Method Theory 1987;10:339–445.Google Scholar
  29. Lewis ME. The impact of industrialisation: comparative study of child health in four sites from medieval and post-medieval England (850-1859). Am J Phys Anthropol 2002a;119, 211–223.PubMedCrossRefGoogle Scholar
  30. Lewis ME. Urbanisation and Child Health in Medieval and Post-Medieval England. BAR British Series 339, BAR: Oxford., 2002bGoogle Scholar
  31. Mays S. The rise and fall of rickets in England. In: The environmental archaeology of industry. Murphy P, Wiltshire PEJ, editors. Oxford: Oxbow. 2003. p 144–153Google Scholar
  32. Mays S, Brickley M, Ives R. Skeletal Manifestations of Rickets in Infants and Young Children in an Historic Population from England. Am J Phys Anthropol 2006;129:518–528.PubMedCrossRefGoogle Scholar
  33. Moorrees CFA, Fanning EA, Hunt EE. Age variation of formation stages for ten permanent teeth. J Dent Res 1963a;42,1490–1502.PubMedCrossRefGoogle Scholar
  34. Moorrees CFA, Fanning EA, Hunt EE. Formation and resorption of three deciduous teeth in children. Am J Phys Anthropol 1963b;21, 205–213.PubMedCrossRefGoogle Scholar
  35. Ogden A. R., Pinhasi R, White WJ. Severe Dental Enamel Hypoplasia of molars in subadultsfroma 16th–18th Century London graveyard. Amer J Physic Anthropol 2007;133: 957–966.CrossRefGoogle Scholar
  36. Palumbeckaite Z, Jankausas R, Boldsen J. Enamel hypoplasia in Danish and Lithuanian Late Medieval/early modern samples: A possible reflection of child morbidity and mortality patterns. Int J Osteoarch 2002;12:189–201.CrossRefGoogle Scholar
  37. Pinhasi R, Shaw P, White B, Ogden AR. Morbidity, rickets, and long-bone growth in post-medieval Britain — a cross-population analysis. Ann Hum Biol 2006;33: 372–389.PubMedCrossRefGoogle Scholar
  38. Psoter WJ, Reid BC, Katz RV. Malnutrition and dental caries: a review of the literature. Caries Res 2005;39:441–7.PubMedCrossRefGoogle Scholar
  39. Purvis RJ, Barrie WJ, MacKay GS, et al. Enamel hypoplasia of the teeth associated with neonatal tetany: a manifestation of maternal vitamin-D deficiency. Lancet 1973;2:811–4.PubMedCrossRefGoogle Scholar
  40. Reid DJ, Dean MC. Variation in modern human enamel formation times. J Hum Evol 2006;50:329–46.PubMedCrossRefGoogle Scholar
  41. Saunders SR, Hoppa RD, Macchiarelli R, Bondioli L. Investigating variability in human dental development in the past. Anthropologie 2000;38,101–107.Google Scholar
  42. Seow WK, Young WG, Tsang AK, Daley T. A study of primary dental enamel from preterm and full-term children using light and scanning electron microscopy. Pediatr Dent 2005;27:374–9.PubMedGoogle Scholar
  43. Skinner M, Goodman AH. Anthropological uses of developmental defects in enamel. In: Saunders SR, Katzenberg MA, editors. Skeletal biology of past people: research methods. New York: Wiley-Liss. 1992., pp 153–174.Google Scholar
  44. Smith BH. Standards of human tooth formation and dental age assessment. In: Kelley MA, Larsen CS, editors. Advances in dental anthropology. New York: Wiley-Liss. 1991., pp 143–168.Google Scholar
  45. Stuart-Macadam PL. Nutritional Deficiency Diseases: A survey of scurvy, rickets, and iron-deficiency anaemia. In: Iscan MY, Kennedy KAR, editors. Reconstruction of life from the skeleton. New York: Wiley-Liss. 1989.Google Scholar
  46. Suckling GW. Developmental defects of enamel — historical and present-day perspectives of their pathogenesis. Adv Dent Res 1989;3: 87–94.PubMedGoogle Scholar
  47. Suckling GW, Brown RH, Herbison GP. The prevalence of developmental defects of enamel in 696 nine-year-old New Zealand children participating in a health and development study. Community Dent Health 1985;2:303–13.PubMedGoogle Scholar
  48. Suckling GW, Pearce EI. Developmental defects of enamel in a group of New Zealand children: their prevalence and some associated etiological factors. Community Dent Oral Epidemiol 1984;12:177–84.PubMedCrossRefGoogle Scholar
  49. Suga S. Enamel hypomineralisation viewed from the pattern of progressive mineralisation of human and monkey developing enamel. Adv Dent Res 1989;3: 188–198.PubMedGoogle Scholar
  50. Ubelaker DH. Human skeletal remains. 2nd edn. Washington: Taraxacum Press., 1989.Google Scholar
  51. van Amerongen WE, Kreulen CM. Cheese molars: a pilot study of the etiology of hypocalcifications in first permanent molars. ASDC J Dent Child 1995;62:266–9.PubMedGoogle Scholar
  52. Weerheijm KL. Molar-incisor-hypomineralisation (MIH). Eur J Paediatr Dent 2003;4:114–20.PubMedGoogle Scholar
  53. Weerheijm KL, Duggal M, Mejare I, et al. Judgement criteria for molar-incisor-hypomineralisation MIH in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur J Paediatr Dent 2003;4:110–3.PubMedGoogle Scholar
  54. Welch TR, Bergstrom WH, Tsang RC. Vitamin D-deficient rickets: the re-emergence of a once conquered-disease. J Paediatr 2000;137:143–5.CrossRefGoogle Scholar
  55. Wharton B, Bishop N. Rickets. Lancet 2003;362,1389–1400.PubMedCrossRefGoogle Scholar
  56. White WJ. The human skeletal remains from the Broadgate site LSS85. Museum of London Archaeological Service MOLAS unpublished report. 1987. HUM/REP/87/01Google Scholar

Copyright information

© Adis International 2008

Authors and Affiliations

  1. 1.Biological Anthropology Research Centre (BARC), Archaeological SciencesUniversity of BradfordBradfordEngland
  2. 2.Dept. ArchaeologyUniversity of CorkIreland
  3. 3.Centre for Human BioarchaeologyMuseum of LondonLondonEngland

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