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Intensive Multiple Drug Induction Chemotherapy for Small-Cell Lung Cancer

A Pilot Study

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Summary

The use of multiple drug regimens has been successfully applied as an intensive chemotherapy in malignant lymphoma.

We tested a combination of 7 cytostatic agents in small cell lung cancer: intravenous cyclophosphamide (500 mg/m2 day 1), doxorubicin (adriamycin) [25 mg/m2 day 1], etoposide (120 mg/m2 day 1), cisplatin (60 mg/m2 day 8), vindesine (3 mg/m2 day 8), vincristine (2mg total dose day 15) and methotrexate (100 mg/m2 day 15).

25 patients were registered and 21 were évaluable for responses: 8 with limited disease and 13 with disseminated disease. In patients with limited disease, 2 complete and 1 partial response were obtained; in those with disseminated disease, there were 3 complete and 9 partial responses. One toxic death was observed. Haematological tolerance was acceptable but a significant polyneuropathy was observed in 8 patients.

The concept of a multiple drug regimen is now being tested by the European Organization for Research on Treatment of Cancer (EORTC) Lung Cancer Working Party in a phase III randomised study.

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Authors and Affiliations

  1. Service de Médecine Interne et Laboratoire d’Investigation Clinique, H. J. Tagnon, Institut Jules Bordet, Centre des Tumeurs de l’Université Libre de Bruxelles, Brussels, Belgium

    Jean-Paul Sculier, Jean Klastersky & Paule Mommen

  2. Service de Médecine Interne, Hôpital de Waterloo/Braine-l’Alleud, Belgium

    Claude Finet

  3. Service d’Hématologie et d’Oncologie, Centre Hospitalier de Luxembourg, Grand-Duché de Luxembourg

    Fernand Ries

  4. Hôpital Saint-Pierre, Brussels, Belgium

    Roger Sergysels

Authors
  1. Jean-Paul Sculier
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  2. Jean Klastersky
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  3. Claude Finet
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  4. Fernand Ries
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  5. Roger Sergysels
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  6. Paule Mommen
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Sculier, JP., Klastersky, J., Finet, C. et al. Intensive Multiple Drug Induction Chemotherapy for Small-Cell Lung Cancer. Drug Invest 2, 99–104 (1990). https://doi.org/10.1007/BF03258247

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  • DOI: https://doi.org/10.1007/BF03258247

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