PEG-SO3H as a new, highly efficient and homogeneous polymeric catalyst for the synthesis of bis(indolyl)methanes and 4,4′-(arylmethylene)-bis(3-methyl-1-phenyl-1Hpyrazol-5-ol)s in water

Abstract

In this work, a green, simple and highly efficient procedure for the synthesis of bis(indolyl)methanes and 4,4′- (arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s [as an important class of bis(pyrazolyl)methanes] is described. The condensation of indoles or 1-phenyl-3-methylpyrazol-5-one with carbonyl compounds catalyzed by poly(ethylene glycol)-bound sulfonic acid (PEG-SO3H) in water affords the title compounds in high yields and relatively short reaction times.

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Hasaninejad, A., Shekouhy, M., Zare, A. et al. PEG-SO3H as a new, highly efficient and homogeneous polymeric catalyst for the synthesis of bis(indolyl)methanes and 4,4′-(arylmethylene)-bis(3-methyl-1-phenyl-1Hpyrazol-5-ol)s in water. JICS 8, 411–423 (2011). https://doi.org/10.1007/BF03249075

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Keywords

  • Poly(ethylene glycol)-bound sulfonic acid (PEG-SO3H)
  • Bis(indolyl)methane
  • Bis(pyrazolyl)methane
  • 4,4′-(Arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)
  • Polymeric catalyst