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Drug Investigation

, Volume 2, Issue 3, pp 200–202 | Cite as

Zidovudine and Hepatic Oxidative Drug Metabolism

  • Michael G. Barry
  • Fiona Mulcahy
  • John Feely
Short Communication
  • 3 Downloads

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References

  1. Blum MR, Lao SHT, Good SS, de Miranda P. Pharmacokinetics and bioavailability of zidovudine in humans. American Journal of Medicine (Suppl. 2A): 189–194, 1988Google Scholar
  2. Collins JM, Unadkat JD. Clinical pharmacokinetics of zidovudine. Clinical Pharmacokinetics 17: 1–9, 1989PubMedCrossRefGoogle Scholar
  3. Desmond PV, Patwardhan R, Parker R, Schenker S, Speed KV. Effect of cimetidine and other antihistaminics on the elimination of aminopyrine, phenacetin and caffeine. Life Science 26: 1261–1268, 1980CrossRefGoogle Scholar
  4. Fischl MA, Richman DD, Grieco MH, Gottlieb MS, Volberding PA, et al. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS related complex. New England Journal of Medicine 317: 185–191, 1987PubMedCrossRefGoogle Scholar
  5. Good SS, Durack DT, de Miranda P. Biotransformation in various species and in humans of 3′-azido-3′-deoxythymidine, a potential agent for treatment of AIDS. Federation Proceedings 45: 444, 1986Google Scholar
  6. Henry DA, Sharp G, Chaplain S, Cartwright S, Kitchingman G, et al. The 14C-aminopyrine breath test: a comparison of different forms of analysis. British Journal of Clinical Pharmacology 8: 539–545, 1979PubMedCrossRefGoogle Scholar
  7. Henry DA, Macdonald IA, Kitchingman G, Bell GD, Langman MJS. Cimetidine and ranitidine: comparison of effects on hepatic drug metabolism. British Medical Journal 281: 775–777, 1980PubMedCrossRefGoogle Scholar
  8. Hepner GW, Vesell ES, Lipton A, Harvey HA, Wilkinson GR, et al. Disposition of aminopyrine, antipyrine, diazepam and indocyanine green in patients with liver disease or on anticonvulsant drug therapy: diazepam breath test and correlations in drug elimination. Journal of Laboratory and Clinical Medicine 80: 440–456, 1977Google Scholar
  9. Millar A. Aids and the lung. British Medical Journal 249: 1334–1337, 1987CrossRefGoogle Scholar
  10. Richman DD, Fischl MA, Grieco MH, Gottlieb MS, Volberding PA, et al. The toxicity of azidothymidine (AZT) in the treatment of patients with aids and aids related complex. New England Journal of Medicine 317: 192–197, 1987PubMedCrossRefGoogle Scholar

Copyright information

© Adis International Limited 1990

Authors and Affiliations

  • Michael G. Barry
    • 1
  • Fiona Mulcahy
    • 2
  • John Feely
    • 1
  1. 1.Department of Pharmacology and TherapeuticsTrinity CollegeDublinIreland
  2. 2.Department of Clinical MedicineSt James’s HospitalDublinIreland

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