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Phase behaviors of binary protein systems: Consideration of structural effects

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Abstract

A molecular-thermodynamic model to describe the salt-induced protein precipitation is developed based on the perturbation theory. We employed the modified perturbed hard-sphere-chain (PHSC) equation of state for copolymer mixtures to take into account the pre-aggregation effect among protein particles. Hypothetical pressurecomposition diagrams are computed with various size differences and salt concentrations. The precipitation behaviors are also studied for various types of pre-aggregation effect for the given systems.

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Authors and Affiliations

  1. Division of Chemical Engineering, Hanyang University, 133-791, Seoul, Korea

    Sang Gon Kim, Sung Ho Kong & Young Chan Bae

  2. Department of Environmental Geosystem Engineering, Hanyang University, 133-791, Seoul, Korea

    Sunjoon Kim

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  1. Sang Gon Kim
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  2. Sung Ho Kong
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  3. Young Chan Bae
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  4. Sunjoon Kim
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Kim, S.G., Kong, S.H., Bae, Y.C. et al. Phase behaviors of binary protein systems: Consideration of structural effects. Macromol. Res. 11, 241–249 (2003). https://doi.org/10.1007/BF03218359

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  • DOI: https://doi.org/10.1007/BF03218359

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