Summary
Roxithromycin is one of the newer macrolide antibiotics, and displays a superior gastrointestinal absorption, higher plasma concentrations and a longer plasma half-life than its analogue, erythromycin, thereby permitting once- or twice-daily administration. Its tissue distribution is extensive because of its high lipid solubility, and penetration into the respiratory tract tissues is adequate and comparable to that seen with erythromycin. Roxithromycin’s intracellular penetration is superior to that of erythromycin, conferring bactericidal efficacy against intracellular pathogens such as Chlamydia and Legionella pneumophila. Roxithromycin displays nonlinear phar-macokinetics, with no appreciable accumulation and a low propensity for drug interactions.
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Nilsen, O.G. Roxithromycin. Drug Invest 3 (Suppl 3), 28–32 (1991). https://doi.org/10.1007/BF03258332
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DOI: https://doi.org/10.1007/BF03258332