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Active Expectant Management Prolongs Latency in Multiple Gestations Complicated by Preterm Premature Rupture of Fetal Membranes (PROM)

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Summary

Previous experience has shown that an ‘active expectant management’ protocol consisting of prophylactic antibacterial agents, tocolysis and intensive fetal monitoring is superior to passive expectant management in patients with premature rupture of fetal membranes (PROM). In this study, active expectant management utilising ceftizoxime or ampicillin was compared with passive expectant management in 18 patients with multiple gestation (17 twins and 1 triplet). The mean latent phase of the active group was 10.95 days vs 0.4 days in the passive group (p = 0.0015). Ceftizoxime appeared to be superior to ampicillin with respect to certain areas of management, but there was no difference in infectious morbidity between groups.

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References

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Miami Valley Hospital, Regional Perinatal Health Center, Wright State University School of Medicine, 1 Wyoming Street, CHE Bldg, Suite 3800, Dayton, Ohio, 45409, USA

    S. J. Fortunato & E. C. Bryant

  2. East Tennessee State University, James H. Quillen College of Medicine, Johnson City, Tennessee, USA

    S. I. Welt & M. K. Eggleston

Authors
  1. S. J. Fortunato
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  2. S. I. Welt
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  3. E. C. Bryant
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  4. M. K. Eggleston
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Fortunato, S.J., Welt, S.I., Bryant, E.C. et al. Active Expectant Management Prolongs Latency in Multiple Gestations Complicated by Preterm Premature Rupture of Fetal Membranes (PROM). Drug Invest 4 (Suppl 1), 21–25 (1992). https://doi.org/10.1007/BF03258340

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  • DOI: https://doi.org/10.1007/BF03258340

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