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S-Adenosyl-L-Methionine Protects against Haemorrhagic Pancreatitis in Partially Immunosuppressed Pancreaticoduodenal Transplant Recipients

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Summary

Pancreaticoduodenal transplantation from normal (strain PVG.RT1c) to diabetic (strain PVG.RT1u) rats evoked a biphasic attack on pancreatic acinar tissue. The first phase was accompanied by pancreatic oedema. The second phase coincided with heavy leucocytic infiltration of exocrine tissue and was followed by haemorrhagic pancreatitis. Most rats died when still normoglycaemic, at 8 to 10 days. Treatment with cyclosporin A in standard immunosuppressive doses controlled diabetes but failed to prevent lethal pancreatitis. Treatment with S-adenosyl-L-methionine (SAMe) in combination with cyclosporin A assured long term survival with normal pancreatic function. The possible mechanisms by which SAMe exhibits a protective function are discussed in the following paper.

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Authors and Affiliations

  1. University Department of Surgery, The Royal Infirmary, Manchester, England

    P. D. Scott

  2. Immunology Group, Department of Cell & Structural Biology, University of Manchester Medical School, Manchester, M13 9PT, England

    M. Knoop &  I. V. Hutchinson

  3. Department of Pathological Sciences, University of Manchester Medical School, Manchester, England

    R. F. T. McMahon

  4. University Department of Gastroenterology, The Royal Infirmary, Manchester, England

    J. M. Braganza

Authors
  1. P. D. Scott
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  2. M. Knoop
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  3. R. F. T. McMahon
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  4. J. M. Braganza
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  5. I. V. Hutchinson
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Scott, P.D., Knoop, M., McMahon, R.F.T. et al. S-Adenosyl-L-Methionine Protects against Haemorrhagic Pancreatitis in Partially Immunosuppressed Pancreaticoduodenal Transplant Recipients. Drug Invest 4 (Suppl 4), 69–77 (1992). https://doi.org/10.1007/BF03258366

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  • DOI: https://doi.org/10.1007/BF03258366

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