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AZT binding to DNA and RNA: Molecular modeling and biological significance

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Abstract

In this review we report the application of molecular modeling based on different analytical methods to locate the binding sites of anti-AIDS drug azidothymidine (AZT) in the major and minor grooves of DNA and RNA duplexes. The effects of drug complexation on nucleic acids secondary structures and the biological implication are discussed.

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Abbreviations

AZT:

3′-azido-3′-deoxythymidine

8-oxo-dG:

8-oxo-2′-deoxyguanosine

HIV-1:

human immunodeficiency virus-1

CE:

capillary electrophoresis

FTIR:

Fourier transform infrared

A:

adenine

C:

cytosine

G:

guanine

T:

thymine

U:

uracil

r:

drug/polynucleotide (P) molar ratio

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Authors and Affiliations

  1. Department of Chemistry-Biology, University of Québec at Trois-Rivières, C.P. 500, Québec, Canada, G9A 5H7

    H. A. Tajmir-Riahi

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  1. H. A. Tajmir-Riahi
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Correspondence to H. A. Tajmir-Riahi.

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Tajmir-Riahi, H.A. AZT binding to DNA and RNA: Molecular modeling and biological significance. JICS 2, 78–84 (2005). https://doi.org/10.1007/BF03247200

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