Abstract
Several new pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-e][1,4]diazepine, pyrazolo[3,4-d][1,2,3]triazine and pyrolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives were prepared by the reaction of the corresponding 5-amino-pyrazole-4-carbonitrile derivative with different organic reagents under different reaction conditions. Using IR, 1H NMR, and mass spectra we have characterized all new compounds.
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M.H. Elnagdi, N. Al-Awadi, A.W. Erian, in: A.R. Katrizky, C.W. Rees, E.F.V. Scriven, (Eds.), “Comprehensive Heterocyclic Chem. II” Pergamon Press, Oxford, 1996, p. 431.
S.M. Desenko, S.A. Komykhov, V.D. Orlov, H. Meier, J. Heterocyclic Chem. 35 (1998) 989.
J. Quiroga, B. Insuasty, S. Craz., P. Hermandez, A. Bolafios, R. Moreno, A. Hormoa, R. H. de Almeidas, Heterocyclic Chem. 35 (1998) 1333.
G.A. Youngdle, U.S. Patent, 4 288 440 (1980); C.A. 96 (1982) 6596c.
A.H. Todd, Br. Patent, 1203 149 (1970); C.A. 73 (1970) 120 508b.
J. Gante and S. Lust, Ger. Offen. 1 908 947 (1970); C.A. 73 (1970) 120501.
J. L. Huppatz., Aust. J. Chem. 36 (1983) 135.
J.E. Francis, W.D. Cash, S. Psychoyos, G. Ghai, P. Wenk, R.C. Friedmann, C. Atkins, V. Warren, P. Furness, J.L. Hyun, G.A. Stone, M. Desai, M. Williams, J. Med. Chem. 31 (1988) 1014.
J.E. Francis, W.D. Cash, B.S. Barbaz, P.S. Bernard, R. A. Lovell, G.C. Mazzenga, R.C. Friedmann, J.L. Hyun, A.F. Braunwalder, P.S. Loo, D.A. Bennett, J. Med. Chem. 34 (1991) 281.
R. Fusco, R. Trave, Rend. Ist. Lombardo Sci. Pt. 1, 91, 202 (1957); C.A. 52 (1958) 1186h.
C.S. Lu, E. W. Hughes, P.A. Giguere, J. Am. Chem. Soc. 63 (1941) 1507.
R. Balicki, Ł Kaczmarek, Synth. Commun. 23 (1993) 3149.
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Harb, A.F.A., Abbas, H.H. & Mostafa, F.H. Pyrazoles as building blocks in heterocyclic synthesis: Synthesis of pyrazolo [3,4-d]pyrimidine, pyrazolo[3,4-e][1,4]diazepine, pyrazolo [3,4-d][1,2,3]triazine and pyrolo [4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives. JICS 2, 115–123 (2005). https://doi.org/10.1007/BF03247202
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DOI: https://doi.org/10.1007/BF03247202