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Clinical Experience in Disorders of Haemostasis

  • Section 2: Desmopressin in Haemostatic Disorders
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Summary

Desmopressin has found clinical application in a variety of haemostatic disorders affecting platelet function or factor VIII activity. These disorders include haemophilia A, von Willebrand’s disease (vWD), uraemia, congenital platelet dysfunction, and the haemostatic derangement caused by cardiopulmonary bypass. Desmopressin may also be useful in acquired disorders of platelet function such as those caused by antiplatelet drugs, and in hepatic cirrhosis.

These disorders of haemostasis may produce excessive bleeding during minor or major surgical procedures, with accidental trauma, or spontaneously. The traditional approach has emphasised blood component therapy when excessive bleeding is apparent or likely to occur. However, transfusion therapy is not without risk. Pharmacological agents such as desmopressin that are not derived from blood products offer the potential to achieve adequate haemostasis without the risks of transfusion therapy.

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  1. Division of Cardiology and Department of Cardiothoracic Surgery, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, California, USA

    Lawrence S. C. Czer

  2. Divisions of Hematology and Transfusion Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA

    Stephen M. Capon

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Czer, L.S.C., Capon, S.M. Clinical Experience in Disorders of Haemostasis. Drug Invest 2 (Suppl 5), 32–44 (1990). https://doi.org/10.1007/BF03258241

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