Skip to main content
SpringerLink
Log in

Rapid and accurate amperometric determination of acetaminophen in pharmaceutical preparations and spiked human blood serum samples at cadmium pentacyanonitrosylferrate modified glassy carbon electrode

  • Article
  • Published:
Journal of the Iranian Chemical Society Aims and scope Submit manuscript

Abstract

The present work describes a rapid and accurate amperometric technique for the determination of acetaminophen (ACT) in pharmaceutical preparations and human blood serum, based on electrocatalytic oxidation of ACT at a glassy carbon electrode modified by cadmium pentacyanonitrosylferrate (CdPCNF) film. The electrocatalytic response of the modified GC electrode was linear over the concentration of 1.64-52.90 μM. The limit of detection was found to be 2.04 μM by amperometric technique. The method was successfully utilized for the determination of ACT in various pharmaceutical preparations and the results have been statistically compared with those obtained by the official method. The interference of some pharmaceutical and biological compounds was investigated. The results of interference study showed that the Nafion-coated CdPCNF|GC electrode can be utilized as a selective amperometric sensor for acetaminophen determination in human blood serum. The mean value of rate constant k for catalytic reaction, and the diffusion coefficient of ACT (D) in the phosphate buffer solution of pH 7.2 were found to be 4.27 × 102 M−1 s−1, and (4.25 ± 0.33) × 10−6 cm2 s−1, respectively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. Wade (Ed.), Martindale the Extra Pharmacopoeia, 27th ed., The Pharmaceutical Press, London, 1979.

  2. J. Koch-Weser, New Engl. J. Med. 295 (1976) 1297.

    CAS  Google Scholar 

  3. S.P. Clissold, Drugs 32 (1986) 46.

    Google Scholar 

  4. C.J. Nikles, M. Yelland, C.D. Marc, D. Wilkinson, Am. J. Therap. 12 (2005) 80.

    Google Scholar 

  5. M.K. Srivastava, S. Ahmad, D. Singh, I.C. Shukla, Analyst 110 (1985) 735.

    CAS  Google Scholar 

  6. K.G. Kumar, R. Letha, J. Pharm. Biomed. Anal. 15 (1997) 1725.

    CAS  Google Scholar 

  7. S. Dunkerley, M.J. Adams, Lab. Autom. Inf. Manage. 33 (1997) 107.

    CAS  Google Scholar 

  8. P. Nagaraja, K.C. Srinivasa Murthy, K.S. Rangappa, J. Pharm. Biomed. Anal. 17 (1998) 501.

    CAS  Google Scholar 

  9. V. Rodenas, M.S García, C. Sánchez-Pedreño, M.I. Albero, Talanta 52 (2000) 517.

    CAS  Google Scholar 

  10. N. Erk, Y. Özkan, E. Banoolu, S.A. Özkan, Z. Aentürk, J. Pharm. Biomed. Anal. 24 (2001) 469.

    CAS  Google Scholar 

  11. J.L. Vilchez, R. Blanc, R. Avidad, A. Navalón, J. Pharm. Biomed. Anal. 13 (1995) 1119.

    CAS  Google Scholar 

  12. A. Eustaquio, M. Blanco, R.D. Jee, A.C. Moffat, Anal. Chim. Acta 383 (1999) 283.

    CAS  Google Scholar 

  13. J. Wang, T. Golden, P. Tuzhi, Anal. Chem. 59 (1987) 740.

    CAS  Google Scholar 

  14. W. Peng, T. Li, H. Li, E. Wang, Anal. Chim. Acta 298 (1994) 415.

    CAS  Google Scholar 

  15. M.E. Sadek, A.E. Shanawany, A.A. Khier, G. Rücker, Analyst 115 (1990) 1181.

    Google Scholar 

  16. G. Indrayanto, A. Sunarto, Y. Adriani, J. Pharm. Biomed. Anal. 13 (1995) 1555.

    CAS  Google Scholar 

  17. A.M.D. Pietra, R. Gatti, V. Andrisano, V. Cavrini, J. Chromatogr. A 729 (1996) 355.

    Google Scholar 

  18. J.L. Pérez, M.A. Bello, Talanta 48 (1999) 1199.

    Google Scholar 

  19. D.J. Speed, S.J. Dickson, E.R. Cairns, N.D. Kim, J. Anal. Toxicol. 25 (2001) 198.

    CAS  Google Scholar 

  20. M.J. Ayora Cañada, M.I. Pascual Reguera, A. Ruiz Medina, M.L. Fernández de Córdova, A. Molina Díaz, J. Pharm. Biomed. Anal. 22 (2000) 59.

