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Piroxicam-β-Cyclodextrin in the Treatment of Dysmenorrhoea

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Summary

Piroxicam-β-cyclodextrin has been shown to be significantly more effective than placebo in the relief of menstrual pain and the somatic symptoms associated with dysmenorrhoea. In comparative studies with naproxen and ketoprofen, piroxicam-β-cyclodextrin was shown to produce an earlier onset of pain relief with a longer lasting effect. Tolerability with piroxicam-β-cyclodextrin was good, with few side effects being reported. The efficacy and tolerability of piroxicam-β-cyclodextrin make it well qualified for use as first-line therapy for primary dysmenorrhoea in patients in whom oral contraception is not required or who are unable to tolerate estrogenic and progestational agents.

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Authors and Affiliations

  1. Second Obstetrics and Gynecology Department, University of Bologna, Bologna, Italy

    S. Costa

  2. Obstetrics and Gynecology Department, S. Maria Nuova Hospital Reggio Emilia, Bologna, Italy

    G. Zinelli

  3. Medical Department, Chiesi Farmaceutici, Parma, Italy

    L. Bufalino

Authors
  1. S. Costa
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  2. G. Zinelli
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  3. L. Bufalino
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Costa, S., Zinelli, G. & Bufalino, L. Piroxicam-β-Cyclodextrin in the Treatment of Dysmenorrhoea. Drug Invest 2 (Suppl 4), 73–78 (1990). https://doi.org/10.1007/BF03258231

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  • DOI: https://doi.org/10.1007/BF03258231

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