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Gastrointestinal Mucosal Lesions

A Drug Formulation Problem

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References

  • Alsop WR, Moore JB, Rollins DE, Tolman KG. The effects of five potassium chloride preparations on the upper gastrointestinal mucosa in healthy subjects receiving glycopyrrolate. Journal of Clinical Pharmacology 24: 235–239, 1984

    PubMed  CAS  Google Scholar 

  • Atkins EL, Schwartz WB. Factors governing correction of the alkalosis associated with potassium deficiency; the critical role of chloride in the recovery process. Journal of Clinical Investigation 41: 218–229, 1962

    Article  PubMed  CAS  Google Scholar 

  • Barkin JS, Harary AM, Shamlen CE, Lasseter KD. Potassium chloride and gastrointestinal injury. Annals of Internal Medicine 98: 261–262, 1983

    PubMed  CAS  Google Scholar 

  • Baskin WN, Ivey KJ, Krause WF, Jeffrey GE, Gemmell RT. Aspirin-induced ultrastructural changes in human gastric mucosa. Annals of Internal Medicine 85: 299–303, 1976

    PubMed  CAS  Google Scholar 

  • Bobrove AM, Calin A. Efficacy and tolerance of a novel precision-dose formulation of indomethacin: double-blind trials in rheumatoid arthritis and osteoarthritis. Current Medical Research and Opinion 8 (Suppl. 2): 55–61, 1983

    Article  PubMed  Google Scholar 

  • Börsch G, Schmidt G. Arzneimittelschäden in obern Magen-Darm-Trakt. Medizinische Monatschrift der Pharmacie 7: 227–232, 1984

    Google Scholar 

  • Carlborg B. Complications when drugs accidentally dissolve in the oesophagus and the airways. Läkertidningen 73: 4201–4204, 1976

    CAS  Google Scholar 

  • Carlborg B, Densert O. Esophageal lesions caused by orally administered drugs: an experimental study in the cat. European Surgical Research 12: 270–282, 1980a

    Article  PubMed  CAS  Google Scholar 

  • Carlborg B, Densert O. Speiseröhren-komplikationen — Doxycyclin Zubereitungen im vergleichenden Test. Eine Tierexperimentelle Studie. Arznei-Telegramm 8: 64–67, 1980b

    Google Scholar 

  • Carlborg B, Densert O, Lindqvist C. Tetracycline induced esophageal ulcers: a clinical and experimental study. Laryngoscope 93: 184–187, 1983

    PubMed  CAS  Google Scholar 

  • Carlborg B, Farmer JC. Esophagal corrosion tests with doxycycline monohydrate tablets. Current Therapeutic Research 34: 110–116, 1983

    Google Scholar 

  • Carlborg B, Kumlien A, Olsson H. Oesophageal strictures induced by oral drug therapy. Läkartidningen 75: 4609–4622, 1978

    PubMed  CAS  Google Scholar 

  • Caruso I, Bianchi Porro G. Gastroscopic evaluation of antiinflammatory agents. British Medical Journal 280: 75–78, 1980

    Article  PubMed  CAS  Google Scholar 

  • Channer KS, Virjee J. Effects of posture and drink volume on the swallowing of capsules. British Medical Journal 285: 1702, 1982

    Article  PubMed  CAS  Google Scholar 

  • D’Arcy PF. Oesophageal problems with tablets and capsules. Pharmacy International 5: 109, 1984

    Google Scholar 

  • Day TK. Intestinal perforation associated with osmotic slow release indomethacin capsules. British Medical Journal 287: 1671–1672, 1983

    Article  PubMed  CAS  Google Scholar 

  • Djupesland G, Rolstad EA. Etsskader i oesophagus forarsaket av medikamenter. Tidsskrift for Den norske Laegeforening 98: 696–697; 1978

    PubMed  CAS  Google Scholar 

  • Douthwaite AH, Lintott GAM. Gastroscopic observation of the effect of aspirin and certain other substances on the stomach. Lancet 2: 1222–1225, 1938

    Article  Google Scholar 

  • Dybdahl JH, Daae LNW, Larsen S, Ekeli H, et al. Acetylsalicylic acid-induced gastrointestinal bleeding determined by 51Cr method on a day-to-day basis. Scandinavian Journal of Gastroenterology 15: 887–895, 1980

