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Negative association of Epstein-Barr virus or herpes simplex virus-1 with tumefactive central nervous system inflammatory demyelinating disease

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Abstract

Central nervous system (CNS) demyelination has been suggested to be associated with infections caused by the Epstein-Barr virus (EBV) or herpes simplex virus (HSV)-1. CNS inflammatory demyelinating disease (IDD) rarely presents as a large lesion. We evaluated samples of serum and cerebrospinal fluid (CSF) by enzyme-linked immunosorbent assay to detect recent infection with these viruses and analyzed CSF and brain specimens by polymerase chain reaction (PCR) or immunohistochemical studies for evidence of these viruses in three patients with biopsy-proven CNS IDD. The results of PCR tests for EBV and HSV in CSF or brain specimens were negative. Elevated anti-EBV or -HSV antibody levels were not found in serum or CSF in any patient. Immunohistochemical studies showed that IDD lesions were negative for latent membrane protein (LMP)-1, Epstein-Barr nuclear antigen (EBNA)-2, and EBNA noncoding RNA (EBER)-1. These results suggest a negative association between CNS IDD and EBV or HSV.

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Authors and Affiliations

  1. Department of Neurology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan

    Takao Kiriyama, Hiroshi Kataoka & Satoshi Ueno

  2. Department of Diagnostic Pathology, Nara Medical University, Kashihara, Nara, Japan

    Takahiko Kasai & Akitaka Nonomura

Authors
  1. Takao Kiriyama
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  2. Hiroshi Kataoka
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  3. Takahiko Kasai
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  4. Akitaka Nonomura
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  5. Satoshi Ueno
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Corresponding author

Correspondence to Hiroshi Kataoka.

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This paper was first published online on Early Online on 11 November 2010.

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Kiriyama, T., Kataoka, H., Kasai, T. et al. Negative association of Epstein-Barr virus or herpes simplex virus-1 with tumefactive central nervous system inflammatory demyelinating disease. Journal of NeuroVirology 16, 466–471 (2010). https://doi.org/10.1007/BF03210852

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  • DOI: https://doi.org/10.1007/BF03210852

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