Potential health benefits of spirulina microalgae*

A review of the existing literature

Summary

The purpose of this paper is to first describe the species Arthrospira platensis, previously referenced as ‘Spirulina platensis’ (commonly referred to as ‘Spirulina’), and then to provide a review of the literature in regards to four main areas of Spirulina research: Immune system modulation; anti-viral activity; cancer preventive properties, and cardiovascular benefits. This paper focuses on research done since the year 2000, but references some important work completed before 2000 in certain cases. All citations are from published journals.

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References

  1. 1

    United Nations World Food Conference (1974) As reported on the Intergovernmental Institution for the Use of Microalgae Spirulina Against Malnutrition (Permanent Observer to the United Nations Economic and Social Council) www.iimsam.org

    Google Scholar 

  2. 2

    United Nations Food and Agriculture Organisation (FAO) Report (2008) As reported on the Intergovernmental Institution for the Use of Microalgae Spirulina Against Malnutrition (Permanent Observer to the United Nations Economic and Social Council) www.iimsam.org

    Google Scholar 

  3. 3

    Henrikson R (1989) Earth Food Spirulina Ronore Enterprises, Inc ISBN #0-9623111-0-3

    Google Scholar 

  4. 4

    Moorhead K, Capelli B, Cysewski G (2005) Nature’s Superfood: Spirulina ISBN #0-9637511-3-1

    Google Scholar 

  5. 5

    Gemma C, Mesches MH, Sepesi B, Choo K, Holmes DB, Bickford PC (2002) Diets enriched in foods with high antioxidant activity reverse ageinduced decreases in cerebellar b-andrenergic function and increases in pro-inflammatory cytokines J Neurosci 22(14) 6114–6120

    CAS  Google Scholar 

  6. 6

    Stromberg I, Gemma C, Vila J, Bickford PC (2005) Blueberry and Spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system J Exp Neurol 196(2) 298–307

    Google Scholar 

  7. 7

    Wang Y, Chang CF, Chou J, Chen HL, Deng X et al (2005) Dietary supplementation with blueberries, spinach or Spirulina reduces ischemic brain damage. J Exp Neurol 193(1) 75–84

    CAS  Google Scholar 

  8. 8

    Blinkova LP, Gorobets OB, Baturo AP (2001) Biological activity of Spirulina Mikrobial Epidemiol Immunobiol 2 114–118

    Google Scholar 

  9. 9

    Hirahashi T, Matsumoto M, Hazeki K, Saeki Y, Ui M, Seya T (2002) Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis Int Immunopharmacol 2(4) 423–434

    CAS  Google Scholar 

  10. 10

    Pugh N, Ross SA, ElSohly HN, ElSohly MA, Pasco DS (2001) Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosa Planta Medica 67(8) 737–742

    CAS  Google Scholar 

  11. 11

    Grzanna R, Polotsky A, Phan PV, Pugh N, Pasco D, Frondoza CG (2006) Immolina, a high-molecular-weight polysaccharide fraction of Spirulina, enhances chemokine expression in human monocytic THP-1 cells J Alternate Compliment Med 12(5) 429–435

    Google Scholar 

  12. 12

    Balachandran P, Pugh ND, Ma G, Pasco DS (2006) Toll-like receptor 2-dependent activation of monocytes by Spirulina polysaccharide and its immune enhancing action in mice Int Immunopharmacol 6(12) 1808–1814

    CAS  Google Scholar 

  13. 13

    Lobner M, Walsted A, Larsen R, Bendtzen K, Nielsen CH (2008) Enhancement of human adaptive immune responses by administration of a high-molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis J Med Food 11(2) 313–322

    Google Scholar 

  14. 14

    Nemoto-Kawamura C, Hirahashi T, Nagai T et al (2004) Phycocyanin enhances secretary IgA antibody response and suppresses IgE antibody response in mice immunized with antigenentrapped biodegradable microparticles J Nutr Sci Vitamin 50(2) 129–136

    Google Scholar 

  15. 15

    Mao TK, Van de Water J, and Gershwin ME (2005) Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients J Med Food 8(1) 27–30

    CAS  Google Scholar 

  16. 16

    Mao TK, Van de Water J, Gershwin ME (2000) Effect of Spirulina on the secretion of cytokines from peripheral blood mononuclear cells J Med Food 3(3) 135–140

    CAS  Google Scholar 

  17. 17

    Hayashi T, Hayashi K, Maeda M, Kojima I (1996) Calcium Spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis J Nat Prod 59(1) 83–87

    CAS  Google Scholar 

  18. 18

    Hayashi K, Hayashi T, Kojima I (1996) A natural sulfated polysaccharide, Calcium Spirulan, isolated from Spirulina platensis: In vitro and ex vivo evaluation of anti-herpes simplex virus and anti-human immunodeficiency virus activities Aids Res Human Retroviruses 12(15) 1463–1471

