Abstract
The well established and known chemistry of metal phosphides as nucleophilic and reactive precursors has been used as a suitable synthetic approach in the synthesis of 1,2-bis(butylphenylphosphino) ethane (bppe) (5) andcis-1,2-bis(butylphenylphosphino) ethylene (bppey) (6). Adducts of bridged and bis-chelated gold(I) with 5 and 6, as well as silver(I) with 5, have been prepared in moderate to good yields. These complexes have been characterised by solution NMR spectroscopy, mass spectrometry (FAB) and microanalysis in case of 10a, 10b and 11.
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Mr. David Khanye David Khanye is currently a first year PhD student at the University of Cape Town working on gold complexation of thiosemicarbazones and isothiazoles under supervision of Prof. Kelly Chibale, Dr. Judy Caddy and Dr. Greg Smith.
Dr. Marcus Layh Dr. Marcus Layh is currently a research associate at the University of Münster and has held previous industrial and academic positions in Germany, the UK and South Africa. His research interests are in the field of main group organometallic chemistry.
Dr. Judy Caddy Judy joined Mintek in 2003 after obtaining her PhD in Organic Chemistry at the University of Johannesburg (Rand Afrikaans University). She began her research career looking at the synthesis and biological activity of a variety of phosphine compounds in a secondment to University of Witwatersrand. During this time Judy undertook a research visit to Heidelberg, Germany, where she investigated the gold labelling of neurologically active pentapeptides. Shortly after her return to South Africa she began heading up the AuTEK Biomedical Programme, along with taking on an honorary position at the University of Witwatersrand. Over the past three years Judy has actively supervised and co-supervised student projects at collaborating universities, along with her research activities at Mintek, where she is now involved in the development of therapies for cancer, HIV and malaria.
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Khanye, D.S., Caddy, J. & Layh, M. Gold(I) Complexes of 1,2-bis(butylphenyl phosphino)ethane andcis-1,2-bis(butyl phenylphosphino) ethylene. Gold Bull 40, 45–51 (2007). https://doi.org/10.1007/BF03215292
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DOI: https://doi.org/10.1007/BF03215292