    Article  PubMed  CAS  Google Scholar 

  • General Practitioner Research Group. An alkaline phenylbutazone preparation. Practitioner 203: 357–360, 1969

    Google Scholar 

  • Graham DY, Smith L, Holmes GI, Davies RO. Nonsteroidal antiinflammatory effect of sulindac sulfoxide and sulfide on gastric mucosa. Clinical Pharmacology and Therapeutics 38: 65–70, 1985

    Article  PubMed  CAS  Google Scholar 

  • Hansen TM, Matzen P, Madsen P. Edoscopic evaluation of the effect of indomethacin capsules and suppositories on the gastric mucosa in rheumatic patients. Journal of Rheumatology 11: 484–487, 1984

    PubMed  CAS  Google Scholar 

  • Hart CB, Rhymer AR, Miola SR. Indocin® SR (Indomethacin, MSD) in the treatment of moderate to severe rheumatoid arthritis. Seminars in Arthritis and Rheumatism 12 (Suppl. 1): 147–151, 1982

    Article  Google Scholar 

  • Hart CB, Tempero KF, Sromovsky JA, Rhymer AR. ‘Osmosin’ (sodium indomethacin trihydrate) in the treatment of elderly patients with osteoarthritis. Current Medical Research and Opinion 8 (Suppl. 2): 72–82, 1983

    Article  PubMed  Google Scholar 

  • Haxholdt H, Hey H, Lech Y, Matzen P. Endoscopic comparison of the effect on the gastric mucosa of two formulations of potassium chloride and placebo. Current Therapeutic Research, in press, 1987

  • Hey H, Jorgensen F, Sorensen K, Hasselbach H, Wamberg T. Oesophageal transit of six commonly used tablets and capsules. British Medical Journal 285: 1717–1719, 1982

    Article  PubMed  CAS  Google Scholar 

  • Hey H, Wamberg T, Rasmussen M, Jorgensen F. Endoscopic evaluations of potentially ulcerogenic drugs: a new in vivoporcine test model. European Surgical Research, in press, 1986

  • Hoftiezer JW, Silvoso GR, Burks M, Ivey KJ. Comparison of the effects of regular and enteric-coated aspirin on gastroduodenal mucosa of man. Lancet 2: 609–612, 1980

    Article  PubMed  CAS  Google Scholar 

  • Husby G, Holme I, Rugstad HE, Herland OB, Giercksky K-E. A double-blind multi-centre trial of piroxicam and naproxen in osteoarthritis. Clinical Rheumatology 5: 84–91, 1986

    Article  PubMed  CAS  Google Scholar 

  • Ivey KJ, Paone DB, Krause WJ. Acute effect of systemic aspirin on gastric mucosa in man. Digestive Diseases and Sciences 25: 97–99, 1980

    Article  PubMed  CAS  Google Scholar 

  • Johansson H-E, Jönsson M. An animal model for preclinical testing of local irritant effects of drugs on the oesophagus. Scientific report, Kabi-Vitrum AB, Stockholm, 1984

  • Kassirer JP, Berkman PM, Lawrenz DR, Schwartz WB. The critical role of chloride in the correction of hypokalemic alkalosis in man. American Journal of Medicine 38: 172–189, 1965

    Article  PubMed  CAS  Google Scholar 

  • Kendall C, Krantz KD, Berger A, Sharp T. Endoscopic evaluations of slow-release potassium chloride preparations. Clinical Pharmacolgy and Therapeutics 3: 28–30, 1985

    Article  Google Scholar 

  • Kilander A, Dotevall G. Endoscopic evaluation of the comparative effects of acetylsalicylic acid and choline magnesium trisalicylate on human gastric and duodenal mucosa. British Journal of Rheumatology 22: 36–40, 1983

    Article  PubMed  CAS  Google Scholar 

  • Lanza FL, Nelson RS, Rack MF. A controlled endoscopic study comparing the toxic effects of sulindac, naproxen, aspirin, and placebo on the gastric mucosa of healthy volunteers. Journal of Clinical Pharmacology 24: 89–95, 1984

