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Targeted polymeric gene delivery for anti-angiogenic tumor therapy

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Abstract

Gene therapy has become a promising strategy for the treatment of genetically based diseases, such as cancer, which are currently considered incurable. A major obstacle in the field of cancer gene therapy is the development of a safe and efficient delivery system for therapeutic gene transfer. Non-viral vectors have attracted great interest, as they are simple to prepare, stable, easy to modify and relatively safe compared to viral vectors. In this review, an insight into the strategies developed for polyethylenimine (PEI)-based non-viral vectors has been provide, including improvement of the polyplex properties by incorporating hydrophilic spacer, poly(ethylene glycol) (PEG).Moreover, this review will summarize the strategies for the tumor targeting. Specifically, a targeted polymeric gene delivery system, PEI-g-PEG-RGD, will be introduced as an efficient gene delivery vector for tumor therapy, including its functional analysis bothin vitro andin vivo.

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  1. Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 20 S 2030 E RM 205 BPRB, 84112-5820, Salt Lake City, UT, USA

    Won Jong Kim & Sung Wan Kim

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  1. Won Jong Kim
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Kim, W.J., Kim, S.W. Targeted polymeric gene delivery for anti-angiogenic tumor therapy. Macromol. Res. 15, 100–108 (2007). https://doi.org/10.1007/BF03218760

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