    Google Scholar 

  21. Z. Bouhsain, S. Garrigues, A. Morales-Rubio, M. de la Guardia, Anal. Chim. Acta 330 (1996) 59.

    CAS  Google Scholar 

  22. A. Criado, S. Cárdenas, M. Gallego, M. Valcárcel, Talanta 53 (2000) 417.

    CAS  Google Scholar 

  23. J.A. Murillo Pulgarín, L.F. García Bermejo, Anal. Chim. Acta 333 (1996) 59.

    Google Scholar 

  24. A. Ruiz Medina, M.L. Fernandez de Córdova, A. Molina-Diaz, J. Pharm. Biomed. Anal. 21 (1999) 983.

    CAS  Google Scholar 

  25. M.L. Ramos, J.F. Tyson, D.J. Curran, Anal. Chim. Acta 364 (1998) 107.

    CAS  Google Scholar 

  26. A. Townshend, Analyst 115 (1990) 495.

    CAS  Google Scholar 

  27. K. Robards, P.J. Worsfold, Anal. Chim. Acta 266 (1992) 147.

    CAS  Google Scholar 

  28. B.J. Hindson, N.W. Barnett, Anal. Chim. Acta 445 (2001) 1.

    CAS  Google Scholar 

  29. I.I. Koukli, A.C. Calokerinos, T.P. Hadjiioannou, Analyst 114 (1989) 711.

    CAS  Google Scholar 

  30. A. Gregorio Alapont, L. Lahuerta Zamora, J. Martínez Calatayud, J. Pharm. Biomed. Anal. 21 (1999) 311.

    CAS  Google Scholar 

  31. D. Easwaramoorthy, Y.C. Yu, H.J. Huang, Anal. Chim. Acta 439 (2001) 95.

    CAS  Google Scholar 

  32. H. Razmi, A. Azadbakht, Electrochim. Acta 50 (2005) 2193.

    CAS  Google Scholar 

  33. H. Razmi, A. Azadbakht, Anal. Sci. 21 (2005) 1317.

    CAS  Google Scholar 

  34. A.J. Bard, L.R. Faulkner, Electrochemical Methods, Fundamentals and Applications, John Wiley /s Sons, New York, 1980, p. 218.

    Google Scholar 

  35. A.J. Bard, L.R. Faulkner, Electrochemical Methods, Fundamentals and Applications, John Wiley & Sons, New York, 1980, p. 222.

    Google Scholar 

  36. A.J. Bard, L.R. Faulkner, Electrochemical Methods, Fundamentals and Applications, John Wiley & Sons, New York, 1980, p. 143.

    Google Scholar 

  37. Z. Galus, Fundamentals of Electrochemical Analysis, Ellis Horwood, New York, 1976.

  38. British Pharmacopoeia, Vol. 1, 1998.

Download references

Author information

Authors and Affiliations

  1. Electrochemistry Research Lab., Faculty of Science, Azarbaijan University of Tarbiat Moallem, P.O. Box: 53714-161, Tabriz, Iran

    H. Razmi & M. Harasi

Authors
  1. H. Razmi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Harasi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to H. Razmi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Razmi, H., Harasi, M. Rapid and accurate amperometric determination of acetaminophen in pharmaceutical preparations and spiked human blood serum samples at cadmium pentacyanonitrosylferrate modified glassy carbon electrode. JICS 5, 296–305 (2008). https://doi.org/10.1007/BF03246121

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03246121

Keywords

Search

Navigation