    PubMed  CAS  Google Scholar 

  • Lanza FL, Rack MF, Wagner GS, Balm TK. Reduction in gastric mucosal hemorrhage and ulceration with chronic high-levels dosing of enteric-coated aspirin granules two and four times a day. Digestive Diseases and Sciences 30: 509–512, 1985

    Article  PubMed  CAS  Google Scholar 

  • Lanza FL, Royer GL, Nelson RS. Endoscopic evaluation of the effects of aspirin, buffered aspirin, and enteric-coated aspirin on gastric and duodenal mucosa. New England Journal of Medicine 303: 136–138, 1980

    Article  PubMed  CAS  Google Scholar 

  • Lanza FL, Royer GL, Nelson RS, Chen TT, Seckman CE, Rack MF. The effects of ibuprofen, indomethacin, aspirin, naproxen and placebo on the gastic mucosa of normal volunteers. Digestive Diseases and Sciences 24: 823–828, 1979

    Article  PubMed  CAS  Google Scholar 

  • Lanza FL, Umbenhauer ER, Nelson RS, Rack MF, Daurio CP, et al. A double-blind randomized placebo controlled gastroscopic study to compare the effects of indomethacin capsules and indomethacin suppositories on the gastric mucosa of human volunteers. Journal of Rheumatology 9: 415–419, 1982

    PubMed  CAS  Google Scholar 

  • Lech Y, Hey H, Matzen P, Ostergaard O. Evaluation of the ulcerogenic effect of potassium choride by endoscopy and fecal blood loss. Journal of Clinical Pharmacology, in press, 1986

  • Leijonmarck C-E, Räf L. Gastrointestinal lesions and potassium chloride supplements. Lancet 1: 56–57, 1985

    Article  PubMed  CAS  Google Scholar 

  • Leitold M, Wildfeuer A. Esophageal corrosion test with doxycycline hyclate and doxycycline monohydrate tablets and capsules in cats. Heinrich Mack NACHF, Illertissen, West Germany, 1984

  • Lind O. Medikamentindusert øsofagitt. Tidsskrift for Den Norske Laegeforening 98: 742, 1978

    PubMed  CAS  Google Scholar 

  • Marvola M, Jajaniemi M, Marttila E, Vahervuo K, Sothmann A. Effect of dosage form and formulation factors on the adherence of drugs to the esophagus. Journal of Pharmaceutical Sciences 72: 1034–1036, 1983

    Article  PubMed  CAS  Google Scholar 

  • McCall AJ. Slow-K ulceration of oesophagus with aneurismal left atrium. British Medical Journal 3: 230–231, 1975

    Article  PubMed  CAS  Google Scholar 

  • McLoughlin JC. Gastrointestinal lesions and potassium chloride supplements. Lancet 1: 581–582, 1985

    Article  Google Scholar 

  • McMahon FG, Ryan JR, Akdamar K, Ertain A. Upper gastrointestinal lesions after potassium chloride supplements: a controlled clinical trial. Lancet 2: 1059–1061, 1982

    Article  PubMed  CAS  Google Scholar 

  • McMahon FG, Ryan JR, Akdamar K, Ertan A. Effect of potassium chloride supplements on upper gastrointestinal mucosa. Clinical Pharmacology and Therapeutics 35: 852–855, 1984

    Article  PubMed  CAS  Google Scholar 

  • Mielants H, Veys EM, Verbruggen G, Schelstraete K. Salicylate-induced occult gastrointestinal blood loss: comparison between different oral and parenteral forms of acetylsalicylates and salicylates. Clinical Rheumatology 3: 47–54, 1984

    Article  PubMed  CAS  Google Scholar 

  • Morris AD, Holt SD, Silvoso GR, Hewitt J, Fatum W, et al. Effect of anti-inflammatory drug administration in patients with rheumatoid arthritis. Scandinavian Journal of Gastroenterology 16 (Suppl. 67): 131–135, 1981

    Google Scholar 

  • Olovson S-G, Havu N, Regardh C-G, Sandberg A. Oesophageal ulceration and plasma levels of different alprenolol salts: potential implications for the clinic. Acta Pharmacologica et Toxicologica 58: 55–60, 1986

