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An Overview of the Clinical Experience with Secnidazole in Bacterial Vaginosis and Trichomoniasis

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Summary

Treatment of vaginal trichomoniasis and, more recently, bacterial vaginosis with a single dose of secnidazole has not been extensively reported in the literature. The objective of the present study was to review the pertinent literature for an evaluation of the efficacy and tolerability of this drug in the treatment of lower genital tract infections.

A retrospective analysis of the results obtained in a number of studies showed that secnidazole is effective in the treatment of trichomoniasis (a cure rate of 90 to 97%) and of bacterial vaginosis (a cure rate of 85 to 95%), is well tolerated (an 8 to 32% frequency of mild adverse effects), and requires only a single dose therapy.

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References

  1. Bagnoli VR, Pereira AS, Menke CH, et al. Estudo multicêntrico brasileiro dos agentes causadores de vaginites. XVI Congress of Obstetrics and Gynecology of the North and Northeast, Olinda, April 4-7, 1990

    Google Scholar 

  2. Eschenbach DA, Hillier S, Critchlow C, et al. Diagnosis and clinical manifestations of bacterial vaginosis. Am J Obstet Gynecol 1988; 158(4): 819–28

    PubMed  CAS  Google Scholar 

  3. Benazet F, Guillaume L. Activités antiamibienne et trichomonacide du secnidazole au laboratoire. Bull Soc Path Ex 1976; 4: 309–19

    Google Scholar 

  4. Siboulet A, Catalan F, Videau D, et al. La trichomonase urogénitale essais d’un imidazole à demi-vie longue le secnidazole. Med et Malad Inf 1977; 7(9): 400–9

    Article  Google Scholar 

  5. Frydman AM, Lemar M, Le Roux Y, et al. A review of the phannacokinetics of secnidazole in man. In: Katz & Willis, editors. Secnidazole: a new approach in 5-nitroimidazole therapy. Symposium Proceedings, Excerpta Medica, Jerusalem, June 11 to 16, 1989; 12–27

  6. De Meo M, Vanelle P, Bernardini E, et al. Evaluation of the mutagenic and genotoxic activities of 48 nitroimidazoles and related imidazole derivatives by the Ames test and the SOS chromotest. Environ Mol Mutagen 1992; 19(2): 167–81

    Article  PubMed  Google Scholar 

  7. Meingassner JG, Heyworth PG. Intestinal and urogenital flagellates. Antib Chemot 1981; 30: 163–202

    CAS  Google Scholar 

  8. Kent HL. Epidemiology of vaginitis. Am J Obstet Gynecol 1991; 165(4): 1168–76

    PubMed  CAS  Google Scholar 

  9. Orduña Domingo A, Chu JJ, Eiros Bouza JM, et al. Age and sex distribution of sexually transmitted diseases in Valladolid, a study of 5076 cases. Rev Sanid Hig Publica 1991; 65(3): 247–58

    PubMed  Google Scholar 

  10. Alvarez Bravo A, Queiroz Vásquez RQ, Farrugia DL. Tratamiento de la vaginitis par Trichomoniasismonas con secnidazol in dosis única. Invest Med Interna 1978; 5: 476–82

    Google Scholar 

  11. Moldwin RM. Sexually transmitted protozoal infections Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia. Urol Clin North Am 1992; 19(1): 93–101

    PubMed  CAS  Google Scholar 

  12. Piato S, Cymbalista N. Tratamento da tricomoniase com dose única de secnidazol. Rev Bras Med 1977; 34(4): 180–4

    Google Scholar 

  13. Rocha AM, Sarraf Neto A. Tratamento da tricomonfase urogenital. Rev Bras Med 1977; 34(6): 365–6

    Google Scholar 

  14. Machado D, Machado LE. Secnidazol em dose única no tratamento da tricomoníase vaginal comparaçao entre a administração matinal e noturna. J Bras Ginec 1988; 98(1): 83–6

    Google Scholar 

  15. Catlin BW. Gardnerella vaginalis characteristics, clinical considerations and controversies. Clin Microbiol Rev 1992; 5(3): 213–7

    PubMed  CAS  Google Scholar 

  16. Linhares IM, Bagnoli VR, Halbe HW. Vaginose bacteriana candidose e tricomoniase. In: Halbe, editor. Tratado de Ginecologia, Segunda edição, Vol. 1, Roca, São Paulo, 1993; 876–81

    Google Scholar 

  17. Bartleson NR. Bacterial vaginosis a subtle yet serious infection. Nurse Pract Forum 1992; 3(3): 130–4

    PubMed  CAS  Google Scholar 

  18. Majeroni BA. New concepts in bacterial vaginosis. Am Fam Physician 1991; 44(4): 1215–8

    PubMed  CAS  Google Scholar 

  19. Thomason JL, Gelbert SM, Scaglione NJ. Bacterial vaginosis current review with indications for asymptomatic therapy. Am J Obstet Gynecol 1991; 4(2): 1210–6

    Google Scholar 

  20. Livengood CH, Thomason JL, Hill GB. Bacterial vaginosis diagnostic and pathogenetic findings during topical clindamycin therapy. Am J Obstet Gynecol 1990; 163(2): 515–20

    PubMed  Google Scholar 

  21. Bagnoli VR, Azevedo EMM, Aguiar LM, et al. Vaginites inespecificas: tratamento comparativo entre secnidazol e metronidazol. Folha Médica 1989; 90: 171–4

    Google Scholar 

  22. Hegg R, Ribeiro RM, Bagnoli VR, et al. Treatment of non-specific vaginitis with secnidazole and metronidazole. In: Katz & Willis, editors. Secnidazole: a new approach in 5-nitroimidazole therapy. Symposium Proceedings, Excerpta Medica, Jerusalem, June 11 to 16, 1989; 65–72

  23. Bagnoli VR, Kesselring GL, Fonseca AM, et al. Estudo multicêntrico duplo-cego randomisado comparativo entre secnidazol (2g dose única) e tinidazol (2g dose única) no tratamento ambulatorial de pacientes com vaginite inespecífica. Rev Bras Med 1992; 111(4): 198–202

    Google Scholar 

  24. Hillier S, Krohn MA, Watts DH, et al. Microbiologic efficacy of intravaginal clindamycin cream for the treatment of bacterial vaginosis. Obstet Gynecol 1990; 76(3): 407–13

    PubMed  CAS  Google Scholar 

  25. Cook RL, Redondo Lopes V, Schmitt C, et al. Clinical microbiological and biochemical factors in recurrent bacterial vaginosis. J Clin Microbiol 1992; 30(4): 870–6

    PubMed  CAS  Google Scholar 

  26. Smilack JD, Wilson WWR, Cockerill FR. Tetracyclines chloramphenicol, erythromycin, clindamycin and metronidazole. Mayo Clin Proc 1991; 66(12): 1270–80

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, University of São Paulo, 05403-000, São Paulo, Brazil

    Vicente Renato Bagnoli

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  1. Vicente Renato Bagnoli
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Bagnoli, V.R. An Overview of the Clinical Experience with Secnidazole in Bacterial Vaginosis and Trichomoniasis. Clinical Drug Investigation 8 (Suppl 1), 53–60 (1994). https://doi.org/10.1007/BF03260005

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