    CAS  Google Scholar 

  19. 19

    Teas J, Hebert JR, Fitton JH, Zimba PV (2004) Algae — a poor man’s HAART? Med Hypothesis 64(4) 507–510

    Google Scholar 

  20. 20

    Ayehunie S, Belay A, Baba TW, Ruprecht RM (1998) Inhibition of HIV-1 replication by an aqueous extract of Spirulina platensis (Arthrospira platensis) J Acq Immune Def Syndromes Human Retrovirol 18(1) 7–12

    CAS  Google Scholar 

  21. 21

    Hernandez-Corona A, Nieves I, Meckes M et al (2002) Antiviral activity of Spirulina maxima against herpes simplex virus type 2 Antiviral Res 56(3) 279–285

    CAS  Google Scholar 

  22. 22

    Gorobets OB, Blinkova LP, Baturo AP (2002) Action of Spirulina platensis on bacterial viruses Mikrobial Epidemiol Immunobiol (6) 18–21

    Google Scholar 

  23. 23

    Schwartz J, and Shklar G (1987) Regression of experimental hamster cancer by beta carotene and algae extracts J Oral Maxillofacial Surg 45(6) 510–515

    CAS  Google Scholar 

  24. 24

    Schwartz J, Shklar G, Reid S, Trickler D (1988) Prevention of experimental oral cancer by extracts of Spirulina-Dunaliella algae Nutr Cancer 11(2) 127–134

    CAS  Google Scholar 

  25. 25

    Mathew B, Sankaranarayanan R, Nair PP, Varghese C, Somanathan T, Amma BP, Amma NS, Nair MK (1995) Evaluation of chemoprevention of oral cancer with Spirulina fusiformis Nutr Cancer 24(2) 197–202

    CAS  Google Scholar 

  26. 26

    Mishima T, Marata J, Toyoshima M, Fujii H et al (1998) Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis Clin Exp Metas 16(6) 541–550

    CAS  Google Scholar 

  27. 27

    Zhang HQ, Lin AP, Sun Y, Deng YM (2001) Chemo- and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs Acta Pharmacol Sinica 22(12) 1121–1124

    CAS  Google Scholar 

  28. 28

    Liu XM, and Zhang HQ (2002) Effect of polysaccharide from Spirulina platensis on hematopoietic cells proliferation, apoptosis and Bcl-2 expression in mice bearing tumor treated with chemotherapy Acta Pharmacol Sinica 37(8) 616–620

    CAS  Google Scholar 

  29. 29

    Grawish ME (2008) Effects of Spirulina platensis extract on Syrian hamster cheek pouch mucosa painted with 7,12-dimethylbenz(a)anthracene Oral Oncol 44(10) 956–962

    Google Scholar 

  30. 30

    Grawish ME, Zaber AR, Gaafar AI, Nasif WA (2010) Long-term effect of Spirulina platensis extract on DMBA-induced hamster buccal pouch carcinogenesis (immunohistochemical study) Med Oncol 27(1) 20–28

    Google Scholar 

  31. 31

    Akao Y, Ebihara T, Masuda H, Saeki Y, Akazawa T et al (2009) Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice Cancer Sci 100(8) 1494–1501

    CAS  Google Scholar 

  32. 32

    Subbashini J, Mahipal SV, Reddy MC, Mallikarjuna Reddy M, Rachamallu A, Reddanna P (2004) Molecular mechanisms in C-Phycocyanin induced apoptosis in human chronic myeloid leukemia cell line K-562 Biochem Pharmacol 68(3) 453–462

    Google Scholar 

  33. 33

    Roy KR, Arunasree KM, Reddy NP, Dheeraj B et al (2007) Alteration of mitochondrial membrane potential by Spirulina platensis C-phycocyanin induces apoptosis in the doxorubicinresistant human hepatocellular-carcinoma cell line HepG2 Biotechnol Appl Biochem 47(Pt 3) 159–167

    CAS  Google Scholar 

  34. 34

    Li B, Gao MH, Zhang XC, Chu XM (2006) Molecular immune mechanism of C-phycocyanin from Spirulina platensis induces apoptosis in HeLa cells in vitro Biotechnol Appl Biochem 43(Pt 3) 155–164

    CAS  Google Scholar 

  35. 35

    Li B, Zhang X, Gao M, Chu X (2005) Effects of CD59 on antitumoral activities of phycocyanin from Spirulina platensis Biochem Pharmacol 59(10) 551–560

    CAS  Google Scholar 

  36. 36

    Chen T, Wong YS (2008) In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis J Agricul Food Chem 56(12) 4352–4358

