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Nebivolol Improves the Vessel Wall Properties of the Common Carotid Artery

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Summary

The effect of nebivolol on compliance of the common carotid artery was studied noninvasively in hypertensive patients. Nebivolol decreased blood pressure and heart rate. Vessel wall properties (distensibility and compliance) of the common carotid artery increased significantly during nebivolol treatment, while the diameter remained unchanged. This favourable influence of nebivolol on the vessel wall properties of the common carotid artery (and possibly on other large arteries) might protect these vessels from atherosclerosis. The effect of other β-adrenoceptor antagonists on large arteries is discussed.

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Authors and Affiliations

  1. Departments of Pharmacology, Physiology, Biophysics and Medicine, University of Limburg, PO Box 616, 6200 MD, Maastricht, The Netherlands

    L. M. A. B. Van Bortel, T. Van Merode, F. A. M. Smeets, R. S. Reneman, J. M. V. Mooij & H. A. J. Struyker Boudier

Authors
  1. L. M. A. B. Van Bortel
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  2. T. Van Merode
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  3. F. A. M. Smeets
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  4. R. S. Reneman
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  5. J. M. V. Mooij
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  6. H. A. J. Struyker Boudier
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Additional information

Full details of this study have been previously published in Journal of Pharmacology and Experimental Therapeutics 251: 599–605, 1989. This article is published with permission.

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Van Bortel, L.M.A.B., Van Merode, T., Smeets, F.A.M. et al. Nebivolol Improves the Vessel Wall Properties of the Common Carotid Artery. Drug Invest 3 (Suppl 1), 61–63 (1991). https://doi.org/10.1007/BF03258265

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  • DOI: https://doi.org/10.1007/BF03258265

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