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One-pot synthesis of pyrano[2,3-d]pyrimidinone derivatives catalyzed by L-proline in aqueous media

Journal of the Iranian Chemical Society volume 6, pages 436–442 (2009)Cite this article

Abstract

An efficient protocol has been developed for the synthesis of various pyrano[2,3-d]pyrimidinones from condensation of aromatic aldehydes, malononitrile and barbituric-or thiobarbituric acid in aqueous ethanol using L-proline as a neutral bifunctional catalyst.

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Authors and Affiliations

  1. Peptide Chemistry Research Group, K. N. Toosi University of Technology, P.O. Box, 15875-4416, Tehran, Iran

    M. Bararjanian, S. Balalaie, B. Movassag & A. M. Amani

Authors
  1. M. Bararjanian
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  2. S. Balalaie
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  3. B. Movassag
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  4. A. M. Amani
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Corresponding author

Correspondence to S. Balalaie.

Additional information

Dedicated to Prof. Abbas Shafiee on the occasion of his 70th birthday

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Bararjanian, M., Balalaie, S., Movassag, B. et al. One-pot synthesis of pyrano[2,3-d]pyrimidinone derivatives catalyzed by L-proline in aqueous media. JICS 6, 436–442 (2009). https://doi.org/10.1007/BF03245854

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  • DOI: https://doi.org/10.1007/BF03245854

Keywords

  • Aqueous media
  • L-Proline
  • Pyrano[2,3-d]pyrimidinone
  • Domino Knoevenagel-cyclocondensation