    CAS  Google Scholar 

  37. 37

    Chen F, and Zhang Q (1995) Inhibitive effects of Spirulina on aberrant crypts in colon induced by dimethylhydrazine Chinese J Prevent Med 29(1) 13–17

    CAS  Google Scholar 

  38. 38

    Dasgupta T, Banejee S, Yadav PK, Rao AR (2001) Chemomodulation of carcinogen metabolizing enzymes, antioxidant profiles and skin and forestomach papillomagenesis by Spirulina platensis Mol Cell Biochem 226(1–2) 27–38

    CAS  Google Scholar 

  39. 39

    Chamorro-Cevalls G, Garduno-Siciliano L et al (2008) Chemoprotective effect of Spirulina (Arthrospira) against cyclophosphamide-induced mutagenicity in rats Food Chem Toxicol 46(2) 567–574

    Google Scholar 

  40. 40

    Juarez-Oropeza MA, Mascher D, Torres-Duran PV et al (2009) Effects of Spirulina on vascular reactivity J Med Food 12(1) 15–20

    CAS  Google Scholar 

  41. 41

    Torres-Duran PV, Ferreira-Hermosillo A et al (2007) Antihyperlipidemic and antihypertensive effects of Spirulina maxima in an open sample of Mexican population: a preliminary report Lipids Health Dis 26 6–33

    Google Scholar 

  42. 42

    Park HJ, Lee YJ, Ryu HK, Kim MH et al (2008) A randomized double-blind, placebo-controlled study to establish the effects of Spirulina in elderly Koreans Annals Nutr Metab 52(4) 322–328

    CAS  Google Scholar 

  43. 43

    Samuels R, Mani UV, Iyer UM, Nayak US (2002) Hypocholesterolemic effect of Spirulina in patients with hyperlipidemic nephrotic syndrome J Med Food 5(2) 91–96.

    CAS  Google Scholar 

  44. 44

    Nagaoka S, Shimizu K, Kaneko H, Shibayama F et al (2005) A novel protein C-phycocyanin plays a crucial role in the hypocholesterolemic action of Spirulina platensis concentrate in rats J Nutr 135(10) 2425–2430

    CAS  Google Scholar 

  45. 45

    Khan M, Shobha JC, Mohan IK, Naidu MU et al (2005) Protective effect of Spirulina against doxorubicin-induced cardiotoxicity Phytother Res 19(12) 1030–1037

    CAS  Google Scholar 

  46. 46

    Khan M, Varadharaj S, Shobba JC, Naidu MU et al (2006) C-Phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult rat cardiomyocytes J Cardiovasc Pharmacol 47(1) 9–20.

    CAS  Google Scholar 

  47. 47

    Khan M, Varadharaj S, Ganesan LP et al (2005) C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling Am J Physiol-Heart Circulatory Physiol 290(5) H2136–2145

    Google Scholar 

  48. 48

    Han LK, Li DX, Xiang L, Gong XJ, Kondo Y, Suzuki I, Okuda H (2006) Isolation of pancreatic lipase activity-inhibitory component of Spirulina platensis and it reduces postprandial triacyglycerolemia Yakugaku Zasshi J Pharmaceut Soc Japan 126(1) 43–49

    CAS  Google Scholar 

  49. 49

    Kaji T, Fujiwara Y, Hamada C, Yamamoto C et al (2002) Inhibition of cultured bovine aortic endothelial cell proliferation by sodium spirulan, a new sulfated polysaccharide isolated from Spirulina platensis Planta Medica 68(6) 505–509

    CAS  Google Scholar 

  50. 50

    Kaji T, Okabe M, Shimada S, Yamamoto C et al (2004) Sodium Spirulan as a potent inhibitor of arterial smooth muscle cell proliferation in vitro Life Sci 74(19) 2431–2439

    CAS  Google Scholar 

  51. 51

    Riss J, Decorde K, Sutra T, Delage M et al (2007) Phycobiliprotein C-phycocyanin from Spirulina platensis is powerfully responsible for reducing oxidative stress and NADPH oxidase expression induced by an atherogenic diet in hamsters J Agricul Food Chem 55(19) 7962–7967

    CAS  Google Scholar 

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An extensive compilation of published research on the potential health benefits of Spirulina is available from the authors. Please contact us at info@cyanotech.com

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Capelli, B., Cysewski, G.R. Potential health benefits of spirulina microalgae*. Nutrafoods 9, 19–26 (2010). https://doi.org/10.1007/BF03223332

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Key words

  • Spirulina
  • Arthrospira platensis
  • Immune system
  • Cardiovascular system
  • Anti-viral action
  • Cancer prevention