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Phenobarbital Enhances Sister Chromatid Exchanges In Vivo

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Summary

In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%.

This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.

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Authors and Affiliations

  1. State University, Genova, Italy

    Carlo Bellini &  Eugenio Bonioli (Chair of Pediatric Therapy)

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  1. Carlo Bellini
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  2. Eugenio Bonioli
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Bellini, C., Bonioli, E. Phenobarbital Enhances Sister Chromatid Exchanges In Vivo . Drug Invest 2, 138–141 (1990). https://doi.org/10.1007/BF03258255

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  • DOI: https://doi.org/10.1007/BF03258255

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