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Video-assisted thoracoscopic lobectomy reduces cytokine production more than conventional open lobectomy

The Japanese Journal of Thoracic and Cardiovascular Surgery volume 48, pages 161–165 (2000)Cite this article

Abstract

Objective: We studied cytokine changes after video-assisted thoracoscopic lobectomy and conventional lobectomy in patients with stage IA lung cancer. Methods: From June, 1997, 20 consecutive patients with stage IA non small-cell lung carcinoma underwent either conventional lobectomy via an open thoracotomy (n = 10) or video-assisted thoracoscopic lobectomy (n = 10). The cytokine concentration in serum and pleural fluid were measured for 6 days postoperatively. Results: Interleukin-6 and interleukin-8 leads peaked at 3 h or 1 day after surgery. Cytokine levels in pleural fluid were more than 100 times higher than corresponding systemic levels. The increase of interleukin-6 in pleural fluid 3 hours after surgery was significantly smaller in video-assisted thoracoscopic lobectomy (3971 ± 2793 pg/mL for video-assisted thoracoscopic lobectomy vs. 23274 ± 8426 pg/mL for open lobectomy). There were no significant differences in the serum interleukin-6 and interleukin-8 concentrations between the 2 groups. Conclusion: The thoracoscopic approach lessened the increase of cytokines in pleural fluid, but benefits of reduced cytokine production in video-assisted thoracoscopy remain to be clarified.

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Affiliations

  1. Department of Clinical Research, National Sanyo Hospital, 685 Higashikiwa, Ube, 755-0241, Yamaguchi, Japan

    Kazuro Sugi, Yoshikazu Kaneda & Kensuke Esato

  2. First Department of Surgery, Yamaguchi University School of Medicine, Ube, Japan

    Yoshikazu Kaneda & Kensuke Esato

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  1. Kazuro Sugi
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  2. Yoshikazu Kaneda
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  3. Kensuke Esato
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Sugi, K., Kaneda, Y. & Esato, K. Video-assisted thoracoscopic lobectomy reduces cytokine production more than conventional open lobectomy. Jpn J Thorac Caridovasc Surg 48, 161–165 (2000). https://doi.org/10.1007/BF03218114

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  • DOI: https://doi.org/10.1007/BF03218114

Key words

  • VATS lobectomy
  • cytokine
  • interleukin-6
  • interleukin-8
  • human