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Chronic Granulomatous Disease

Pathogenesis and Management

  • Practical Therapeutics
  • Published:
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Summary

chronic granulomatous disease is a rare disorder of phagocyte oxidative metabolism. The disease is characterised by recurrent infections in childhood that require prolonged courses of antimicrobial therapy. Adjunctive therapy with interferon-γ has been shown to reduce the frequency and severity of infections. Combined use of daily prophylactic antibiotics and thrice weekly therapy with interferon-γ is an effective and well tolerated treatment that reduces the risk of serious infection. We also update the progress that defines the molecular basis of the disease.

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Authors and Affiliations

  1. Divisions of Hematology/Oncology and Infectious Diseases, Children’s Hospital and Dana-Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts, 02116, USA

    R. Alan B. Ezekowitz & Quentin Eichbaum

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  1. R. Alan B. Ezekowitz
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  2. Quentin Eichbaum
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Ezekowitz, R.A.B., Eichbaum, Q. Chronic Granulomatous Disease. Clin. Immunother. 3, 184–190 (1995). https://doi.org/10.1007/BF03259054

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