Skip to main content
SpringerLink
Log in

Single Dose and Steady-State Pharmacokinetic Profiles of Nifedipine Coat-Core Tablets in Healthy Elderly and Young Volunteers

  • Original Research Article
  • Published:
Drug Investigation Aims and scope Submit manuscript

Summary

21 healthy young and 21 healthy elderly volunteers took part in this nonrandomised, open study to determine and compare the single dose and steady-state pharmacokinetic profiles of nifedipine coat-core (CC) tablets in young and elderly subjects. All volunteers received one nifedipine CC tablet (60mg) once daily for 7 days at 0700h. The single dose and steady-state pharmacokinetic profiles were studied on days 1 and 7, respectively, when serial blood samples were drawn over a 24-hour period for determination of plasma nifedipine concentrations.

After a single dose the extent of absorption of nifedipine appears similar in the young and the elderly, but the rate of absorption appears lower in the elderly compared with the young. The steady-state profiles show a somewhat higher accumulation of the drug in the elderly compared with the young, as well as a lower rate of absorption in the elderly. However, the accumulation of the drug in both the elderly and the young is small in clinical terms, so that a dose reduction for otherwise healthy elderly subjects does not seem to be required.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Crome P, Müller FO, Wijayawardhana P, Groenewoud G, Hundt HKL, et al. The single dose and steady state pharmacokinetic profiles of the nifedipine GITS tablet in healthy elderly and young volunteers. Drug Investigation 5(3): 193–199, 1993

    Article  CAS  Google Scholar 

  • Kleinbloesem CH, van Brummelen P, van der Linde JA, Voogd PJ, Breimer DD. Nifedipine: kinetics and dynamics in healthy subjects. Clinical Pharmacology and Therapeutics 35: 742–749, 1984

    Article  PubMed  CAS  Google Scholar 

  • Murdoch D, Brogden RN. Sustained release nifedipine formulations. Drugs 41: 737–779, 1991

    Article  PubMed  CAS  Google Scholar 

  • Raemsch KD, Sommer J. Pharmacokinetics and metabolism of nifedipine. Hypertension 5 (Suppl. II): 18–24, 1983

    CAS  Google Scholar 

  • Robertson DRC, Waller DG, Renwick AG, George CF. Age-related changes in the pharmacokinetics and pharmacodynamics of nifedipine. British Journal of Clinical Pharmacology 25: 297–305, 1988

    Article  PubMed  CAS  Google Scholar 

  • Scott M, Castleden CM, Adam HK, Smith RP, Fitzsimons TJ. The effect of ageing on the disposition of nifedipine and atenolol. British Journal of Clinical Pharmacology 25: 289–296, 1988

    Article  PubMed  CAS  Google Scholar 

  • Steinijans VW. Pharmacokinetic characterization of controlled-release formulations. European Journal of Drug Metabolism and Pharmacokinetics 15: 173–181, 1990

    Article  PubMed  CAS  Google Scholar 

  • Steinijans VW, Trautmann H, Johnson E, Beier W. Theophylline steady-state pharmacokinetics: recent concepts and their application in chronotherapy of reactive airway diseases. Chronobiology International 4: 331–347, 1987

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. FARMOVS Institute for Clinical Pharmacology and Drug Development, Department of Pharmacology, University of the Orange Free State, Bloemfontein, South Africa

    F. O. Müller, R. Schall, G. Groenewoud, H. K. L. Hundt, H. G. Luus & M. van Dyk

  2. Guy’s Hospital, St Thomas Street, London, England

    J. Henry

Authors
  1. F. O. Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Henry
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Schall
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Groenewoud
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. K. L. Hundt
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. G. Luus
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. van Dyk
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Müller, F.O., Henry, J., Schall, R. et al. Single Dose and Steady-State Pharmacokinetic Profiles of Nifedipine Coat-Core Tablets in Healthy Elderly and Young Volunteers. Drug Invest. 5, 243–249 (1993). https://doi.org/10.1007/BF03259588

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03259588

Keywords

Search

Navigation