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Calculation of steady-state distribution delay between central and peripheral compartments in two-compartment models with infusion regimen

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Summary

A lag time may exist between blood drug concentration and drug effect. Various factors can contribute to the lag time, among which the drug distribution delay is a significant one. The drug distribution delay can also exist between different compartments. An equation was derived to calculate the steady-state drug concentration delay between central and peripheral compartments in a two-compartment model with infusion regimen.

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Authors and Affiliations

  1. Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, Université de la Méditerranée Aix-Marseille II, Marseille, France

    Guang Wu MD, PhD

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  1. Guang Wu MD, PhD
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Wu, G. Calculation of steady-state distribution delay between central and peripheral compartments in two-compartment models with infusion regimen. Eur. J. Drug Metab. Pharmacokinet. 27, 259–264 (2002). https://doi.org/10.1007/BF03192336

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  • DOI: https://doi.org/10.1007/BF03192336

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