Skip to main content
SpringerLink
Log in

Video-assisted thoracoscopic lobectomy reduces cytokine production more than conventional open lobectomy

  • Original Article
  • Published:
The Japanese Journal of Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

Abstract

Objective: We studied cytokine changes after video-assisted thoracoscopic lobectomy and conventional lobectomy in patients with stage IA lung cancer. Methods: From June, 1997, 20 consecutive patients with stage IA non small-cell lung carcinoma underwent either conventional lobectomy via an open thoracotomy (n = 10) or video-assisted thoracoscopic lobectomy (n = 10). The cytokine concentration in serum and pleural fluid were measured for 6 days postoperatively. Results: Interleukin-6 and interleukin-8 leads peaked at 3 h or 1 day after surgery. Cytokine levels in pleural fluid were more than 100 times higher than corresponding systemic levels. The increase of interleukin-6 in pleural fluid 3 hours after surgery was significantly smaller in video-assisted thoracoscopic lobectomy (3971 ± 2793 pg/mL for video-assisted thoracoscopic lobectomy vs. 23274 ± 8426 pg/mL for open lobectomy). There were no significant differences in the serum interleukin-6 and interleukin-8 concentrations between the 2 groups. Conclusion: The thoracoscopic approach lessened the increase of cytokines in pleural fluid, but benefits of reduced cytokine production in video-assisted thoracoscopy remain to be clarified.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kirby TJ, Mack MJ, Landreneau RJ, Rice TW. Initial experience with video-assisted thoracoscopic lobectomy. Ann Thorac Surg 1993; 56: 1248–52.

    Article  PubMed  CAS  Google Scholar 

  2. Giudicelli R, Thomas P, Lonjon T, Ragni J, Bulgare JC, Ottomani R, et al. Major pulmonary resection by video assisted mini-thoracotomy. Eur J Cardio-thorac Surg 1994; 8: 254–8.

    Article  CAS  Google Scholar 

  3. Solaini L, Baginoni P, Grandi U. Role of videoendo-scopy in pulmonary surgery: Present experience. Eur J Cardio-Thorac Surg 1995; 9: 65–8.

    Article  CAS  Google Scholar 

  4. McKenna RJ. Thoracoscopic lobectomy with mediastinal sampling in 80-year-old patients. Chest 1994; 106: 1902–4.

    Article  PubMed  Google Scholar 

  5. Roviaro G, Varoli F, Rebuffat C, Scalambra SM, Vergani C, Sibilla E, et al. Videothoacoscopic staging and treatment of lung cancer. Ann Thorac Surg 1995; 56: 971–4.

    Article  Google Scholar 

  6. Kirby TJ, Mack MJ, Landreneau RJ, Rice TW. Lobectomy-video-assisted thoracic surgery versus muscle-sparing thoracotomy. A randomized trial. J Thorac Cardiovasc Surg 1995; 109: 997–1002.

    Article  PubMed  CAS  Google Scholar 

  7. Asamura H, Nakayama H, Kondo H, Tsuchiya R, Naruke T. Video-assisted lobectomy in the elderly. Chest 1997; 111: 1101–5.

    Article  PubMed  CAS  Google Scholar 

  8. Martini N. Mediastinal lymph node dissection for lung cancer. The memorial experience. Chest Surg Clin N Am 1995; 5: 189–203.

    PubMed  CAS  Google Scholar 

  9. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definition for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20: 864–74.

    Article  Google Scholar 

  10. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM., Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 1992; 101: 1644–55.

    Article  PubMed  CAS  Google Scholar 

  11. Antony VB, Godbey SW, Kunkel SL, Hott JW, Hartman DL, Burdick MD, et al. Recruitment of inflammatory cells to the pleural space. Chemotactic cytokines, IL-8, and monocyte chemotactic peptide-1 in human pleural fluids. J Immunol 1993; 151: 7216–23.

    PubMed  CAS  Google Scholar 

  12. Sakamoto K, Arakawa H, Mita S, Ishiko T, Ikei S, Egami H, et al. Elevation of circulating interleukin 6 after surgery: Factors influencing the serum level. Cytokine 1994; 6: 181–6.

    Article  PubMed  CAS  Google Scholar 

  13. Butler J, Chong GL, Baigrie RJ, Pillai R, Westaby S, Rocker GM. Cytokine response to cardiopulmonary bypass with membrane and bubble oxygenation. Ann Thorac Surg 1992; 53: 833–8.

    Article  PubMed  CAS  Google Scholar 

  14. Cremer J, Martin M, Redl H, Bahrami S, Abraham C, Graeter T, et al. Systemic inflammatory response syndrome after cardiac operations. Ann Thorac Surg. 1996; 61: 1714–20.

    Article  PubMed  CAS  Google Scholar 

  15. Tovey MG, Content J, Gresser I, Gugenheim J, Blanchard B, Guymarho J, Poupart P, Gigou M, Shaw A, Fiers W. Genes for IFN-β-2 (IL-6), tumor necrosis factor, and IL-1 are expressed at high levels in the organs of normal individuals. J Immunol 1988; 141: 3106–10.

    PubMed  CAS  Google Scholar 

  16. Shenkin A, Fraser WD, Series J, Winstanley FP, McCartney AC, Burns HJ, et al. The serum interleukin 6 response to elective surgery. Lymphokine Res 1989; 8: 123–7.

    PubMed  CAS  Google Scholar 

  17. Cruickshank AM, Fraser WD, Burns HJG, Van Damme J, Shenkin A. Response of serum interleukin-6 in patients undergoing elective surgery of varying severity. Clin Sci 1990; 79: 161–5.

    PubMed  CAS  Google Scholar 

  18. Walker WS, Craig SR. Video-assisted thoracoscopic pulmonary surgery — current status and potential evolution. Eur J Cardiothorac Surg 1996; 10: 161–7.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Research, National Sanyo Hospital, 685 Higashikiwa, Ube, 755-0241, Yamaguchi, Japan

    Kazuro Sugi, Yoshikazu Kaneda & Kensuke Esato

  2. First Department of Surgery, Yamaguchi University School of Medicine, Ube, Japan

    Yoshikazu Kaneda & Kensuke Esato

Authors
  1. Kazuro Sugi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yoshikazu Kaneda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kensuke Esato
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sugi, K., Kaneda, Y. & Esato, K. Video-assisted thoracoscopic lobectomy reduces cytokine production more than conventional open lobectomy. Jpn J Thorac Caridovasc Surg 48, 161–165 (2000). https://doi.org/10.1007/BF03218114

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03218114

Key words

Search

Navigation