    Article  PubMed  CAS  Google Scholar 

  • Olovson S-G, Bjorkman J-A, Ek L, Havn N. The ulcerogenic effect on the oesophagus of three β-adrenoceptor antagonists, investigated in a new porcine oesophagus test model. Acta Pharmacologica et Toxicologica 53: 385–391, 1983

    Article  PubMed  CAS  Google Scholar 

  • Patterson DJ, Weinstain GS, Jeffries GH. Endoscopic comparison of solid and liquid potassium chloride supplements. Lancet 2: 1077–1078, 1983

    Article  PubMed  CAS  Google Scholar 

  • Pemberton J. Oesophageal obstruction and ulceration caused by oral potassium therapy. British Heart Journal 32: 267–268, 1970

    Article  PubMed  CAS  Google Scholar 

  • Rainsford K. Side-effects of anti-inflammatory analgesic drugs: epidemiology and gastrointestinal tract. Trends in Pharmacological Sciences 5: 156–159, 1984

    Article  CAS  Google Scholar 

  • Rainsford KD, Whitehouse MW. Gastric irritancy of aspirin and its congeners: anti-inflammatory activity without this side-effect. Journal of Pharmacy and Pharmacology 28: 599–601, 1976

    Article  PubMed  CAS  Google Scholar 

  • Rhymer AR, Sromovshy JA, Dicenta C, Hart CB. ‘Osmosin’: a multi-centre evaluation of a technological advance in the treatment of osteoarthritis. Current Medical Research and Opinion 8 (Suppl. 2): 62–71, 1983

    Article  PubMed  Google Scholar 

  • Räf LR. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chirugica Scandinavica (Suppl. 374): 1–87, 1967

  • Schiantarelli P, Cadel S, Folco GC. Gastroprotective effects of morniflumate, an esterified anti-inflammatory drug. Arzneimittel-Forschung 34(II): 885–890, 1984

    PubMed  CAS  Google Scholar 

  • Serck-Hanssen A, Daae L. Tynntarmssar hos pasienter behandlet med thiazidpreparater tilsatt kalium. Tidsskrift for Den Norske Laegeforening 85: 1115, 1965

    Google Scholar 

  • Silvoso GR, Ivey KJ, Butt JH, Lockard OO, Holt DS, et al. Incidence of gastric lesions in patients with rheumatic disease on chronic aspirin therapy. Annals of Internal Medicine 91: 517–520, 1979

    PubMed  CAS  Google Scholar 

  • Strouthidis TM, Mankikar GD, Irvine RE. Ulceration of the mouth due to emepronium bromide. Lancet 1: 72–73, 1972

    Article  PubMed  CAS  Google Scholar 

  • Thorsen Jr WB, Western D, Tanaka Y, Morrisey JF. Aspirin injury to the gastric mucosa: gastrocamera observations of the effect of pH. Archives of Internal Medicine 121: 499–506, 1968

    Article  PubMed  Google Scholar 

  • Trondstad RI, Aadland E, Holler T, Olaussen B. Gastroscopic findings after treatment with enteric-coated and plain naproxen tablets in healthy subjects. Scandinavian Journal of Gastroenterology 20: 239–242, 1985

    Article  PubMed  CAS  Google Scholar 

  • Walt R, Katschinski B, Logan R, Ashley J, Langman M. Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet 1: 489–492, 1986

    Article  PubMed  CAS  Google Scholar 

  • Whitney B, Croxon R. Dysphagia caused by cardiac enlargement. Clinical Radiology 23: 147–152, 1972

    Article  PubMed  CAS  Google Scholar 

  • Widman L, Dyckner T, Wester O. Effect of Moduretic and Aldactone on electrolytes in skeletal muscle in patients on long-term diuretic therapy. Acta Medica Scandinavica 212 (Suppl. 661): 33–35, 1982

    Google Scholar 

  • Whitehouse MW, Rainsford KD. Esterification of acidic anti-inflammatory drugs suppresses their gastrotoxicity without adversely affecting their anti-inflammatory activity in rats. Journal of Pharmacy and Pharmacology 32: 795–796, 1980

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Pharmacotherapeutics, University of Oslo, P.O. Box 1065, Blindern, N-0316, Oslo 3, Norway

    Odd Brors

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Brors, O. Gastrointestinal Mucosal Lesions. Drugs 2, 105–111 (1987). https://doi.org/10.1007/BF03260009

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