Onset Time for High-Dose Vecuronium after Propofol or Thiopental Anaesthesia
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The effect of bolus administration of high-dose vecuronium (0.17 mg/kg) on neuromuscular blockade in terms of onset time, duration of action and recovery rate were studied in 30 patients anaesthetised with either propofol 2 mg/kg or thiopental 5 mg/kg.
Neuromuscular block was registered by measuring mechanical responses of adductor pollicis muscle after supramaximal stimulation of the ulnar nerve at 0.1Hz and 2Hz.
The onset time was significantly shorter in patients anaesthetised with propofol than in those anaesthetised with thiopental (106 vs 156 seconds; p < 0.01). However, there was no significant difference between the 2 groups in either the duration of action of vecuronium neuromuscular blockade or the recovery rate.
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- Feldman S, Fauvel N, Harrop-Griffith W. The onset of neuromuscular blockade. In Bowman et al. (Eds) Neuromuscular blocking agents: past, present, future, pp. 44–51, Excerpta Medica, Amsterdam, 1990Google Scholar
- Kon Park W, Lynch C III. Propofol and thiopental depression of myocardial contractility. A comparative study of mechanical and electrophysiologic effects in isolated guinea pig ventricular muscle. Anesthesia and Analgesia 74: 395–405, 1992Google Scholar
- Lippmann M, Paicius RM, Gingerich S, Owens R, Mok MS, et al. A controlled study of the hemodynamic effects of propofol versus thiopental during anesthesia induction. Seminars in Anesthesia VII: 116–122, 1988Google Scholar
- Stanski DR, Watkins WD. Drug disposition in anesthesia, pp. 106–108, Grune and Stratton, New York, 1982Google Scholar
- Streisand JB, Stanley TH. The respiratory effects of Dipravan (propofol) with and without fentanyl. Seminars in Anesthesia VII(Suppl. 1): 123–126, 1988Google Scholar