Gold Bulletin

, Volume 29, Issue 3, pp 87–93 | Cite as

Gold drugs: Mechanism of action and toxicity

  • Sabine L Best
  • Peter J Sadler
Open Access


Gold drugs are still amongst the most efficacious for the treatment of rheumatoid arthritis. Their mechanism of action, as well as the molecular basis of their side-effects, remain poorly understood. Current theories are reviewed, including recent potential breakthroughs. The interaction of gold(III) with peptides and proteins and its immunochemical implications are discussed.


Major Histocompatibility Complex Major Histocompatibility Complex Class Auranofin Aurothiomalate Tetrachloroaurate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© World Gold Council 1996

Authors and Affiliations

  • Sabine L Best
    • 1
  • Peter J Sadler
    • 1
  1. 1.Department of Chemistry, Birkbeck CollegeUniversity of London, Gordon House and Christopher Ingold LaboratoriesLondonUK

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