Abstract
Three TNFα-inhibitory lignans were isolated from the flower buds ofMagnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-α production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity (IC50=51 µM).
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References Cited
Beutler, P. B.,Tumor necrosis factors: The molecules and their emerging role in medicine. Raven press, New York, pp. 561–574, 1992.
Briggs, L. H., Cambie, R. C. and Couch, R. A. F., Lirioresinol-C dimethylether, a diaxially substituted 3,7-dioxabicyclo [3,3,0] octane lignan fromMacropiper excelsum (Forst, f.) Miq. J. Chem. Soc, (C), 3042–3045 (1968).
MacRae, W. D. and Tower, G. H. N., Biological activities of lignans.Phytochemistry, 23 (6), 1207–1220 (1984).
Miyazawa, M., Kasahara, H. and Kameoka, H., Phenolic lignans from flower buds of Magnolia fargesii.Phytochemistry, 31 (10), 3666–3668 (1992).
Pari, J-X., Hensens, O. D., Zink, D. L., Chang, M. N. and Hwang, S. B., Lignans with platelet activating factor antagonist activity fromMagnolia biondii.Phytochemistry, 26 (5), 1377–1379 (1987).
Pelter, A. and Ward, R. S., Revised structure for epiaschantin and epimagnolin.Tetrahedron Lett., 47, 4137–4140 (1977).
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Chae, SH., Kim, PS., Cho, JY. et al. Isolation and identification of inhibitory compounds on TNF-α production fromMagnolia fargesii . Arch. Pharm. Res. 21, 67–69 (1998). https://doi.org/10.1007/BF03216755
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DOI: https://doi.org/10.1007/BF03216755