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A new and more practical approach to the synthesis of the precursor of SC-84536, a selective inducible nitric oxide synthase inhibitor

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Abstract

SC-84536, a selective inhibitor of inducible nitric oxide synthase (INOS), is targeted for the treatment of osteoarthritis, neuropathic pain and asthma. This report describes our effort toward developing an alternative synthetic route for preparation of SC-84536. In the process, we also developed a new and simple method for the preparation of phthalimide 6, a potentially useful synthon.

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Authors and Affiliations

  1. Pfizer, PGRD, Groton, Ct 06340, USA

    P. G. M. Wuts

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  1. P. G. M. Wuts
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Correspondence to P. G. M. Wuts.

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Wuts, P.G.M. A new and more practical approach to the synthesis of the precursor of SC-84536, a selective inducible nitric oxide synthase inhibitor. JICS 5, 306–308 (2008). https://doi.org/10.1007/BF03246122

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  • DOI: https://doi.org/10.1007/BF03246122

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