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Ca(HSO4)2 mediated conversion of alcohols into N-substituted amides under heterogeneous conditions: A modified Ritter reaction

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Abstract

Tertiary, secondary, and benzylic alcohols react efficiently with nitriles in the presence of the catalyst calcium hydrogen sulfate, Ca(HSO4)2, to produce amides in high yields. In this study, a modified Ritter reaction using this solid acid catalyst is found to be an environmentally safe method for converting 2,6-bis(hydroxymethyl)-4-halo anisole into the corresponding diamides in CH3CN.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Sciences, Persian Gulf University, Bushehr, 75169, Iran

    K. Niknam & T. Sadabadi

  2. Faculty of Chemistry, Bu-Ali Sina University, Hamadan, 65174, Iran

    M. A. Zolfigol

Authors
  1. K. Niknam
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  2. M. A. Zolfigol
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  3. T. Sadabadi
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Correspondence to K. Niknam.

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Niknam, K., Zolfigol, M.A. & Sadabadi, T. Ca(HSO4)2 mediated conversion of alcohols into N-substituted amides under heterogeneous conditions: A modified Ritter reaction. JICS 4, 199–204 (2007). https://doi.org/10.1007/BF03245967

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  • DOI: https://doi.org/10.1007/BF03245967

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