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Complete toxicological screening with aniracetam, a nootropic agent, showed the drug to be very well tolerated by mice, rats, rabbits and dogs, after both single and repeated dose administration. No adverse effects on the reproductive system were seen and the compound was negative in a battery of mutagenicity tests. Lifelong treatment in mice and rats did not reveal any carcinogenic potential of the drug. The effects found in the various animal studies occurred only at extremely high doses and were in general of minor toxicological relevance. The therapeutic index of the compound is therefore considered to be very large.
KeywordsDrug Invest High Dose Group Bodyweight Gain Aniracetam Toxicological Profile
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