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A highly efficient protocol for the synthesis of N-aryl nucleobases using zinc oxide in ionic liquids

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Abstract

A highly efficient and simple method for the synthesis of N-aryl derivatives of pyrimidine and purine nucleobases via Narylation of nucleobases using zinc oxide in 1-butyl-3-methylimidazolium bromide ([bmim]Br) under microwave as well as thermal conditions is described. In both conditions, the title compounds were produced in high to excellent yields and in short reaction times.

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Authors and Affiliations

  1. Department of Chemistry, Payame Noor University (PNU), Iran

    A. Zare, A. R. Moosavi-Zare, F. Khedri, F. Asadi, N. Hayati & A. Asifi

  2. Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr, 75169, Iran

    A. Hasaninejad

  3. Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454, Iran

    A. Khalafi-Nezhad & M. H. Beyzavi

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  1. A. Zare
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Correspondence to A. Zare or A. Hasaninejad.

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Zare, A., Hasaninejad, A., Khalafi-Nezhad, A. et al. A highly efficient protocol for the synthesis of N-aryl nucleobases using zinc oxide in ionic liquids. JICS 7, 461–469 (2010). https://doi.org/10.1007/BF03246033

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  • DOI: https://doi.org/10.1007/BF03246033

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