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Swelling behavior and mechanical strength of crosslinked dextran hydrogel

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Abstract

Dextran as a candidate material for colon-specific drug delivery has been studied. Crosslinked dextran hydrogels were prepared by mixing dextran, MgCl2, glutaraldehyde (GA) and polyethyleneglycol (PEG 400)|in water. The dextran hydrogels were characterized by measuring equilibrium swelling ratios and mechanical strengths. Response surface methodology (Central Composite Design) was used to evaluate the swelling behaviors and mechanical strengths as functions of concentrations of MgCl2, GA, and PEG 400, which was found to be useful for the evaluation. It showed that the swelling behavior and mechanical strengths were influenced significantly by PEG 400 and MgCl2 concentrations.

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Authors and Affiliations

  1. Faculty of Applied Chemical Engineering, Chonnam National University, 500-757, Gwangju, Korea

    Byung-Hoon Kim, Doman Kim, Yong-Sik Jung, Hoon Kim & Dong Lyun Cho

  2. Engineering Research Institute, Chonnam National University, 500-757, Gwangju, Korea

    Byung-Hoon Kim, Doman Kim, Yong-Sik Jung, Hoon Kim & Dong Lyun Cho

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  1. Byung-Hoon Kim
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  2. Doman Kim
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  3. Yong-Sik Jung
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  4. Hoon Kim
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  5. Dong Lyun Cho
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Kim, BH., Kim, D., Jung, YS. et al. Swelling behavior and mechanical strength of crosslinked dextran hydrogel. Macromol. Res. 11, 291–295 (2003). https://doi.org/10.1007/BF03218366

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  • DOI: https://doi.org/10.1007/BF03218366

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